Rheumatoid arthritis (RA), is an autoimmune, and inflammatory disease that is closely related to the destruction of cartilage and bone. DC-SIGN are important types of C-type lectin receptors (CLRs), expressed on dendritic cells and macrophages, and have a central role in regulating innate and adaptive immunity, function as pattern recognition receptors, and as cell adhesion molecules. Recent evidence has demonstrated that DC-SIGN is involved in the pathophysiological of chronic inflammation, so DC-SIGN has been linked to several autoimmune and may play an essential indicator in the pathogenesis and progression of RA. Therefore, the purpose of this study is to determine the serum level of DC-SIGN in RA patients, as well as the level of DC-SIGN based on demographic characteristics. Fifty Iraqi RA patients were enrolled in the study, and a control sample of 38 healthy individuals (ascertain by laboratory and clinical tests) were included and matched by gender, age, and ethnicity with the patients. The DC-SIGN concentration was calculated in the patients’ serum and compared to control using the ELISA assay and the results revealed significantly increased serum level of DC-SIGN (12.047 ± 1.114 vs. 6.863 ± 0.806 ng/ml) was recorded in RA patients compared to controls. When correlating results, it was shown that the concentration of DC-SIGN in the serum did not record a significant difference between gender and age, as well as the blood groups. To determine the impact of the therapeutic status in RA patients on the DC-SIGN level, it was found that the concentration of DC-SIGN level was higher in untreated patients compared to treated patients. Regarding viral infection, when an investigation was conducted in RA patients infected with SARS-CoV-2, the serum level of DC-SIGN in RA patients with COVID-19 showed no change in concentrations compared to uninfected RA patients.
The study aims to identify the students’ attitudes toward recent techniques’ use in teaching; using power point software and data show to facilitate teaching approaches as well as following the approach of lecture in giving subjects, do these techniques facilitate, increase, and tackle the difficulties of subjects, do these attitudes positive or negative?, and to what extent these techniques raise up students’ motivation.
The internationalization of the Libyan crisis and its accompanying militarization of the conflict have played a vital role in hindering to reach a comprehensive political settlement solution in Libya. The increasing international greediness in the Libyan energy resources and the geopolitical importance of the Libyan State led to the involvement of many international and regional powers in this crisis and transformed the Libyan crisis into “proxy war”. Moreover, the Turkish direct military intervention in the Libyan crisis is considered as one of the main constraints facing the international and regional efforts to settle the Libyan crisis as a result of the Turkish insistence on its military existence in Libya to preserve i
... Show MoreIf the syntactic structure is a reflection of what is in the mind of the creator of synergies
نالت الحياة الادبية في مملكة غرناطة الاندلسية حظاً كبيراً
تتسارع التحولات السياسية في العصر الحديث، وتتزايد التحديات التي تواجه المجتمعات، حيث يظهر التطرف كظاهرة تهدد أمن الدول واستقرارها، وتعد الإصلاحات السياسية خطوة حيوية نحو تحقيق تنمية مستدامة وتحقيق التوازن في المجتمعات. أذ يهدف هذا البحث إلى استكشاف وتحليل دور الأصلاح السياسي كآلية فعالة في مكافحة ظاهرة التطرف. وطالما أن الدول في المنطقة العربية تعاني من التسلط والأستبداد وغياب دور المؤسسات السياسية الفعل
... Show Moreإن أهميـة بحثنـا تتضـح مـن خـلال التطـرق إلى دراسـة المـذهب العسـكري في حقبـة الاتحـاد السـوفيتي السـابق وإبـراز الجوانـب الرئيسـة المتعلقـة بفلسـفة المـذهب العسـكري السـوفيتي ومضـامينه الاستراتيجية مــن جانــب، وفلســفة المــذهب العســكري الروســي لمرحلــة مــا بعــد الحــرب البــاردة والتغـيرات المهمـة الـتي طـرأت عليـه، ممـا أفـرز لنـا بطبيعـة الحـال مضـامين مـذهب عسـكري روسـي جديــد قــد يتقــا
... Show MoreThe history of the arts is closely connected with the history of humankind, since it is impossible to separate our scientific and artistic advances’. Therefore, the current research focuses on the close bond between art and other disciplines. The connection of the arts to the sciences is unequivocal and undisputed; the contributions of artists to the various scientific domains are clear. If one scrutinises the ability of artists to participate in building societies, one will find that the arts have penetrated deeply into a range of products and inventions, starting with the pencil and ending with the missile. The artist’s contributions play a part in the minutest of details across all fields of industry: production, craftsmanship, me
... Show MoreThat is feared we frequent urgent calls from Islamic scholars and leaders of the Muslim faithful to their religion and nation to a culturally، economically، politically and militarily Muslim communities، in response to the call of the divine stones in the sit-rope of God and taking the greatest causes of strength and stamina، pride and empowerment
قسّم الباحث الشخصيات في هذ ا البحث إلى أقسام: اإيجابية والسلبية
والسطحية...ثم تطرقا إل خصوصياتها النفسيّة وبينا مقصود الكاتبة، وتطرّقا إلی الغزو
الثقافي الغربي ،