Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.

Path planning in autonomous robotic systems (ARS) is challenging, especially in dynamic or uncertain environments. Many classical methods are computationally expensive and lack adaptability to real-world scenarios. In order to improve the overall path-planning capabilities of robots; this paper introduces a new smart robotic navigation system which uses Software Defined Network (SDN) and Multi-Spike Elman Neural Network (MS-ENN). The introduced system includes an innovative way to encode temporal information using multiple spikes which can capture much greater amounts of detail about changing environmental characteristics than conventional artificial neural networks. Additionally, it includes a spiking wave-front planner (SWP) to pr

he aim of this study is to get a plant extracts to use it as molluscicides to control the snail vector of Schistosomiasis andfinely control the disease. Laboratory study was performed to compare the molluscicidal activity of leaves and stems extractsof Cucumis melo against Bulinus truncatus snail. The snail B. truncatus was exposed to a serial concentrations of leaves andstems extracts (4000ppm, 5000ppm) in this work. Different effects of the extracts to the snail B. truncatus were recorded.These effects includes death, escaping and imbalance of snail behavior. 96hr-LD50 values of leaves extracts were calculatedfor the doses 4000 and 5000ppm as (76 and 37%) respectively while for stems were (105 and 47%) respectively. We found thatthe snail

This work presents a canned-food defect-detection method using the EfficientDet model with four backbones (MobileNet, EfficientNet, Swin-T, and ConvNeXt). The dataset included 8046 images with a resolution of 512 × 512 pixels. The performance criteria in this study accuracy “mAP”, computational cost “FLOPs”, and Frames Per Second “FPS”. The lightweight backbone with EfficientDet achieves a mean Average Precision (mAP) of 90% with MobileNet, while EfficientNet achieves mAP accuracy of 92% and 94%. The heavy backbone for EfficientDet (Swin-T, and ConvNeXt) achieves mAP accuracy of 96% and 98%. The main contribution of this study is to optimize the speed of conveyor belts in industrial production lines to considers the

The Combined Economic Emission Dispatch (CEED) problem is crucial for optimizing power system operation by minimizing costs and emissions while ensuring grid stability and meeting demand. This paper addresses the complex, nonlinear, and nonconvex nature of CEED, arising from factors like valve-point effects and transmission losses, which necessitates efficient metaheuristic algorithms. We introduce an Improved Zebra Optimization Algorithm (IMZOA), an enhanced bio-inspired technique integrating advanced adaptive foraging and dynamic defense mechanisms, along with a cubic function for CEED modeling, to improve search efficiency and convergence. IMZOA demonstrates significant numerical improvements, achieving up to a 0.80 % cost reduction for

This study delves into the design optimization of a hydropower harvesting system, exploring various parameters and their influence on system performance. By modifying the variables within the model to suit different flow conditions, a judiciously optimized design is attainable. Notably, the lift force generated is found to be intricately linked to the strategic interplay of the bluff body's location, cylinder dimensions, and flow velocity. The findings culminate in the establishment of empirical equations, one for lift force and another for displacement, based on the force equation. Many energy harvesting approaches hinge on the reciprocating motion inherent to the structural system. The methodology developed in this study emerges as a pot