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Possible Protective Anticancer effect of Ethanol Fraction of Iraqi Hibiscus Tiliaceus L. Leaves Extract on Diethylnitrosamine-induced Hepatocarcinogenesis in Male Rats
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Abstract  Liver cancer with hepatocellular carcinoma a serious clinical illness that progresses quickly and has a bad prognosis because to increased malignancy. Fibrosis is the precursor of liver cancer, which progresses to cirrhosis and carcinoma Diethylnitrosamine (DEN) is a chemical molecule that has been used as a carcinogenic agent to promote cancer in test animals because of its strong carcinogenic potential. Herbal plants have long been used as inexpensive, effective alternatives to pharmaceuticals in various liver-associated complications, since they contain many bioactive compounds useful in liver disorders. Hibiscus tiliaceus L. (Malvaceae) contain various phytochemicals in the plant extracts such as Flavonoids, phenols, alkaloids, Tannins, Saponins, Quinones, Coumarine, Triterpenoids, glycosides and Steroids. Thus, has various health benefits, and have medicinal and therapeutic values, It could be a source of natural antioxidants, antimicrobials, hepatoprotective compounds, and antimutagenic effects. The study was designed To study the possible protective role of Iraqi Hibiscus tiliaceus L. ethanol leaves extract administered in two different doses on diethylnitrosamine induced liver carcinoma in male Wistar Albino rats. Rats utilized in this study were randomized into 4 groups (six rats per each group); Group I: (Control) Rats were administered oral daily dose of 1ml /kg/day of distilled water for 20 weeks; Group II: rats intraperitoneally injected with 70 mg/kg diethyl nitrosamine once per week for 10 continuous weeks; Group III: Rats were administered 250mg/kg of Iraqi Hibiscus tiliaceus L.  ethanol leaves extract as chronic oral administration with food for 5 days per week for 20 weeks and subsequently intraperitoneal dose of diethylnitrosamine (70 mg/kg) once per week for 10 continuous weeks; Groups IV: Rats were administered 500mg/kg of Hibiscus tiliaceus L. ethanol leaves extract as chronic oral administration with food for 5 days per week for 20 weeks with subsequently intraperitoneal dose of diethylnitrosamine (70 mg/kg) once per week for 10 continuous weeks. The finding revealed that Iraqi Hibiscus tiliaceus L.  ethanol leaves extract showed significant reduction (P<0.05) in malondialdehyde, alpha fetoprotein (AFP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), total bilirubin (TSB), pro-inflammatory cytokines include transforming growth factor beta (TGFβ), tumor necrosis factor alpha (TNFα) and significant elevation (P<0.05) of anti-oxidant enzyme superoxide dismutase (SOD) in dose dependent manner. In conclusion this study demonstrated that the chemoprotective role of Hibiscus tiliaceus L. ethanol leaves extract might be explained by; lowered levels of hepatic enzymes, pro-inflammatory cytokines, and antioxidant levels, as well as decreased levels of alpha fetoprotein (AFP), the gold standard for detecting hepatocellular carcinoma.

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Publication Date
Fri Sep 01 2023
Journal Name
Asian Pacific Journal Of Cancer Prevention
Development of a T-ARMS-PCR Assay for Detecting Genetic Polymorphism in the Catalase (rs7943316) Gene in the Iraqi Population with Breast Cancer
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Publication Date
Fri Sep 30 2022
Journal Name
Modern Sport
A historical study of the Iraqi national team’s participation in the blind men’s goalball in the Asian Championships for the period (2014-2022)
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من الاهمية دراسة التاريخ كونه يمدنا بحلول للمشكلات المعاصرة في ضوء خبرات الماضي، ودراسة سلبيات وايجابيات هذه الحلول، وانطلاقا من مبدأ أن ذوي الإعاقة البصرية طاقة بشرية لابد من استثمارها بما يخدم تقدم وازدهار المجتمع، فمن الأهمية تسليط الضوء على هذه الفئة والإسهام بنقل صورة مشرفة عنها، قد تكون دافعا للآخرين ممن اوقفهم انطفاء شعاع النور والبصيرة عن اكمال حياتهم لشرارة امل تعيد لهم شغفهم في الحياة، وته

