Thyroid disease is a common disease affecting millions worldwide. Early diagnosis and treatment of thyroid disease can help prevent more serious complications and improve long-term health outcomes. However, thyroid disease diagnosis can be challenging due to its variable symptoms and limited diagnostic tests. By processing enormous amounts of data and seeing trends that may not be immediately evident to human doctors, Machine Learning (ML) algorithms may be capable of increasing the accuracy with which thyroid disease is diagnosed. This study seeks to discover the most recent ML-based and data-driven developments and strategies for diagnosing thyroid disease while considering the challenges associated with imbalanced data in thyroid disease predictions. A systematic literature review (SLR) strategy is used in this study to give a comprehensive overview of the existing literature on forecasting data on thyroid disease diagnosed using ML. This study includes 168 articles published between 2013 and 2022, gathered from high-quality journals and applied meta-analysis. The thyroid disease diagnoses (TDD) category, techniques, applications, and solutions were among the many elements considered and researched when reviewing the 41 articles of cited literature used in this research. According to our SLR, the current technique's actual application and efficacy are constrained by several outstanding issues associated with imbalance. In TDD, the technique of ML increases data-driven decision-making. In the Meta-analysis, 168 documents have been processed, and 41 documents on TDD are included for observation analysis. The limits of ML that are discussed in the discussion sections may guide the direction of future research. Regardless, this study predicts that ML-based thyroid disease detection with imbalanced data and other novel approaches may reveal numerous unrealised possibilities in the future
