Numerous blood biomarkers are altered in COVID-19 patients; however, no early biochemical markers are currently being used in clinical practice to predict COVID-19 severity. COVID-19, the most recent pandemic, is caused by the SRS-CoV-2 coronavirus. The study was aimed to identify patient groups with a high and low risk of developing COVID-19 using a cluster analysis of several biomarkers. 137 women with confirmed SARS CoV-2 RNA testing were collected and analyzed for biochemical profiles. Two-dimensional automated hierarchy clustering of all biomarkers was applied, and patients were sorted into classes. Biochemistry marker variations (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) have split COVID-19 patients into two groups(severe cases and non-severe cases groups). Ferritin, lactate dehydrogenase LDH, D-dimer and CRP were markedly increased in COVID-19 patients in the first group (severe cases). Our findings imply that early measured levels of (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) are linked to a decreased probability of COVID-19 severity. Elevated levels of this biomarker may predict COVID severity development.
Numerous integral and local electron density’s topological parameters of significant metal-metal and metal-ligand bonding interactions in a trinuclear tetrahydrido cluster [(Cp* Ir) (Cp Ru)2 (μ3-H) (μ-H)3]1 (Cp = η5 -C5Me5), (Cp* = η5 -C5Me4Et) were calculated and interpreted by using the quantum theory of atoms in molecules (QTAIM). The properties of bond critical points such as the delocalization indices δ (A, B), the electron density ρ(r), the local kinetic energy density G(r), the Laplacian of the electron density ∇2ρ(r), the local energy density
... Show MoreTo determine the seroprevalence of hepatitis B markers in chronic hepatitis B patients, 75 patients with chronic hepatitis B virus of ages (8-70) years have been investigated and compared with 50 apparently healthy individuals. All the studied groups were carried out to measure (HBsAg), (HBsAb), (HBeAg), (HBeAb), and (Total HBcAb) by Enzyme linked immunosorbent assay (ELISA) technique. The percentage distribution of HBsAg was (86.67%) and HBsAb was (1.33%) in sera of CHB patients and there were a highly significant differences (P<0.01) when compared between studied groups, while, the percentage distribution of HBeAg was (22.67%) in sera of CHB patients and the significant represent the difference in distribution of HBeAg as infection but no
... Show MoreRandom Amplification of Polymorphic DNA (RAPD) analysis was used in this study to direct the attention toward increasing the efficiency of early diagnosis of breast cancer in clinical laboratories at Iraq using recent PCR-dependent protocols and investigate DNA polymorphisms in addition to the detection of genomic markers. Blood samples were collected from 12 diagnosed females with breast cancer (malignant) patients, 12 females with breast benign tumor and 12 controls (normal females). DNA was extracted and RAPD-PCR was performed. The results showed unique profiles of amplified DNA fragments produced in genomic DNA of breast tumors by an arbitrary primers of A8, A11, A12, A13, A15 and A18. Out of the 6 primers used, 1 primer produced mon
... Show MoreHypothyroidism is a condition in which thyroid hormones levels decreased in the blood. These hormones are necessary for energy production and body viability. In many occasions this condition is accompanied or followed by different metabolic disorders. The current study is conducted in the "Specialized center for endocrinology and diabetes" and carried on 70 hypothyroid patients and 60 randomly chosen individuals with normal thyroid function .Both groups were submitted to laboratory tests to evaluate thyroid function (T3,T4.TSH). The study involved evaluation of the relationship between hypothyroidism and insulin resistance (IR) . Health problem related to many diseases , became common lately. Insulin resistance diagnosed through
... Show MoreBackground: Astrocytic tumors are the most common primary tumors of the central nervous system. Several grading systems are used to grade astrocytomas. The most widely used system is the World Health Organization (WHO) classification (1979, 1993, 2000, and 2007) that grades astrocytomas (I-IV) based on cytological atypia, mitotic activity, vascular proliferation, and necrosis: pilocytic astrocytoma (grade I), diffuse astrocytoma (grade II), anaplastic astrocytoma (grade III), and glioblastoma (grade IV).
Objectives: The aim of this study is to evaluate p53 over expression , Ki-67 expression in astrocytomas and Correlate these two markers with histologic grade of astrocytomas.
Methods: Formalin fixed, paraff
Background: The present article is concerned within the scope of Forensic Medicine, specifically Forensic Genetics. The case was taken care of in the Genetic-Molecular Laboratory of the Odessa Regional Bureau of Forensic-Medical Examinations, in Ukraine, during January and February of 2014.
Objectives: The aim of our work was to identify an unknown person, using the techniques: Y-chromosome markers and mitochondrial DNA typing.
Materials and methods: The materials available for our procedure were: pieces of tissue in paraffin blocks, saved from the corpse of the unknown person; blood from a living male subject, who claimed to be the grandfather, and from two females, allegedly the sisters. From all of them we extracted nuclear DNA
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown etiology, though genetic and environmental factors appear to play a role in its pathogenesis. In particular, infectious processes are linked to the onset and exacerbation of SLE. The aim of the current study was to understand the relationship between some biochemical factors in SLE patients. 105 blood samples from both genders were collected. ELISA technique was used for detecting specific procalcitonin, vitamin D and calcium. The results of this study showed that SLE patients recorded the lowest percentages of calcium (7.36 ± 0.10 mg/dl) than control (11.97 ± 2.12 mg/dl), and vitamin D (7.79 ± 0.58 pg/ml) than control (22.10 ± 4.8
... Show MoreAbstract\
The value chain analysis is main tools to achieve effective and efficient cost management; it requires a depth and comprehensive understanding for all internal and external activities associated with creating value. Supply chain as apart of value chain, that means managing it in active and efficient can achieve great results when adopting a comprehensive and integrated performance for these two chains activities. The research aims to identify possible ways to integrate the performance of value and supply chains of the sample" Kufa-cement plant" and determine the effect of this integration in enhancing customer value. The research arrival that logical and integrated analysis of value and supply chains helps
... Show MoreThe ground state densities of unstable neutron-rich 11Li and 12Be exotic nuclei are studied in the framework of the binary cluster model (BCM). The internal densities of the clusters are described by the single particle harmonic oscillator wave functions. The long tail performance is clearly noticed in the calculated neutron and matter density distributions of these nuclei. The structures of the two valence neutrons in 11Li and 12Be are found to be mixed configurations with dominant (1p1/2)2. Elastic electron scattering proton form factors for 11Li and 12Be are studied using the plane wave Born approximation (PWBA). It is found that the major difference between the calculated form factors of unstable nuclei [11Li, 12Be] and those of stab
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