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Publication Date
Sun Dec 01 2019
Journal Name
Plant And Archeaf
EFFECT OF SPRAYING IRON AND ZINC CONCENTRATIONS IN GRAIN AND LEAF CONTENT FOR TWO VARIETIES OF WHEAT CROP
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EFFECT OF SPRAYING IRON AND ZINC CONCENTRATIONS IN GRAIN AND LEAF CONTENT FOR TWO VARIETIES OF WHEAT CROP

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Publication Date
Tue Mar 01 2011
Journal Name
Journal Of Economics And Administrative Sciences
Effect of Financial Performance of Jordanian Islamic Banks In the Amman Stock Exchange for the period (1990-2008)
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The last four decades have witnessed a number of rapid and successive international changes in terms of future impacts and orientations. International economy has transformed into a competitive small village due to the information technology revolution and the liberation processes and the economic openness that the market witnesses, there became one market and the activists in this international market are not governments only but rather international organizations and huge multinational corporations where each spares no effort to take every opportunity and face challenges within the frame of  removing all impediments and release transactions under the auspices of  these global developments, the idea of creating Islamic

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Publication Date
Fri Jan 01 2021
Journal Name
International Journal Of Psychosocial Rehabilitation
The effect of attacking tactical skill exercises in the skills of dribbling and shooting for youth football players
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Publication Date
Tue Dec 22 2020
Journal Name
Lecture Notes In Civil Engineering
Evaluating the Performance of Flexible Passive Pile Group in Cohesionless Soil Under the Effect of a Nearby Embankment
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Publication Date
Tue Mar 20 2018
Journal Name
Mustansiria Dental Journal
A comparative Study in the Antibacterial effect of Eugenol as Hand Wash Material with two Types of Soap
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Hands have consistently been an important vehicle in the transmission of disease (1). Thus, thorough hand-washing remains the single most important factor in preventing infection specially in hospitals and labs.Twenty-nine non-clinical volunteers (do not work or come in contact with a clinical or hospital setting) that lacked visible skin injuries, eczema or apparent skin disease were used, those subjects were all tested by a material of each of the three used in the study weekly and laboratory tests were done pre- and post washing.All three material were effective , Eugenol extract as effective as the bar and lotion soap. And this was confirmed statistically.Eugenol has a great antibacterial action even in small concentration and t

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Publication Date
Thu Nov 14 2024
Journal Name
Journal Of Studies And Researches Of Sport Education
The effect of Rondo exercises in developing some basic skills for futsal players under the age of 18
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The Journal of Studies and Researches of Sport Education (JSRSE)

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Publication Date
Thu Jan 01 2015
Journal Name
Chemistry And Materials Research
Synthesis, Physico-Chemical and Antimicrobial Activities Co(II),Ni (II) ,Cu(II), Zn(II),Cd(II) and Hg(II) Mixed- Ligand Complexes of L- Alanine and Trimethoprim Antibiotic
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The Co (II), Ni (II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid (L-Alanine ) and Trimethoprim antibiotic were synthesized. The complexes were characterized using melting point, conductivity measurement and determination the percentage of the metal in the complexes by flame (AAS). Magnetic susceptibility, Spectroscopic Method [FTIR and UV-Vis]. The general formula have been given for the prepared mixed ligand complexes [M(Ala)2(TMP)(H2O)] where L- alanine (abbreviated as (Ala ) = (C5H9NO2) deprotonated primary ligand, L- Alanine ion .= (C5H8NO2 -) Trimethoprim (abbreviated as (TMP ) = C10H11N3O3S M(II) = Co (II),Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II). The results showed that the deprotonated L- Alanine by KOH (Ala

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Publication Date
Mon Jul 04 2022
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
The possibility of adopting strategic management accounting techniques to increase competitiveness Iraqi economic units in light of the variables of the contemporary business environment.
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The accession of countries to the World Trade Agreement and the openness of markets to each other without restrictions led to the emergence of the philosophy of "a world without borders and business units without countries", which required adapting the modern business environment to that philosophy, which is considered as objectives for the activities of the units that must be implemented in order to achieve competition. The objective of the units has changed from making profit to meeting the desires of customers, which is what imposed a new role for management accounting as a field of knowledge renewed in it visions of competitiveness between units. Because of the increasing needs for information in light of environmental change

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