Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is  used in the treatment of hypertension, angina pectoris, in addition to Parkinson disease. It goes under the BCS class II drug (low solubility-high permeability). The drug will experience extensive first-pass metabolism in liver, therefore, oral bio-availability will be approximately15 to 24 %.

 The aim of this study was to formulate and optimize a stable  nanoparticles of a highly hydrophobic drug, isradipine by anti-solvent microprecipitation Method to achieve the higher in vitro dissolution rate, so that it will be absorbed by intestinal lymphatic transport in order to avoid hepatic first-pass metabolism&nbs

Darifenacin hydrobromide is a selective ?₃ receptor antimuscarinic drug and it is used in the management of urinary frequency, urgency, and incontinence in detrusor instability. It slightly soluble in water, undergoes extensive hepatic first-pass metabolism and has short elimination half-life (3–4 hours). Therefore, It has low bioavailability (15.4 % - 18.6 %). Darifenacin hydrobromide loaded NLCs were formulated by emulsification sonication using different ratios of solid lipid to liquid lipid, different types of surfactants, and different concentration of surfactants. Formula sixteen was considered as an optimized formula based on its particle size, PDI, zeta potential and entrapment efficiency. Formula sixteen subjected t

     Intelligent systems can be used to build systems that simulate human behavior. One such system is lip reading. Hence, lip reading is considered one of the hardest problems in image analysis, and thus machine learning is used to solve this problem, which achieves remarkable results, especially when using a deep neural network, in which it dives deeply into the texture of any input. Microlearning is the new trend in E-learning. It is based on small pieces of information to make the learning process easier and more productive. In this paper, a proposed system for multi-layer lip reading is presented. The proposed system is based on micro content (letters) to achieve the lip reading process using deep learning and auto-correction mo

      Landsat7 of Enhanced thematic mapper plus (ETM+) was launched on April 15,  1999. Four years later, images start degrading due to the scan line corrector (SLC). SLC is a malfunction that results in pixel gaps in images captured by the sensor of Landsat7. The pixel gap regions extend from about one pixel near the image center and reach up to about 14 pixels in width near the image edge. The shape of this loss is like a zigzag line; however, there are different studies about repairing these gaps. The challenge of all studies depends on retrieving inhomogeneous areas because the homogenous area can be retrieved quickly depending on the surrounding area. This research focuses on filling these gaps by utilizing pixels around them