Preferred Language
Articles
/
ehjKzJQBVTCNdQwCwiCL
Evaluating the effects of different doses of fimasartan on methotrexate-induced renal inflammation in rats
...Show More Authors

The nephrotoxicity induced by methotrexate is a severe condition that greatly affects its therapeutic potential and has a significant inflammatory component. Fimasartan is an angiotensin receptor blocker that offers organ-protective effects and may be useful in mitigating renal injury. The present study explored the anti-inflammatory potential of two doses of fimasartan against methotrexate-mediated nephrotoxicity. Albino rats were intraperitoneally administered a single methotrexate (20 mg/kg). Intraperitoneal treatment with fimasartan (5 or 10 mg/kg/day) was initiated on day two after methotrexate injection and continued for seven consecutive days. Methotrexate significantly increased serum urea, creatinine, and NGAL concentrations. It also substantially elevates the proinflammatory cytokines (namely, tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6) levels while reducing renal tissue’s immunomodulatory (interleukin-10) levels. Treatment with both doses of fimasartan significantly restored renal function parameters, lowered the renal concentration of proinflammatory cytokines, and upregulated the renal concentration of the anti-inflammatory mediator interleukin-10. The high fimasartan dose resulted in more pronounced effects on the inflammatory parameters. The obtained data suggested that fimasartan effectively mitigates methotrexate-induced nephrotoxicity by inhibiting inflammation in renal tissue in a dose-dependent manner.

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Sat Jan 01 2022
Journal Name
Materials Today: Proceedings
Evaluation on processing parameter's effects on some mechanical properties of pure magnesium bulk prepared by powder metallurgy
...Show More Authors

View Publication
Crossref (2)
Crossref
Publication Date
Fri Nov 01 2019
Journal Name
Journal Of Environmental Quality
Effects of Conservation Practices on Soil Quality Compared with a Corn–Soybean Rotation on a Claypan Soil
...Show More Authors

Restoration of degraded lands by adoption of recommended conservation management practices can rehabilitate watersheds and lead to improving soil and water quality. The objective was to evaluate the effects of grass buffers (GBs), biomass crops (BCs), grass waterways (GWWs), agroforestry buffers (ABs), landscape positions, and distance from tree base for AB treatment on soil quality compared with row crop (RC) (corn [Zea mays L.]–soybean [Glycine max (L.) Merr.] rotation) on claypan soils. Soil samples were taken from 10‐cm‐depth increments from the soil surface to 30 cm for GB, BC, GWW, and RC with three replicates. Soil samples were collected from

... Show More
View Publication
Scopus (19)
Crossref (17)
Scopus Clarivate Crossref
Publication Date
Fri Sep 15 2017
Journal Name
Journal Of Baghdad College Of Dentistry
Color Stability of Different Aesthetic Archwires after Immersion into Different Types of Mouthwashes(An In Vitro Study)
...Show More Authors

Background: Because of the demands for aesthetic orthodontic appliances have increased, aesthetic archwires have been widely used to meet patient's aesthetic needs. The color stability of aesthetic archwires is clinically important, any staining or discoloration will affect patient’s acceptance and satisfaction. This study was designed to evaluate the color stability of different types of aesthetic archwires after immersion into different types of mouth washes. Materials and methods: Four brands of nickel titanium coated aesthetic arch wires: Epoxy coated (Orthotechnology and G&H) and Teflon coated (Dany and Hubit) were evaluated after 1 week, 3 weeks and 6 weeks of immersion into two types of mouthwashes (Listerine with alcohol and

... Show More
View Publication Preview PDF
Crossref (2)
Crossref
Publication Date
Tue Dec 01 2020
Journal Name
International Journal Of Pharmaceutical Research
Synthesis of Some New Schiff Bases Starting from 2,2 Dimorpholinyl Acetic Acid and Evaluating the Biological activity
...Show More Authors

n this study new derivatives of Schiff bases (5-10) were synthesized from the new starting material 1 . Which has been synthesized by the reaction of (1 mol.) of dichloroacetic acid with two moles of morpholine, in the presence of potassium hydroxide, Ester derivatives 2 and 3 were synthesized by the reaction of 1 with methanol or ethanol respectively in the presence of sulphuric acid as catalyst . Compound 2 was also prepared from dimethylsulphate with high yield , 2 and 3 was used to synthesized 2,2-dimorpholinylacetohydrazide 4 via reaction with NH2NH2.H2O 80% .Imines (5-10) were synthesized via the reaction of 4 with appropriate aromatic aldehydes in the presence of G.A.A as a catalyst . Derivatives compounds (1-10) were identifie

... Show More
View Publication Preview PDF
Scopus (2)
Scopus Crossref
Publication Date
Sun Jan 30 2022
Journal Name
Iraqi Journal Of Science
Evaluating the Suitability of Groundwater for Irrigation uses at Al-Salhubia Area, Al-Muthana Governorate, Southern Iraq
...Show More Authors

Al-Salhubia, area is located within the arid region in southern Iraq. Although no surface water is available in this area, the groundwater is considered the basis in the area, it is available in both good quality and quantity. For that reason, it is of prime importance to examine water type in the unconfined aquifer to determine suitability of groundwater for irrigation purposes. The groundwater type in the studied area is Ca-Mg dominant SO4 facies according to Piper and Stiff diagrams. Based on SAR, Na%, RSC, EC, and PI, the groundwater quality in the study area is suitable for irrigation in general.

