This study aims to investigate the possible role of circulating microRNA-142-3p (miR-142-3p) in the
development of graves disease (GD) and its association with the antibody directed against thyroid
stimulating hormone receptor (TSHR-Ab) production in patients with GD. Forty patients with positive
TSHR-Ab enrolled in this study were divided ,based on treatment, into (22 untreated (newly diagnosed) and
18 treated patients) and based on family history (30 with positive family history and 10 with negative family
history). In addition to forty healthy subjects with sex and age matching as a control group. The expression
level of circulating miR-142-3p was determined by two steps reverse transcription polymerase chain reaction
(RT-PCR) technique. Results show that there is a significant elevation (p < 0.01) in the expression of miR-
142-3p in the serum of both treated and untreated patients compared with controls and in patients with
positive family history compared with negative family history. While its expression is non-significantly
lower (P > 0.05) in the serum of treated patients compared with untreated ones. It has been found that miR-
142-3p expression was positively correlated with levels of TSHR-Ab, FT3, and FT4. In addition, the miR-
142-3p expression has a good diagnostic accuracy with sensitivity (82%) and specificity (80%). In
conclusion, the differential expression of miR-142-3p between patients and healthy controls appears as a
potential biomarker for diagnosis of GD and the positive correlation of miR-142-3p with TSHR-Ab
suggesting the contribution of this miRNA in the development of GD.
يتداخل الأمن مع التنمية تداخلاً بناء وتداخلاً هداماً؛ فالأمن والتنمية مطلبان أساسيان متلازمان في علاقة جدلية تحكم أي علاقة استراتيجية للأمن القومي في أية دولة، ولا يمكن الحديث عن استراتيجية للأمن القومي دونما إرساء دعائم التنمية الاقتصادية والاجتماعية؛ باعتبارها صمام أمان وضمان استراتيجي للعملية الأمنية في بعدها الشامل ، كما إن غياب أو ضعف البنية الأمنية ينعكس بشكل مباشر على التنمية ويهدد بنسف أية مقاربة
... Show MoreThe importance of Public Relations activity has increased during the last half of the last century as a specialized and modern administrative function in most institutions. It has, moreover, become an integral part of activities of those institutions of various types, due to its pivotal role in building its reputation and drawing a good mental image among its audiences, as well as its influential and basic role in maintaining communication and the communication between its members at its various levels and their job tasks to ensure the greatest amount of understanding and to enhance trust between them. This is why public relations activity has become indispensable in all institutions, and without it, it is difficult to achieve any coordi
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... Show MoreBackground In rheumatoid arthritis, your immune system attacks the tissue lining the joints on both sides of your body. Other parts of the body may also be affected. Unsure of the exact cause. Two separate genes termed IL12A (p35) and IL12 encode the heterodimeric cytokine known as IL12 (p40). Several different hematopoietic cell types can have several different hematopoietic cell types that can generate antigen-presenting cells (APCs), including DCs and macrophages. Objectives This study aimed to investigate if the interleukin IL-12B gene's common polymorphisms in an Iraqi population were associated with RA. Material and methods Blood samples were taken from 70 Iraqi patients with RA illnesses and 30 Iraqi controls during the periods from
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... Show MoreIn the present research synthesis and study of biological activity a series of new polymers modified of chitosan with compounds containing azo group. Beginning diazonium salt produced from 3,3'-dimethyl-[1,1'-biphenyl]-4,4'-diamine reacted with concentrated HCl acid and sodium nitrite. The coupling reaction between diazonium salt with substituted aromatic aldehyde to produce Azo derivatives )1-6(. Azo Schiff bases Chitosan )7-12( were synthesized by condensation of Chitosan with Azo derivatives )1-6( in ethanol with some drops of glacial acetic acid. The structural modifications of Chitosan ring (linked to a bioactive azo moiety) were expected to give new derivatives )7-12( with a diverse range of biological functions. These compounds' st
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