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bsj-7402
Synthesis, Anticancer and Antibacterial Activity of Mannose-based bis-1,2,3-Triazole Derivatives
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       In the current work, aromatic amines and alkyl halides have been converted to the corresponding azides 2a‒d and 4a-d by the reaction with sodium nitrite and sodium azide respectively for amines and sodium azide for halides. Then, dipropargyl ether derivative of D-mannose 8 has been synthesized from diacetone mannose that has been obtained by the treatment of D-mannose (5) with dry acetone in the presence of sulfuric acid. Then, aldol condensation has been used to prepare diol 7 from the mannose diacetonide 6. The reaction of compound 7 with propargyl bromide in alkaline media has been afforded dipropargyl derivative 8. In a parallel step, both dialkyne with aromatic and aliphatic azide have been coupled to produce 1,2,3-triazole derivatives 9ad in the presence of Cu(I) salts. All synthesized compounds have been characterized by 1D and 2D NMR spectra alongside with HRMS data. The antibacterial activity against both gram-positive and gram-negative has been tested. Moreover, the anticancer activity has also been evaluated against AMJ13 cell line.

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Publication Date
Sat Jun 08 2024
Journal Name
Plant Science Today
Antibacterial and antioxidant activities of Alcea kurdica flower, leaf and root aqueous and organic extracts
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Global concerns are rising due to complications associated with the use of chemical agents and antibiotic resistance. Consequently, research focus has shifted towards the quest for effective agents of biological origin. The aim of the present study was to assess the antioxidant and antimicrobial potentials of aqueous and organic extracts derived from various parts of Alcea kurdica. Different parts of A. kurdica were obtained and prepared into leaf, flower and root powders. The powders were extracted with aqueous and organic solvents. The antimicrobial activity of these extracts was assessed against bacterial pathogens using the agar well-diffusion assay. Additionally, the antioxidant effects of the extracts were evaluated using the

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Publication Date
Tue Jun 11 2002
Journal Name
Iraqi Journal Of Laser
Investigating the Effects of Carbon Dioxide Laser Fluence on Oral Soft Tissue
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This study investigates the surgical and thermal effects on oral soft tissues produced by CO2 laser emitting at 10.6 micrometers with three different fluences 490.79, 1226.99 and 1840.4 J/cm2. These effects are specifically; incision depth, incision width and the tissue damage width and depth. The results showed that increasing the fluence and /or the number of beam passes increase the average depths of ablation. Moreover, increasing the fluence and the number of beam passes increase the adjacent tissue damage in width and depth. Surgeons using CO2 laser should avoid multiple pulses of the laser beam over the same area, to avoid unintentional tissue damage.

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Publication Date
Thu Feb 26 2026
Journal Name
Int. J. Corros. Scale Inhib.
DFT and experimental investigation of a novel 1,2,4-triazole derivative as a corrosion inhibitor for carbon steel A106 G/B in HCl solution
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This work introduces a newly synthesized triazole derivative, 5-([(2-furanyl)methyl]-thiomethyl)-4-(naphtha-2-yl)-3-hydroxyl-4H-1,2,4-triazole (FTNT), as an effective corrosion inhibitor for carbon steel A106 G/B in 0.1 M HCl solution. The structure of the novel derivative was confirmed by FTIR, 1 H NMR, and 13 C NMR spectra. Potentiodynamic polarization measurements reveal that FTNT markedly suppresses corrosion, with inhibition efficiency reaching 81.6% at 600 ppm. Thermodynamic analysis indicates spontaneous, physisorption/chemisorption-augmented adsorption of FTNT on the steel surface, best described by the Freundlich isotherm. Atomic force microscopy (AFM) surface examination demonstrated that a protective FTNT coating precipitated on

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Publication Date
Fri Jun 16 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Autophagy or Apoptosis: Anticancer Molecular Mechanism of Epigallocatechin Gallate with Natural Polyphenol Effect on HepG2 Cells Viability
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Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied.  Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptos

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Publication Date
Tue Jun 01 2010
Journal Name
Journal Of Economics And Administrative Sciences
مقارنة بعض طرائق التعويض الأحادي للبيانات المفقودة لدالة الكثافة الاحتمالية للتوزيع الطبيعي ثنائي المتغيرات
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In this paper we suggest new method to estimate the missing data  in bivariate normal distribution and compare it with Single Imputation  method (Unconditional mean and Conditional mean) by using simulation. 

 

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Publication Date
Sun Dec 01 2013
Journal Name
Bmc Complementary And Alternative Medicine
Synergy of antibacterial and antioxidant activities from crude extracts and peptides of selected plant mixture
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Abstract<sec><title>Background

A plant mixture containing indigenous Australian plants was examined for synergistic antimicrobial activity using selected test microorganisms. This study aims to investigate antibacterial activities, antioxidant potential and the content of phenolic compounds in aqueous, ethanolic and peptide extracts of plant mixture.

Methods

Well diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays were used to test antibacterial activity against four pathogenic bacteria namelyStaphylococcus aureus, Escherichia coli, Bacil

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Publication Date
Sat Aug 15 2015
Journal Name
Chemistry And Materials Research
Synthesis and Characterization of 3, 5-Dimethyl-2-(4-nitrophenyl azo)-Phenol Complexes with Co (II) and Ni (II) and Study Its Effect on the Activity of Ach Enzyme (invitro)
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Publication Date
Sun Apr 01 2012
Journal Name
Journal Of Educational And Psychological Researches
اثر استعمال انموذج ديك و كاري في تحصيل طالبات الأول المتوسط في مادة جغرافية
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Occupies an important geographical position, and instructional material is distinctive among the various course materials, as covered in the study of human and surrounding environment, and interaction happening between them, and the problems that arose as a result and a lot of reliable in achieving educational purposes. Through the monotony and tradition in the methods used in our schools in the teaching of geography, which prevails in teaching nature conservation and indoctrination with poor educational qualification as a teacher geography, and the fact that this article need to be effective methods for teaching, such as the use of teaching models modern-dependent student at the center of the process education, and this is confirmed by

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Publication Date
Sat Dec 31 2022
Journal Name
مجلة علوم التربية الرياضية
بعض القدرات البدنية الخاصة و علاقتها بالتحرك الدفاعي والانطلاق للهجوم السريع الفردي بكرة اليد
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يهدف البحث عن الاساليب والعوامل التي ترفع من قدرات اللاعبين البدنية و المهارية للتواصل مع التطور المطلوب حيث وجد ان هناك حاجة ملحة لتطوير الهجوم السريع الفردي وذلك لضعف و تذبذب الاداء الفني بكرة اليد تحتاج في المباراة الخاصة السرعة الانتقالية التي ترتكز عليها صفة السرعة دون الهبوط بالمستوى المطلوب لتحقيق ثمرة جهد هذا الاداء بأداء تصويبه في مرمى الفريق الخصم لمحصلة هذا الاداء المميز يتطلب ان يكون كل لاعب من

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Publication Date
Tue Mar 08 2016
Journal Name
مجلة كلية الاداب
القوى الاقليمية المؤثرة بامن و استقرار اليمن المملكة العربية السعودية انموذجا للمدة 1990-2015
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تشكل المملكة العربية السعودية دورا فاعلا في استقرار اليمكن