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Circulating miR-126-3p and miR-423-5p Expression in de novo Adult Acute Myeloid Leukemia: Correlations with Response to Induction Therapy and the 2-Year Overall Survival
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Abstract Background: Acute myeloid leukemia (AML) results from sequential genetic alterations in a normal hematopoietic stem cell or its progenitors giving rise to an autonomous clone that dominates the bone marrow leading to marrow failure. MicroRNAs are short non-coding nucleic acid sequences that regulate post-transcriptional gene expression by base-pairing with their target mRNAs. MiRNAs can be secreted into extracellular fluids and carried to target cells by vesicles or bound to proteins. Intracellular and circulating miRNAs are believed to be useful markers in the diagnosis, prognosis, and treatment of various cancers. Practically, circulating miRNAs are more stable at room temperatures and extreme conditions. Purpose: This study aimed to compare the expression of miR-126-3p and miR-423-5p in patients and normal subjects and correlate their expression with response to induction therapy and with their 2-year overall survival rate. Patients and methods: Circulating miR-126-3p and miR-423-5p was measured in the plasma of 43 adult AML patients and 35 age- and sex-matched controls by quantitative reverse transcriptase PCR. The fold change in differential expression for each gene was calculated using the comparative cycle threshold method. Results: There was an increase in the expression of the studied miRNAs in patients compared to the control group. The average expression fold change of miR-126-3p was 3.02 (p= 0.010). The average expression fold change of miR-423-5p was 4.09 (p= 0.003). No significant correlation was found between the expression of miR-126-3p and miR-423-5p in the studied AML patients (r = 0.094, p = 0.22). Furthermore, no relationship was found between the expression of the studied miRNAs and response to induction therapy or the 2-year survival rate. Conclusion: Although further studies are needed, our findings highlight the studied circulating miRNAs as possible diagnostic markers for AML.

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Publication Date
Sat Aug 15 2015
Journal Name
Chemistry And Materials Research
Synthesis and Characterization of 3, 5-Dimethyl-2-(4-nitrophenyl azo)-Phenol Complexes with Co (II) and Ni (II) and Study Its Effect on the Activity of Ach Enzyme (invitro)
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Publication Date
Fri Jun 01 2012
Journal Name
Journal Of The College Of Languages (jcl)
An Investigation of Iraqi Fourth-Year University Students’ Recognition of Presupposition Through The Linguistic Triggers
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Presupposition is the background belief that is known by both the speaker and the addressee, it is tied to particular words and aspects of the surface structure that act as linguistic triggers. The present study aims at investigating whether Iraqi fourth -year university students are able to recognize the English presuppositions through the meaning of these linguistic triggers .To fulfil the basic requirements of the study, the researcher has conducted a test . The results of the study have validated the hypothesis of the work and it is found that the linguistic triggers are important tools in recognizing presuppositions.    

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Publication Date
Sun Apr 01 2018
Journal Name
Al–bahith Al–a'alami
Investment of Propaganda in Al-Rafidain and Al- Sharqiya News Channels: Content Analysis of News Bulletins from 1/12/2016 to 29/2/2016
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The technological developments in the field of communication have witnessed considerable impact in the variables which exist in following up and conveying the events which link it’s meaning to political implications. This makes a number of satellite channels depend on the techniques of propaganda and use them in the news bulletins to achieve political aims and ends related to its formational directives where those channels allotted a considerable time in its programming transmission map to concentrate on the security and political status to complete the image of the informational scene according to the logic of its propaganda and styles in processing news for daily events.The technological developments in the field of communication hav

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Publication Date
Sat Feb 09 2019
Journal Name
Journal Of The College Of Education For Women
Diversity of Morphological and Syntactic Aspects in the Holy Quran with Reference to the Verse "Have we not made the earth a receptacle"
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Diversity of the aspects of analyzing a specific linguistic issue is considered to be a
familiar phenomenon in learning Arabic in which – at different levels- various linguistic
aspects and phases – sometimes – are involved in a linguistic issue . In this paper , the
problematic issues during linguistic analysis are taken into an account. The Holy Quran
interpretation books include many Quranic expressions which have a lot of meaning described
by different interpreters , from them this paper has selected only one expression ( = كفاتا
receptacle ) from the verse "Have we not made the earth a receptacle " ( Al- Mursalat verse 25
) , this paper believes that this expression is sufficient display the interpret

