Abstract Liver cancer with hepatocellular carcinoma a serious clinical illness that progresses quickly and has a bad prognosis because to increased malignancy. Fibrosis is the precursor of liver cancer, which progresses to cirrhosis and carcinoma Diethylnitrosamine (DEN) is a chemical molecule that has been used as a carcinogenic agent to promote cancer in test animals because of its strong carcinogenic potential. Herbal plants have long been used as inexpensive, effective alternatives to pharmaceuticals in various liver-associated complications, since they contain many bioactive compounds useful in liver disorders. Hibiscus tiliaceus L. (Malvaceae) contain various phytochemicals in the plant extracts such as Flavonoids, phenols, alkaloids, Tannins, Saponins, Quinones, Coumarine, Triterpenoids, glycosides and Steroids. Thus, has various health benefits, and have medicinal and therapeutic values, It could be a source of natural antioxidants, antimicrobials, hepatoprotective compounds, and antimutagenic effects. The study was designed To study the possible protective role of Iraqi Hibiscus tiliaceus L. ethanol leaves extract administered in two different doses on diethylnitrosamine induced liver carcinoma in male Wistar Albino rats. Rats utilized in this study were randomized into 4 groups (six rats per each group); Group I: (Control) Rats were administered oral daily dose of 1ml /kg/day of distilled water for 20 weeks; Group II: rats intraperitoneally injected with 70 mg/kg diethyl nitrosamine once per week for 10 continuous weeks; Group III: Rats were administered 250mg/kg of Iraqi Hibiscus tiliaceus L. ethanol leaves extract as chronic oral administration with food for 5 days per week for 20 weeks and subsequently intraperitoneal dose of diethylnitrosamine (70 mg/kg) once per week for 10 continuous weeks; Groups IV: Rats were administered 500mg/kg of Hibiscus tiliaceus L. ethanol leaves extract as chronic oral administration with food for 5 days per week for 20 weeks with subsequently intraperitoneal dose of diethylnitrosamine (70 mg/kg) once per week for 10 continuous weeks. The finding revealed that Iraqi Hibiscus tiliaceus L. ethanol leaves extract showed significant reduction (P<0.05) in malondialdehyde, alpha fetoprotein (AFP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), total bilirubin (TSB), pro-inflammatory cytokines include transforming growth factor beta (TGFβ), tumor necrosis factor alpha (TNFα) and significant elevation (P<0.05) of anti-oxidant enzyme superoxide dismutase (SOD) in dose dependent manner. In conclusion this study demonstrated that the chemoprotective role of Hibiscus tiliaceus L. ethanol leaves extract might be explained by; lowered levels of hepatic enzymes, pro-inflammatory cytokines, and antioxidant levels, as well as decreased levels of alpha fetoprotein (AFP), the gold standard for detecting hepatocellular carcinoma.
Purepolyaniline and doped with hydrochloric acid was prepared in different molarities at room temperature. The a.c electrical properties were stadied.AC conductivityσac (ω), is found to vary as ωS in the frequency range (100Hz-10MH), S< 1and decreases indicating a dominate hopping process. Thedielectric constant ε1and dielectric loss ε2 have been determined for bulk polyaniline. ε1 decrease with the increase frequency. Electrical conductivity measurements increase with the increases both of the amount of HCl and the dose of radiation. The dielectric investigations show decrease with dose radiation.
Zinc-indium-selenide ZnIn2Se4 (ZIS) ternary chalcopyrite thin film on glass with a 500 nm thickness was fabricated by using the thermal evaporation system with a pressure of approximately 2.5×10−5 mbar and a deposition rate of 12 Å/s. The effect of aluminum (Al) doping with 0.02 and 0.04 ratios on the structural and optical properties of film was examined. The utilization of X-ray diffraction (XRD) was employed to showcase the influence of aluminum doping on structural properties. XRD shows that thin ZIS-pure, Al-doped films at RT are polycrystalline with tetragonal structure and preferred (112) orientation. Where the
Aluminum doped zinc selenide ZnSe/n-Si thin films of (250∓20 nm) thickness with (0.01, 0.02 and 0.03), are depositing on the two type of substrate (glass and n-Si) to manufacture (ZnSe/n-Si) solar cell through using thermal vacuum evaporation procedure. physical and optoelectronic properties were examined for the samples. X-Ray and AFM techniques are using to study the structure properties. The energy band gap of as-deposited ZnSe thin films for changed dopant ratio were ranging from (2.6-2.68 eV). The results of Hall effect show that pure and doping films were (p-type), and the concentration carriers and the carriers mobility increases with increase Al-dopant ratio. The (C-V) have shown that the heterojunction were of abrupt type. In add
... Show MoreZinc Oxide (ZnO) thin films of different thickness were prepared
on ultrasonically cleaned corning glass substrate, by pulsed laser
deposition technique (PLD) at room temperature. Since most
application of ZnO thin film are certainly related to its optical
properties, so the optical properties of ZnO thin film in the
wavelength range (300-1100) nm were studied, it was observed that
all ZnO films have high transmittance (˃ 80 %) in the wavelength
region (400-1100) nm and it increase as the film thickness increase,
using the optical transmittance to calculate optical energy gap (Eg
opt)
show that (Eg
opt) of a direct allowed transition and its value nearly
constant (~ 3.2 eV) for all film thickness (150
This study offers the elastic response of the variable thickness functionally graded (FG) by single walled carbon nanotubes reinforced composite (CNTRC) moderately thick cylindrical panels under rotating and transverse mechanical loadings. It’s considered that, three kinds of distributions of carbon nanotubes which are uniaxial aligned in the longitudinal direction and two functionally graded in the transverse direction of the cylindrical panels. Depending on first order shear deformation theory (FSDT), the governing equations can be derived. The partial differential equations are solved by utilizing the technique of finite element method (FEM) with a program has been built by using FORTRAN 95. The results are calculat
... Show MoreABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet.Results: In vitro release show
... Show MoreEarth dams in regions with moderate to high seismic activity are crucial for protecting downstream communities. Iraq and its neighboring areas have seen recurrent seismic activity, notably the 2017 Halabja Earthquake, which potentially compromised the integrity of the existing earth dam. The Darbandikhan Dam, affected by an earthquake, has inadequacies in its crest and downstream slope, presenting a greater danger of significant earthquake-induced damage compared to cyclic shocks. Consequently, evaluating the dam's safety is essential for safeguarding downstream residents and identifying optimal ways to avert slope stability failure amid recurrent seismic activity. Iraq's seismicity map is being updated to reflect earthquake magni
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