Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is used in the treatment of hypertension, angina pectoris, in addition to Parkinson disease. It goes under the BCS class II drug (low solubility-high permeability). The drug will experience extensive first-pass metabolism in liver, therefore, oral bio-availability will be approximately15 to 24 %.
The aim of this study was to formulate and optimize a stable nanoparticles of a highly hydrophobic drug, isradipine by anti-solvent microprecipitation Method to achieve the higher in vitro dissolution rate, so that it will be absorbed by intestinal lymphatic transport in order to avoid hepatic first-pass metabolism&nbs
... Show MoreDue to advancements in computer science and technology, impersonation has become more common. Today, biometrics technology is widely used in various aspects of people's lives. Iris recognition, known for its high accuracy and speed, is a significant and challenging field of study. As a result, iris recognition technology and biometric systems are utilized for security in numerous applications, including human-computer interaction and surveillance systems. It is crucial to develop advanced models to combat impersonation crimes. This study proposes sophisticated artificial intelligence models with high accuracy and speed to eliminate these crimes. The models use linear discriminant analysis (LDA) for feature extraction and mutual info
... Show MoreDarifenacin hydrobromide is a selective ?3 receptor antimuscarinic drug and it is used in the management of urinary frequency, urgency, and incontinence in detrusor instability. It slightly soluble in water, undergoes extensive hepatic first-pass metabolism and has short elimination half-life (3–4 hours). Therefore, It has low bioavailability (15.4 % - 18.6 %). Darifenacin hydrobromide loaded NLCs were formulated by emulsification sonication using different ratios of solid lipid to liquid lipid, different types of surfactants, and different concentration of surfactants. Formula sixteen was considered as an optimized formula based on its particle size, PDI, zeta potential and entrapment efficiency. Formula sixteen subjected t
... Show MoreIntelligent systems can be used to build systems that simulate human behavior. One such system is lip reading. Hence, lip reading is considered one of the hardest problems in image analysis, and thus machine learning is used to solve this problem, which achieves remarkable results, especially when using a deep neural network, in which it dives deeply into the texture of any input. Microlearning is the new trend in E-learning. It is based on small pieces of information to make the learning process easier and more productive. In this paper, a proposed system for multi-layer lip reading is presented. The proposed system is based on micro content (letters) to achieve the lip reading process using deep learning and auto-correction mo
... Show MoreImplementation of TSFS (Transposition, Substitution, Folding, and Shifting) algorithm as an encryption algorithm in database security had limitations in character set and the number of keys used. The proposed cryptosystem is based on making some enhancements on the phases of TSFS encryption algorithm by computing the determinant of the keys matrices which affects the implementation of the algorithm phases. These changes showed high security to the database against different types of security attacks by achieving both goals of confusion and diffusion.
Landsat7 of Enhanced thematic mapper plus (ETM+) was launched on April 15, 1999. Four years later, images start degrading due to the scan line corrector (SLC). SLC is a malfunction that results in pixel gaps in images captured by the sensor of Landsat7. The pixel gap regions extend from about one pixel near the image center and reach up to about 14 pixels in width near the image edge. The shape of this loss is like a zigzag line; however, there are different studies about repairing these gaps. The challenge of all studies depends on retrieving inhomogeneous areas because the homogenous area can be retrieved quickly depending on the surrounding area. This research focuses on filling these gaps by utilizing pixels around them
... Show MoreThis paper presents an architecture for the data warehouse of outpatient healthcare (DWOP) as a data repository collects data from two different sources (Databases of outpatient healthcare and Excel files from hospitals) and provides storage, functionality and responsiveness to queries to meet decision makers requirements.
Successfully supporting managerial decision-making is critically dependent upon the availability of integrated, high quality information organized and presented in a timely and easily understood manner. “On-Line Analytical Processing (OLAP) is utilized for decision support to get interesting information†from the data warehouse with a rapid execution time. OLAP is considered one of Business Intelligence
The aim of this article is to study the solution of Elliptic Euler-Poisson-Darboux equation, by using the symmetry of Lie Algebra of orders two and three, as a contribution in partial differential equations and their solutions.
Undesirable behaviors among students are consider one of the danger problems threating societies and educational and scientific institutions of countries because its one of the way to express aggression , so the instructors consider one of the most important people could be trust their evaluation and logical view , therefore the present research aimed to :
- Recognize undesirable behavior in students of University by the view of their instructors
- Measure the level of undesirable behavior in students of university by the view of their instructors
- Recognize more common undesirable behavior in students of University by the view o