View Publication Preview PDF
Publication Date
Wed Feb 15 2023
Journal Name
Full Text Book Of Minar Congress 7
EVALUATING THE CHANGE DETECTION OF(NDVI) FOR BABYLON CITY USING REMOTE SENSING AND GIS TECHNIQUES (2015-2020)
...Show More Authors

The normalized difference vegetation index (NDVI) is an effective graphical indicator that can be used to analyze remote sensing measurements using a space platform, in order to investigate the trend of the live green vegetation in the observed target. In this research, the change detection of vegetation in Babylon city was done by tracing the NDVI factor for temporal Landsat satellite images. These images were used and utilized in two different terms: in March 19th in 2015 and March 5th in 2020. The Arc-GIS program ver. 10.7 was adopted to analyze the collected data. The final results indicate a spatial variation in the (NDVI), where it increases from (1666.91 𝑘𝑚2) in 2015 to (1697.01 𝑘𝑚2)) in 2020 between the t

... Show More
View Publication
Crossref
Publication Date
Tue Feb 11 2025
Journal Name
Journal Of Baghdad College Of Dentistry
Evaluation of the cleaning efficiency of the isthmus using different rotary instrumentation techniques (In vitro study)
...Show More Authors

Background: The aims of the study were to evaluate the unclean/clean root canal surface areas with a histopathological cross section view of the root canal and the isthmus and to evaluate the efficiency of instrumentation to the isthmus using different rotary instrumentation techniques. Materials and Methods:The mesial roots of thirty human mandibular molars were divided into six groups, each group was composed of five roots (10 root canals)which prepared and irrigated as: Group one A: Protaper system to size F2 and hypodermic syringe, Group one B: Protaper system to size F2 and endoactivator system, Group two A:Wave One small then primary file and hypodermic syringe, Group two B:Wave One small then primary file and endoactivator system, Gr

... Show More
View Publication Preview PDF
Publication Date
Thu Jan 01 2015
Journal Name
International Journal Of Pharmacy And Pharmaceutical Sciences
Study the sustain release effect of different polymers used in the formulation of aspirin-rosuvastatin tablets
...Show More Authors

Scopus (4)
Scopus
Publication Date
Wed Dec 01 2021
Journal Name
Journal Of Physics: Conference Series
Analytical Study of the Royal-Jelly Effect on Sperms Morphological Characteristics and some Liver Function Parameters and their Correlation with some Antioxidants in Male Albino Rats Treated with Pregabalin Drug
...Show More Authors
Abstract<p>In recent years, the consideration of natural products as anti-inflammatory and antioxidative treatments has more interested worldwide. Moreover, natural products are easily obtained and are relatively safe the Royal jelly (RJ) is one of them. The current study was carried to evaluate the effects of pregabalin (PGB) on physiological activity of sperms, reproductive hormones assay and some biochemical analysis. Forty (40) male albino rats (10-weeks-old) were divided into four groups (10 rats each): G1 (treated with PGB drug, 150 mg/kg B.wt (Lyrica-Pfizer-Pharmaceutical Industries), G2 (treated with RJ 1g/kg), G3 (treated with PGB drug and RJ together), and G4 control treated with norma</p> ... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Thu Jan 06 2011
Journal Name
Arpn Journal Of Agricultural And Biological Science
EFFECT OF FEEDS CONTAINING DIFFERENT FATS ON CERTAIN CARCASS PARAMETERS OF JAPANESE QUAIL
...Show More Authors

The aim of this study was to determine the effect of different dietary fat on carcass traits in Japanese quail (Coturnix coturnix japonica). A total of 168 7-week-old Japanese quail (48 males and 120 females) were used in this study. They were evenly distributed into 4 treatment groups, with 3 replicates per group containing 4 males and 10 females each. The birds were fed a basal diet with different fats (sunflower, flax, corn, and fish oils) at a 3% level for 13 weeks. On the last day of the experiment, 12 birds were randomly selected from each treatment group (6 males and 6 females) and slaughtered to determine carcass characteristics included in this study, which were carcass weight, dressing percentage with or without giblets, and the r

... Show More
View Publication Preview PDF