Infection with cryptosporidiosis endangers the lives of many people with immunodeficiency, especially HIV patients. Nitazoxanide is one of the main therapeutic drugs used to treat cryptosporidiosis. However, it is poorly soluble in water, which restricts its usefulness and efficacy in immunocompromised patients. Surfactants have an amphiphilic character which indicates their ability to improve the water solubility of the hydrophobic drugs. Our research concerns the synthesis of new cationic Gemini surfactants that have the ability to improve the solubility of the drug Nanazoxide. So, we synthesized cationic Gemini surfactants. N1,N1,N3,N3-tetramethyl-N1,N3-bis(2-octadecanamidoethyl)propane-1,3-diaminium bromide (CGSPS18) and 2,2‘-(ethane-1,2-diylbis(oxy))bis(N-(2-octadecanamidoethyl)-N,N-dimethyl-2-oxoethane-1-aminium) dichloride (CGSES18) and the detection of their chemical composition by spectroscopic methods, as well as studying the properties of their surfaces and their toxicity. Furthermore, the efficacy of nitazoxanide in infected mice was studied in conjunction with three different doses of surfactants. To assess the effect of nitazoxanide and surfactants, the infection was parasitologically counted before and after treatment, and the intestinal, liver, and lung tissues were also examined histopathologically. In this study, it was found that the combination of the drug nitazoxanide with surfactants, especially the compound (CGSPS18) at a concentration of 25% increased the efficacy and resulted in a percentage reduction of 90.8%. Histopathological examination revealed that the group treated with the drug nitazoxanide in combination with CGSPS18 showed the best results exhibiting an almost normal villous pattern. This study demonstrated an increase in the effectiveness of nitazoxanide when combined with surfactants, and this suggests a promising future for the use of surfactants as an adjunct to enhance the effectiveness of nitazoxanide for the treatment of cryptosporidiosis in immunocompromised patients, particularly HIV patients.
ان حـق التنميـة والتطـور مـن احلقـوق التـي طالبـت هبـا املجتمعـات الدوليـة كافـة السـيام بعـد احلــرب العامليــة الثانيــة، ولكــن العقوبــات االقتصاديــة التــي فرضــت عــى العــراق مل تراعــي حقــه يف التنميــة فبعــد ان كان العــراق يتجــه نحــو التقــدم والتطــور يف منطقــة الــرق االوســط عــاد إىل التدهـور والضعـف بسـبب فـرض العقوبـات االقتصاديـة عليـه مـن قبـل املجتمـع الـدويل ، ونظـرا المهي
... Show Moreبعد مرور عام واكثر على ظهور فيروس كورونا والعالم يواجه تسونامي تلك الجائحة التي تكاد تعصف بالوجود البشري برمته لذا اخذت البشرية على عاتقها مواصلة الجهود والابحاث للوصول الى علاج طبي يتم من خلاله مواجهة هذا الفيروس او التقليل من آثاره التي تهدد الحياة البشرية بالموت المباشر دون الاصابة، مما نتج عن تلك الجهود مجموعة من اللقاحات التي تبنتها الشركات العالمية المسؤولة الا ان الضرورة القصوى التي نتجت عنها تلك الل
... Show Moreيدرس هذا البحث مشكلة اعتماد الجمهور العراقي على الصحف، باعتبارها إحدى وسائل الإعلام التقليدية، في تكوين معلوماته ومعرفته العامة. وهي دراسة وصفية اعتمدت المنهج الوصفي المسحي الذي يصور الظروف أو الاتجاهات الحالية للظاهرة قيد الدراسة ويحاول تفسيرها. استخدم الباحث الاستبانة في المقام الأول كأداة بحث، حيث تم تصميمها وتوزيعها على عينة مكونة من 150 باحثا قصديا من قراء وقراء الصحف. وينتهي الباحث بالنتائج التالية: إ
... Show MoreAbstract
One of the major components in an automobile engine is the throttle valve part. It is used to keep up with emissions and fuel efficiency low. Design a control system to the throttle valve is newly common requirement trend in automotive technology. The non-smoothness nonlinearity in throttle valve model are due to the friction model and the nonlinear spring, the uncertainty in system parameters and non-satisfying the matching condition are the main obstacles when designing a throttle plate controller.
In this work, the theory of the Integral Sliding Mode Control (ISMC) is utilized to design a robust controller for the Electronic Throttle Valve (ETV) system. From the first in
... Show Moreيأخذ هذا النوع من الدراسات اهميته في مجال الكتابة التاريخية لما لها من اهمية في بناء التراث الفكري الحضاري للامة العربية الاسلامية.
The theme of the Abbasid Caliph and their children great interest in the knowledge and effective not only in the history of civilization but in the history of the humanity and the sublime values. Their interest and care for the scholar ulamaa and rendering help and encouragement by their caliphs were keen for science and knowledge because whatever the scholars have a status they cannot give help without and knowledge and the practice of their role in the interest and the care
يعد الصراعات الدولية ظاهرةقديمة قدم البشرية وعلى المستوى الدولي وغالبا ما تكون الدول الصغرى هي الساحة لتصفية الصرااعت بين الدول الكبرى كما هو الحال في سوريا مما يؤدي لعدوم وجود امن انساني فيها
Television white spaces (TVWSs) refer to the unused part of the spectrum under the very high frequency (VHF) and ultra-high frequency (UHF) bands. TVWS are frequencies under licenced primary users (PUs) that are not being used and are available for secondary users (SUs). There are several ways of implementing TVWS in communications, one of which is the use of TVWS database (TVWSDB). The primary purpose of TVWSDB is to protect PUs from interference with SUs. There are several geolocation databases available for this purpose. However, it is unclear if those databases have the prediction feature that gives TVWSDB the capability of decreasing the number of inquiries from SUs. With this in mind, the authors present a reinforcement learning-ba
... Show MoreEach language in the world has its special methods in using articles that connected with nouns. There are languages do not have articles and others their articles from one class, that is to say it do not have masculine and feminine such as our Arabic language. Also in some languages the nouns come after article.
The main aim in our research is to analyze the usage of these articles and its presence or not in the structure of sentence for the learners of Spanish language as a foreign language.
The usage of these articles in Spanish language forms one of the problems that face students in the grammar of Spanish language, at the same time it stands as a problem in translation becau
... Show MoreThe theme of the Abbasid Caliph and their children great interest in the knowledge and effective not only in the history of civilization but in the history of the humanity and the sublime values. Their interest and care for the scholar ulamaa and rendering help and encouragement by their caliphs were keen for science and knowledge because whatever the scholars have a status they cannot give help without and knowledge and the practice of their role in the interest and the care.