Comprehension of the zinc chloride's ameliorative apoptotic and genotoxic effects on mice with cadmium-induced hepatotoxicity

Enas Nihad Bayram; Hanady S. Al-Shmgani Al-Shmgani; Nahla A. Al-Bakri

doi:10.31893/jabb.22035

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Publication Date

Sat Jan 01 2022

Journal Name

Journal Of Animal Behaviour And Biometeorology

Volume

10

DOI

10.31893/jabb.22035

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Comprehension of the zinc chloride's ameliorative apoptotic and genotoxic effects on mice with cadmium-induced hepatotoxicity

cadmium toxicity

comet assay

oxidative liver markers

zinc protection

Enas Nihad Bayram

Hanady S. Al-Shmgani Al-Shmgani

Nahla A. Al-Bakri

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Publication Date

Tue May 20 2025

Journal Name

Vrsacin Deae-cellulose Linezolid Neutrophils Inflammation

Antibacterial and therapeutic effects of vancomycin-resistant Staphylococcus aureus bacteriocin (VRSAcin) in the treatment of VRSA skin infection in mice

VRSAcin DEAE-Cellulose Linezolid Neutrophils Inflammation

AHMED

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Vancomycin Staphylococcus aureus (VRSA) is a strain of S. aureus that is considered the main cause of bacterial skin and soft tissue infections. It has acquired resistance to vancomycin and represents a therapeutic challenge. The current study aimed to compare the possible therapeutic effects of VRSA bacteriocin (VRSAcin) on the treatment of skin infection in mice with those of an antibiotic (linezolid). The results showed that of the fifty swabs obtained from human skin wounds. One isolate was selected for VRSAcin extraction depending on its antibiotic resistance using an antibiotic susceptibility test.An agar well diffusion test was used to determine bacteriocin’s antibacterial activity, as well as its a minimum inhibitory concentration

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Publication Date

Fri Aug 01 2025

Journal Name

Microbial Pathogenesis

Antibacterial and therapeutic effects of vancomycin-resistant Staphylococcus aureus bacteriocin (VRSAcin) in the treatment of VRSA skin infection in mice

Vancomycin Staphylococcus aureus (VRSA) is a strain of S. aureus that is considered the main cause of bacterial skin and soft tissue infections. It has acquired resistance to vancomycin and represents a therapeutic challenge. The current study aimed to compare the possible therapeutic effects of VRSA bacteriocin (VRSAcin) on the treatment of skin infection in mice with those of an antibiotic (linezolid). The results showed that of the fifty swabs obtained from human skin wounds. One isolate was selected for VRSAcin extraction depending on its antibiotic resistance using an antibiotic susceptibility test.An agar well diffusion test was used to determine bacteriocin’s antibacterial activity

as well as its a minimum inhibitory concentration

minimum bactericidal concentration

and antibiofilm efficiency against gram-positive and gram-negative bacteria that were resistant to many medicines. The freshly developed antibacterial substance VRSAcin shows promise. Bacteriocin from VRSA was extracted and studied the optimal conditions for the Production following Purification of bacteriocin by ammonium sulfate precipitation followed by cation-exchange chromatography. The molecular weight of bacteriocin about (29 kDa) were determined by Sodium Dodecyl Sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The typical conditions for the production of VRSAcin include a pH of 7 and a temperature of 37 ◦C for 48 h. In mice

VRSA-contaminated wounds revealed severe tissue distraction and inflammation that extended to the hypodermis

while VRSA-treated skin showed mild changes and localized lesions to the epidermis and upper dermis. The skin of linezolid ointment-treated mice showed moderate to severe changes. In conclusion

VRSA strain infections in human burned skin were more common than expected. In vivo studies in mice indicated that wounded skin infected with VRSA can be treated with VRSAcin as an antibacterial agent that promotes healing processes with obvious superiority to linezolid ointment. As a result

the VRSA develops bacteriocins that are appropriate for regulating AMR

Gram-positive and Gram-negative bacteria

and may be useful in wound dressings.

Ahmed Qassim

Mais Emad

Mohammad Y.

Ali A.

Serag Eldin I.

Mohammed

Ahmed M.

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Publication Date

Wed Jan 01 2020

Journal Name

Plant Archives

The effect of temperature on cadmium adsorption and desorption in some iraqi calcareous soils

Kadhim

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(3)

Publication Date

Wed Jul 01 2020

Journal Name

Biochemical And Cellular Archives

Histopathological changes in liver induced by piroxicam administration in adult male albino mice mus musculus

Mnati I.M.

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(3)

Publication Date

Tue May 01 2018

Journal Name

Journal Of Physics: Conference Series

Pathological And Immunological Study On Infection With Escherichia Coli In ale BALB/c mice

Intisar H

Majid S

Hanady SA

Ghassan M

Ali H

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(84)

(55)

Publication Date

Tue Nov 01 2022

Journal Name

Bulletin Of National Institute Of Health Sciences

Using of Propolis on the treated rats induced with Polysystic ovarian syndrome by Litrozol drug

Propolis

ovaries

PCOS

lipid profile

Shaima R.

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Publication Date

Wed Apr 01 2020

Journal Name

Plant Archives

Effect of applying selenium element and ascorbic acid on reducing the harmful effect of environmental stress on wheat plants irrigated by water contaminated with lead and cadmium

Kadhim

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(4)

Publication Date

Sun Jun 01 2025

Journal Name

Journal Of Physics: Conference Series

Studies on The Effect of Temperature on The Charge Transfer Reaction Rate of N3 Dye When Contacted With Zinc Sulfide Semiconductor

Zainab Amjad

Mohsin A.

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Abstract<p>In this paper, the effect of temperature on the charge transfer rate of dye (N3) in contact with ZnS semiconductors is discussed and studied when electrons move from the excited N3 dye to the conduction band of ZnS based on quantum shift theory. In a heterogeneous system, the energy levels are assumed to be continuous, and the N3-ZnS system is surrounded by a variety of polar solvent media. The transition energy of the N3/ZnS heterojunction was calculated using seven different solvents at room temperature, considering the refractive index and dielectric constant of the solvents and the ZnS semiconductor, respectively. The charge-transport reaction rate was calculated over different te</p> ... Show More

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Publication Date

Sun Mar 02 2008

Journal Name

Baghdad Science Journal

The Ability of Green Tea (Camellia sinensis) Extract in Modulating the Cytogenetic and Haematological Effects of Mitomycin C in Albino Male Mice

Rakad M. Kh. Al –

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The present study aimed to investigate the toxic and mutagenic and anti – mutagenic effects of the aqueous extract (5, 10 and 15 mg/kg) of green tea (Camellia sinensis) in modulating the genotoxic effects of mitomycin C (MMC). Albino male mice (Mus musculs) were employed as a biological system and four parameters were performed in vivo; total leucocyte count, mitotic index, chromosomal aberrations and micronucleus formation. The plant extract was evaluated through three types of treatments. In the first, the extract was given alone orally. While the second and third treatment included two types of interactions with MMC; pre – and post – MMC treatments. All treatments were paralleled by negative and positive control

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Publication Date

Thu Apr 17 2008

Journal Name

Anbar Journal Of Agricultural Sciences 6 (2)‏

Influence of foliar sprays with Copper and Zinc on the resistance of citrus rootstocks to gumosis caused by Phytophthora citropthora. ‏

Moayad Rajab Abood

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