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Molecular Analysis of CYP21A2 Gene Mutations among Iraqi Patients with Congenital Adrenal Hyperplasia
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Congenital adrenal hyperplasia is a group of autosomal recessive disorders. The most frequent one is 21-hydroxylase deficiency. Analyzing CYP21A2 gene mutations was so far not reported in Iraq. This work aims to analyze the spectrum and frequency of CYP21A2 mutations among Iraqi CAH patients. Sixty-two children were recruited from the Pediatric Endocrine Consultation Clinic, Children Welfare Teaching Hospital, Baghdad, Iraq, from September 2014 till June 2015. Their ages ranged between one day and 15 years. They presented with salt wasting, simple virilization, or pseudoprecocious puberty. Cytogenetic study was performed for cases with ambiguous genitalia. Molecular analysis of CYP21A2 gene was done using the CAH StripAssay (ViennaLab Diagnostics) for detection of 11 point mutations and >50% of large gene deletions/conversions. Mutations were found in 42 (67.7%) patients; 31 (50%) patients were homozygotes, 9 (14.5%) were heterozygotes, and 2 (3.2%) were compound heterozygotes with 3 mutations, while 20 (32.3%) patients had none of the tested mutations. The most frequently detected mutations were large gene deletions/conversions found in 12 (19.4%) patients, followed by I2Splice and Q318X in 8 (12.9%) patients each, I172N in 5 (8.1%) patients, and V281L in 4 (6.5%) patients. Del 8 bp, P453S, and R483P were each found in one (1.6%) and complex alleles were found in 2 (3.2%). Four point mutations (P30L, Cluster E6, L307 frameshift, and R356W) were not identified in any patient. In conclusion, gene deletions/conversions and 7 point mutations were recorded in varying proportions, the former being the commonest, generally similar to what was reported in regional countries.

Scopus
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Publication Date
Fri May 01 2015
Journal Name
Journal Of Physics: Conference Series
Spectrum of Secondary Submodules
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Scopus (2)
Scopus
Publication Date
Sun Jun 30 2013
Journal Name
Al-kindy College Medical Journal
Huge Chondrosarcoma of Shoulder
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Background: Chondrosarcoma is the second most frequent primary malignant tumor of bone. It is considered relatively an uncommon tumor. Generally it is not common for chondrosarcoma to attend huge size; however, one type was described as mesenchymal chondrosarcoma of low grade cartilaginous cells, with female predominance which can grow to exceptionally large size. Case Presentation: We report a case of Chondrosarcoma, in 30 years old woman of 4 years duration, with a huge mass (weighted 16 Kg) and roughly measured 40x30 x20cm, around the right shoulderInvestigations: Repeated MRI of the shoulder and trunk revealed a clear plane of cleavage between the tumor mass and the chest and abdominal walls and absence of invasion of the abdomen. Ul

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Publication Date
Sun Dec 31 2000
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Preparation of Tartaric Acid
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Publication Date
Sun Apr 02 2017
Journal Name
Journal Of Educational And Psychological Researches
Philosophical origins of psychology
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Since the beginning of Philosophical thinking, philosophers had interested in matters that related to psychology. Greek philosophy had sought different psychological cases such as knowledge, thought, sense, and cognition. Plato classified cognitive processes and distinguished between intelligence, emotions, and desires. As Aristotle believed that soul is the essence of human beings that characterize it from other creatures. Regarding the European philosophy, Descartes linked the optics field to psychology that comprises theories about visual perception. Then, john Watson who interested in behaviorism, he believes that the interpretation of behavior will be materialistic. However, the evolutionary view had great effect on psychology that

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Publication Date
Wed Dec 30 2015
Journal Name
College Of Islamic Sciences
Investment of Zakat funds
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Zakat funds may be invested by the owner or his agent, because there is a delay in the investment, and such delay may harm the beneficiaries.
The scholars agreed on the permissibility of investment if it is received from those who are entitled to zakat after it is received, because if zakat reaches their hands, they become wholly owned by them, and therefore they may dispose of it as the disposition of the owners in their property, like all other permissible acts that are permissible according to shariah. What you will see in the folds of the search, God willing).

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Metaphysics of theater performance
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The research explores through its three parts, to search for the unconscious and the collective unconscious in order to identify the per-formative stimuli and motives and their motivation to produce a performance that is consistent with the metaphysics of the myth or the epic and its different characters from other human characters. The paper also explores in its second section a sort of sacred performance energy. Together, along with motivating the mind and engaging the subconscious, comes a metaphysical text and with its characters and epic events.

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Crossref
Publication Date
Thu Sep 30 2021
Journal Name
College Of Islamic Sciences
Augustine’s theory of knowledge
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The issue of epistemology is one of the theological issues that were and still is a relentless pursuit of knowledge, knowing the true knowledge of certainty. Therefore, it formed a main focus because of its great importance expressing the deep desire of the human soul to explore the self and reality and answer all the questions that it may raise. Knowledge is the highest function. For man to exist.

Therefore, the establishment of epistemology was general in knowledge, a characteristic that was distinguished, as it is an ancient and renewed subject that is still being raised and raised, although there are many methods of treating it and sacred solutions to it. To finally prove its potentia

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Publication Date
Sat Jan 01 2022
Journal Name
Science Archives
Medical application of Chitosan
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By using the deacetylation method, chitin is converted into bioproduct chitosan. Deacetylation can be accomplished using chemical or biological mechanisms. Due to its biocompatibility, nontoxicity, biodegradability, natural origin, and resemblance to human macromolecules, it is useful in medicine. Chitosan may have antibacterial and antioxidant properties. Additionally, it could be used in biotechnology, agriculture, gene therapy, food technology, medication delivery, cancer therapy, and other fields. The objective of the current review was to list the most significant applications of Chitosan in the biomedical field.

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Crossref
Publication Date
Thu Nov 30 2023
Journal Name
المجلة العراقية للبحوث الانسانية والاجتماعية والعلمية
Issues of contemporary jurisprudence
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Islamic jurisprudence is a divine approach capable of confronting all developments that occur in human society and giving appropriate solutions to them. The research discussed opinions related to some contemporary issues according to the rule of no excess or negligence and according to the rules of removing hardship and facilitating in order to reach the appropriate legal ruling for the nature of the situation to which it may be exposed. Man is in paradise, and the research emphasizes the necessity of taking into account the aspect of precaution when deciding on issues, such as the rules of change and the removal of embarrassment

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Publication Date
Tue Feb 01 2022
Journal Name
Journal Of Physics: Conference Series
Study the effect of gamma Irradiation on the Superconducting Properties of HgBaSrCa2Cu3O8+δ
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