This study presents a histological comparison of the esophagus between squirrels and mongooses, illustrating herbivorous and carnivorous dietary adaptations, respectively. Histological sections were examined from both species to compare the tunica mucosa, submucosa, muscularis, and adventitia. Esophageal samples were collected from adult specimens that were stained with hematoxylin and eosin (H&E) and Masson’s trichrome, then examined microscopically. Results revealed that squirrels exhibited a thick wall with non-keratinized epithelium and fully striated muscularis, reflecting a plant-based diet. In contrast, mongooses displayed regional variation in wall thickness and thinner mucosa in the upper third and a transition from striated to smooth muscle along the esophagus that suited their diet. Vascularization in the submucosa also differed significantly between species. These findings enhance the understanding of the relationship between esophageal histology and feeding ecology in these mammals and contribute to broader knowledge of the evolutionary patterns of the digestive system in response to dietary specialization.
