The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has resulted in a global health crisis leading to widespread illness, death, and daily life disruptions. Having a vaccine for COVID-19 is crucial to controlling the spread of the virus which will help to end the pandemic and restore normalcy to society. Messenger RNA (mRNA) molecules vaccine has led the way as the swift vaccine candidate for COVID-19, but it faces key probable restrictions including spontaneous deterioration. To address mRNA degradation issues, Stanford University academics and the Eterna community sponsored a Kaggle competition.This study aims to build a deep learning (DL) model which will predict deterioration rates at each base of the mRNA molecule. A sequence DL model based on a bidirectional gated recurrent unit (GRU) is implemented. The model is applied to the Stanford COVID-19 mRNA vaccine dataset to predict the mRNA sequences deterioration by predicting five reactivity values for every base in the sequence, namely reactivity values, deterioration rates at high pH, at high temperature, at high pH with Magnesium, and at high temperature with Magnesium. The Stanford COVID-19 mRNA vaccine dataset is split into the training set, validation set, and test set. The bidirectional GRU model minimizes the mean column wise root mean squared error (MCRMSE) of deterioration rates at each base of the mRNA sequence molecule with a value of 0.32086 for the test set which outperformed the winning models with a margin of (0.02112). This study would help other researchers better understand how to forecast mRNA sequence molecule properties to develop a stable COVID-19 vaccine.
Abstract:
Typological analysis about the negation marker in different languages is one of the fields of research that has attracted much attention. In Persian language, this constituent has been analysed from different aspects. This study aimed to analyse different aspects of negation marker in the adjectives, the noun phrases and the verb phrases based on typological analysis. Many studies have been revealed that the negation in adjectives has shown lexically and morphologically. In the noun phrases, /hich/ has used as a negative marker necessarily marking the verb phrase as negative too. In the verb phrases, negation occurs morphologically by the addition of the prefix /n
... Show MoreCoronavirus is considered the first virus to sweep the world in the twenty-first century, it appeared by the end of 2019. It started in the Chinese city of Wuhan and began to spread in different regions around the world too quickly and uncontrollable due to the lack of medical examinations and their inefficiency. So, the process of detecting the disease needs an accurate and quickly detection techniques and tools. The X-Ray images are good and quick in diagnosing the disease, but an automatic and accurate diagnosis is needed. Therefore, this paper presents an automated methodology based on deep learning in diagnosing COVID-19. In this paper, the proposed system is using a convolutional neural network, which is considered one o
... Show MoreThe coronavirus disease 2019 (COVID-19) pandemic and the infection escalation around the globe encourage the implementation of the global protocol for standard care patients aiming to cease the infection spread. Evaluating the potency of these therapy courses has drawn particular attention in health practice. This observational study aimed to assess the efficacy of Remdesivir and Favipiravir drugs compared to the standard care patients in COVID-19 confirmed patients. One hundred twenty-seven patients showed the disease at different stages, and one hundred and fifty patients received only standard care as a control group were included in this study. Patients under the Remdesivir therapy protocol were (62.20%); meanwhile, there (30.71
... Show MoreCOVID-19 is a disease caused by a coronavirus spread globally, including in Iraq; infections have appeared on all Iraq lands in varying proportions. Iraq is among the higher infected world countries. Forty-six infections were simulated on 23 March 2020. Injuries on the eastern side of Baghdad city and to the right side of the Tigris River, which divides the city into two parts, are a natural barrier in quarantine and easily control the movement of people from both sides.
In this study, a model was considered a scientific and practical method by following the steps of identifying infected people using the best scientific approach for the spatial process to prevent the virus from spreading. Remote sensing techniques were
... Show MoreWhen images are customized to identify changes that have occurred using techniques such as spectral signature, which can be used to extract features, they can be of great value. In this paper, it was proposed to use the spectral signature to extract information from satellite images and then classify them into four categories. Here it is based on a set of data from the Kaggle satellite imagery website that represents different categories such as clouds, deserts, water, and green areas. After preprocessing these images, the data is transformed into a spectral signature using the Fast Fourier Transform (FFT) algorithm. Then the data of each image is reduced by selecting the top 20 features and transforming them from a two-dimensiona
... Show MoreThe present study investigates the implementation of machine learning models on crop data to predict crop yield in Rajasthan state, India. The key objective of the study is to identify which machine learning model performs are better to provide the most accurate predictions. For this purpose, two machine learning models (decision tree and random forest regression) were implemented, and gradient boosting regression was used as an optimization algorithm. The result clarifies that using gradient boosting regression can reduce the yield prediction mean square error to 6%. Additionally, for the present data set, random forest regression performed better than other models. We reported the machine learning model's performance using Mea
... Show MoreThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) or 2019 novel coronavirus (2019-nCoV) is quickly spreading to the rest of the world, from its origin in Wuhan, Hubei Province, China. And becoming a global pandemic that affects the world's most powerful countries. The goal of this review is to assist scientists, researchers, and others in responding to the current Coronavirus disease (covid-19) is a worldwide public health contingency state. This review discusses current evidence based on recently published studies which is related to the origin of the virus, epidemiology, transmission, diagnosis, treatment, and all studies in Iraq for the effect of covid-19 diseases, as well as provide a reference for future research
... Show MoreThis research aims to analyze and simulate biochemical real test data for uncovering the relationships among the tests, and how each of them impacts others. The data were acquired from Iraqi private biochemical laboratory. However, these data have many dimensions with a high rate of null values, and big patient numbers. Then, several experiments have been applied on these data beginning with unsupervised techniques such as hierarchical clustering, and k-means, but the results were not clear. Then the preprocessing step performed, to make the dataset analyzable by supervised techniques such as Linear Discriminant Analysis (LDA), Classification And Regression Tree (CART), Logistic Regression (LR), K-Nearest Neighbor (K-NN), Naïve Bays (NB
... Show MoreABSTRACT University college libraries are one of the most important information institutions for all researchers during their research and study life, they seeks to provide information sources such as; books, periodicals, theses, databases, Inquiry service and answering questions services in various disciplines to achieve its goals. In 2020, college libraries of all types stepped up to meet the needs of their users' as they responded to the impacts of COVID-19, also extended necessary lifelines to community members facing job losses, healthcare crises, and remote work and learning during an unprecedented and uncertain time. The research aim to identifying the services provided to the postgraduate students users at University of Baghdad coll
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