Preferred Language
Articles
/
bsj-6431
Predictive Significance of Interleukins 17A and 33 in Risk of Relapsing–Remitting Multiple Sclerosis
...Show More Authors

Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.

Scopus Clarivate Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Sun Jan 01 2006
Journal Name
Journal Of Educational And Psychological Researches
اثر لعبة كرة القلب في خفض غضب أطفال الروضة
...Show More Authors

مشكلة البحث واهميته :

            يعد الغضب من المظاهر الانفعالية الشائعة في مرحلة الطفولة المبكرة وذلك بسبب كثرة المواقف المثيرة لغضب الطفل في هذه المرحلة ، كما ان الطفل في هذه المرحلة سرعان ما يكتفي في كثير من الاحيان بان غضبه وبكائه طريقة سهلة للوصول الى ما يريد . ويعد المختصون في هذا المجال ، بان نوبات غضب الاطفال ، هي شيء عام طبيعي عند جميع الاطفال ، لكن عندما تكون نوبات عنيفة

... Show More
View Publication Preview PDF
Publication Date
Wed May 05 2021
Journal Name
Arab Science Heritage Journal
تربية الشباب في التراث الاسلامي وانعكاساتها على الواقع المعاصر
...Show More Authors

Islam paid great attention to the youth, and took care of them because they
are the strength and movement, which is the preferrence stage in human life,
and they are the ones who

View Publication Preview PDF
Crossref
Publication Date
Wed Jul 16 2025
Journal Name
Political Studies And Strategic
تطور تكنولوجيا الطائرات بدون طيار في ظل الحروب المستقبلية
...Show More Authors

The development of drone technology in state of future warsDrones have recently imposed themselves as an effective multi-tasking weapon. States and armed groups have sought to possess them, due to their importance in delivering painful blows to the enemy at a low cost. This technology has played a prominent and varied role in many wars and stimulated countries to manufacture or obtain it

View Publication
Publication Date
Sun Nov 04 2018
Journal Name
Arab Science Heritage Journal
الشيخ الشيخ علي خان زنكنة واصلاحاته الداخلية في ايران
...Show More Authors

 

                                                                                                          Shakh Ali Khan Zangna was a minister of a big state in terms of its wide lan

... Show More
View Publication Preview PDF
Publication Date
Wed Sep 01 2010
Journal Name
Journal Of Economics And Administrative Sciences
مكافحة ظاهرة الفساد في إطار تكامل المحتويين الإداري والاستراتيجي
...Show More Authors

ينقسم الاتجاه الأساسي الذي يجري مناقشته في هذه الورقة إلى مستويين: الأول يركز على تحديد مضمون العلاقة بين الشفافية والفساد، فضلا عن توضيح الدور الذي يمكن أن تؤديه أخلاقيات الأعمال، لتثار التساؤلات هي: هل أن الشفافية والفساد متغيرين مرتبطين معا؟ وهل تؤثر الشفافية في الفساد؟ وهل أن وجود الشفافية كفيل بإزاحة الفساد، أم نحتاج إلى شيء أخر يدعم عملية الشفافية؟ وإذا تم التحدث عن الشفافية كمصطلح بدون وجود مما

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sun Jul 07 2013
Journal Name
Journal Of Educational And Psychological Researches
العولمة الثقافية في القيم التربوية لطالبات قسم رياض الاطفال
...Show More Authors

Seemed reflections of cultural globalization are clear on the values of communities those values that preserve each community privacy, so that became members of these communities lack the ability to distinguish clearly between what is right and what is wrong and adoption of ideas and values imported from abroad, regardless of whether positive or negative. The aim of the research was to: - 1 - Detection of cultural globalization in the educational values for students kindergarten section. 2 - To identify the most prominent educational values (social, scientific, aesthetic, moral and spiritual) globalized culture. The current Aqtsralbges on: - Department of kindergarten students to study in the morning College for Girls, Baghdad University

... Show More
View Publication Preview PDF
Publication Date
Sun Dec 02 2018
Journal Name
Arab Science Heritage Journal
القبائل الآمورية ودورها التأريخي في بلاد الرافدين وبلاد الشام
...Show More Authors

The research titles “Ammorrite tribes and their historical role in Mesopotamia and Levant” deals with tribe structure, nomination, political and cultural roles of these tribes in Mesopotamia and Levant, as it terminate Sumerian presence in Iraq and changed historical course and contributed in changing population landmarks and started new bright era, in addition to admitting new beliefs, gods and laws, beside ruling principles which became tribal, i.e., dynasties instead of Sumerian rulings based on religion belief.

View Publication Preview PDF
Publication Date
Thu Dec 13 2018
Journal Name
Arab Science Heritage Journal
صك صك الرزق في القرن الأول الهجري(البطاقة التموينية)
...Show More Authors

 The government gave the muslims additional things to the sum of money ,it was al rizq which was given to the mujahidin .

   Those who distributed the ata where called al urafa ,they were from the best biography people

View Publication
Publication Date
Sun Mar 01 2009
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
مسؤولية مراقب الحسابات في تقويم مخاطر المشروعات الصغيرة والمتوسطة
...Show More Authors

There are many characters which belong to small & medium projects, this is not relate to their size only but also to its quality charchcters & the quantities indicators.

There is a focus in the ownership, management, Resources beside the limited internal control system.

 the auditor must put his program according to the project’s circumstance, so auditing the small projects differs than other projects which maybe is less complex and done by limited persons

This research aims to show the responsibility of certified public accountant in evaluation the risks of the small & medium projects through depending the audit- based risk program which develop the useful information.

View Publication Preview PDF
Publication Date
Sun Dec 02 2007
Journal Name
Political Sciences Journal
التطورات السياسية في افريقيا جنوب الصحراء بعد الحرب الباردة
...Show More Authors

التطورات السياسية في افريقيا جنوب الصحراء بعد الحرب الباردة

View Publication Preview PDF
Crossref