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Publication Date
Fri Jul 01 2011
Journal Name
Bulletin Of The Iraq Natural History Museum (p-issn: 1017-8678 , E-issn: 2311-9799)
CAVE DWELLING ANIMALS IN IRAQ PART 2: SYSTEMATIC NOTES ON THE NUTHATCH OF THE FAMILY SITTIDAE (AVESPASSERIFORMES) IN IRAQ WITH ADDING SOME IMPORTANT KNOWLEDGE TO THE NEST BUILDING OF SITTATEPHRONOTA SHARPE, FROM BESAN VALE HAWRAMAN SLOPE, IRAQI KURDISTAN
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This paper is a review of the genus Sitta in Iraq, Five species of this genus are recognized
Sitta kurdistanica, S. neumayr, S. europaea, S.dresseri and S. tephronota. Geographical
distribution and systematic nots were given for separation and identification, also some notes
on nest building and nest sites of S. tephronota supporting by figures are presented.

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Publication Date
Thu Jun 01 2017
Journal Name
Journal Of The College Of Languages (jcl)
Realismo y tradicionessocioculturales en “Bodas de sangre”
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Resumen

El trabajo se investiga en el realismo y la tradición social que incluye la tragedia Bodas de sangre, del autor español Federico García Lorca. A lo largo de estas páginas se da la luz sobre los temas, acciones, oraciones y palabras que pertenecen a la realidad de la vida española en general y sobre todo en territorio andaluz, en el que ocurren los sucesos de la obra.  Así como las tradiciones sociales que el dramaturgo español contemporáneo abundando a lo largo de su texto, y que han sido tomadas de la herencia popular.

    Literariamente, esta obra se clasifica como Tragedia Moderna, por la razón de que incorpora los elementos necesarios de d

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Publication Date
Sun Nov 30 2014
Journal Name
Journal Of The College Of Languages (jcl)
Dificultades de traducción en los textos teatrales
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Publication Date
Wed Jun 01 2016
Journal Name
Journal Of The College Of Languages (jcl)
LA TRADUCCIÓN DE LOS REFRANES: PROBLEMAS SOLUCIONES
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Resumen:

        La traducción de los refranes, que son unas sentencias breves, habitualmente, de autor desconocido y lo mismo que el proverbio, aunque en su parte universalizable refleja una experiencia humana, hace referencia en parte particularizante e idiosincrática a una experiencia sin paralelo en la lengua de destino, no es una tarea tan sencilla ni tan fácil como piensan muchas personas, sino al contrario por completo, es algo tan difícil y tan complicado. Por eso, la traducción de los refranes  no es una transferencia de un significado, un párrafo o una frase de un cierto idioma a otro, porque si aceptamos ese concepto, el proceso de traducción de refranes sería muy sencill

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Publication Date
Tue Dec 15 2020
Journal Name
Alustath Journal For Human And Social Sciences
L’œuvre de Marguerite Duras vue en Irak
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L'écrivaine française Marguerite Duras, née en Indochine en 1914, est considérée comme l'un des écrivains dont les œuvres se distinguent par la nouveauté. Cela lui accorde une grande renommée depuis le début de ses écrits. Il est vrai que Duras n’était pas une théoricienne, mais certains l'a mise avec les romanciers du Nouveau Roman comme Alain Robbe-Grillet, Nathalie Sarraute et Michel Butor. D’autres critiques l’étudient  en fonction de la modernité qui caractérise ses œuvres littéraires.

Cette recherche étudie la réception des œuvres littéraires de Marguerite Duras en Irak. L'étude comprend une introduction au roman en Irak : ses ressources, son développement, et l'effet du roman étrang

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Publication Date
Wed Jan 01 2014
Journal Name
Journal Of The College Of Languages (jcl)
Dificultades de traducción en los textos teatrales
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The theatrical text is a literary genre is written to be represented on a stage. Present difficulties in translation because include elements paralinguistic, historical, social, cultural, etc. The drama contains dialect, slang, and jargon elements. Here the translator must decide in favor of a re-creation of such elements with dialects, slang, and jargon in the receiving.

    The main objective of this study presents a descriptive about the translation for the theater and the main problems in translation theatrical texts. Try to reach some conclusions about the following questions: What requires theatrical translation? and What is the perfect formation of the translator of theater texts?.  The first part is an

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