Leishmaniosis is a tropical neglected parasitic disease that is endemic in many countries, including Middle East, with no existing effective vaccines. The bite of female sand-fly transmits the causative agent, Leishmania spp., to humans. High toxicity, resistance and treatment failure of the available chemotherapy against visceral leishmaniosis demands the investigation of new anti-leishmanial compounds. Lupeol is a form of triterpene isolated from several medicinal plants and possesses an antimicrobial property. In this study, cytotoxic effect of lupeol was screened against the mammalian amastigotes form and insect promastigote form of Leishmania donovani, following three cycles of incubation at different concentrations by MTT assay. Results revealed the in vitro anti-leishmanial effect of lupeol on both forms of the parasite where significant decline in promastigotes and amastigotes growth was observed. This was conducted along three times of follow up (24, 48, 72) hours, in comparison to the classical sodium stibogluconate treatment. Cell viability was calculated and the minimum IC50 was detected after 48 hours for amastigotes and 24 hours for promastigotes, 12.125 µM, 102.78 µM, respectively. Given the severity of visceral leishmaniosis and the toxicity of conventional chemotherapies, the anti-leishmanial activity of lupeol suggested a promising compound for additional clinical trials
Background: Iraq is among counttries of intermediate hepatitis B endemicity. Although several studies have been carried out on the prevalence of HBV markers.
The railways network is one of the huge infrastructure projects. Therefore, dealing with these projects such as analyzing and developing should be done using appropriate tools, i.e. GIS tools. Because, traditional methods will consume resources, time, money and the results maybe not accurate. In this research, the train stations in all of Iraq’s provinces were studied and analyzed using network analysis, which is one of the most powerful techniques within GIS. A free trial copy of ArcGIS®10.2 software was used in this research in order to achieve the aim of this study. The analysis of current train stations has been done depending on the road network, because people used roads to reach those train stations. The data layers for this st
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The Early Cenomanian Ahmadi carbonates succession in selected oil-wells in south Iraqi oil fields have undergone; into sequence stratigraphic analysis as new reservoir stratigraphy optimization understanding. The sequence stratigraphy context: has applied on the mentioned carbonate reservoir in selected oil-wells from West-Qurna and Majnoon oil fields, with respect to Arabian-plate (AP) chronosequence stratigraphy and chrono-markers setting.
A meso-genetic buildup has infra-structured the studied Formation based-on; smallest-set of the genetically-related high-frequency lithofacies-cycle and cycles-set modeling. A genetic sequence (meso-sequence one MS1) is described as a well-encountered buildup between the (MFS-K120 of lower Ah
... Show MoreBackground: The problem of excessive alcohol consumption is a major cause of public health concern in most countries of the world today. Royal Colleges of Physicians and Psychiatrists recommended that every inpatient should be screened with a questionnaire for alcohol related problems. Therefore, this work was carried out to report on alcoholism in the emergency unit in two general hospitals in Baghdad, Iraq.
Methods: The study was carried out in Al-Sader general hospital (Al-Sader city, Baghdad) and Baghdad teaching hospital (Baghdad) for the period 1st July 2008 to 1st May 2009. Data collection was two days per week. Version of 25 items Michigan Alcoholism Screening Test (MAST) and semi-structured
Iraq faces significant economic challenges, owing in part to its reliance on oil revenue and the country's overburdened public sector. The supremacy of State-Owned Enterprises (SOEs), obstructive rules, a lack of access to finance, a shortage of skilled labor, and inadequate infrastructure all impede private sector growth. This research relied mainly on information from global development organizations, most markedly the World Bank, as well as policy documents, and it discovered a scarcity of pertinent educational writings. The following are the key findings of this research: Recent economic growth has not resulted in poverty reduction; the stretched history of war and insecurity in Iraq has hampered progress and development; the private se
... Show MoreAbstract: The M(II) complexes [M2(phen)2(L)(H2O)2Cl2] in (2:1:2 (M:L:phen) molar ratio, (where M(II) =Mn(II), Co(II), Cu(II), Ni(II) and Hg(II), phen = 1,10-phenanthroline; L = 2,2'-(1Z,1'Z)-(biphenyl-4,4'-diylbis(azan-1-yl-1-ylidene))bis(methan-1-yl-1- ylidene)diphenol] were synthesized. The mixed complexes have been prepared and characterized using 1H and13C NMR, UV/Visible, FTIR spectra methods and elemental microanalysis, as well as magnetic susceptibility and conductivity measurements. The metal complexes were tested in vitro against three types of pathogenic bacteria microorganisms: Staphylococcus aurous, Escherichia coli, Bacillussubtilis and Pseudomonasaeroginosa to assess their antimicrobial properties. From this study shows that a
... Show MoreThe reaction of LAs-Cl8 : [ (2,2- (1-(3,4-bis(carboxylicdichloromethoxy)-5-oxo-2,5dihydrofuran-2-yl)ethane – 1,2-diyl)bis(2,2-dichloroacetic acid)]with sodium azide in ethanol with drops of distilled water has been investigated . The new product L-AZ :(3Z ,5Z,8Z)-2azido-8-[azido(3Z,5Z)-2-azido-2,6-bis(azidocarbonyl)-8,9-dihydro-2H-1,7-dioxa-3,4,5triazonine-9-yl]methyl]-9-[(1-azido-1-hydroxy)methyl]-2H-1,7-dioxa-3,4,5-triazonine – 2,6 – dicarbonylazide was isolated and characterized by elemental analysis (C.H.N) , 1H-NMR , Mass spectrum and Fourier transform infrared spectrophotometer (FT-IR) . The reaction of the L-AZ withM+n: [ ( VO(II) , Cr(III) ,Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) and
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Synthesis of sedimentologic, paleocurrent, and organic geochemistry data of the Lower Permian Ga’ara Formation from the Western Desert, western Iraq, shows good hydrocarbon potentiality and deposition by high sinuosity and mixed-load channels, likely by a meandering river system. The Ga’ara Formation includes kaolinitic mudstone beds of various colors and channelized quartzitic sandstone beds. Based on the lithofacies identification, five lithofacies associations have been recognized: channel-floor, point-bar, abandoned channel plug, crevasse splay, and interchannel flood basin. In addition, the paleocurrent analysis and sandstone percentage map indicate a variation of the paleoflow spatially and temporally with a general di
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This paper investigated an Iraqi dataset from Korek Telecom Company as Call Detail Recorded (CDRs) for six months falling between Sep. 2020-Feb. 2021. This data covers 18 governorates, and it falls within the period of COVID-19. The Gravity algorithm was applied into two levels of abstraction in deriving the results as the macroscopic and mesoscopic levels respectively. The goal of this study was to reveal the strength and weakness of people migration in-between the Iraqi cities. Thus, it has been clear that the relationship between each city with the others is based on and of mobile people. However, the COVID-19 effects on the people’s migration needed to be explored. Whereas the main function of the gravity model is to
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The reaction of LAs-Cl8 : [ (2,2- (1-(3,4-bis(carboxylicdichloromethoxy)-5-oxo-2,5- dihydrofuran-2-yl)ethane – 1,2-diyl)bis(2,2-dichloroacetic acid)]with sodium azide in ethanol with drops of distilled water has been investigated . The new product L-AZ :(3Z ,5Z,8Z)-2- azido-8-[azido(3Z,5Z)-2-azido-2,6-bis(azidocarbonyl)-8,9-dihydro-2H-1,7-dioxa-3,4,5- triazonine-9-yl]methyl]-9-[(1-azido-1-hydroxy)methyl]-2H-1,7-dioxa-3,4,5-triazonine – 2,6 – dicarbonylazide was isolated and characterized by elemental analysis (C.H.N) , 1H-NMR , Mass spectrum and Fourier transform infrared spectrophotometer (FT-IR) . The reaction of the L-AZ withM+n: [ ( VO(II) , Cr(III) ,Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) and Hg(II)] has been i
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