Synthesis of 2-mercaptobenzothiazole (A₁) is performed from the reaction of  o-aminothiophenol and carbon disulfide CS₂ in ethanol under basic condition. Compound (A₁)  is reacted with chloro acetyl chloride to give compound (A₂). Hydrazide acid compound (A₃) is obtained from the reaction of compound (A₂) with  hydrazine hydrate in ethanol under reflux in the presence of glacial acetic acid .The reaction of hydrazide acid compound (A₃) with ethyl acetoacetate gives pyrazole compound (A₄). The new hydrazone  compound (A₅) was prepared from the reaction of compound (A₃) with  benzaldehyde. Reaction of compound (A₃) with  thiourea  dissolved in ethanol  gave  2-amino thiazole  compounds(A₆) which was used the reaction with 4–N,N-dimethyl benzaldehyde to yield  compound hydrazone (A₇).While, the reaction of compound (A₂) with  urea  in the presence of ethanol  gave 2-amino oxazole  compounds (A₈) which was used in the reaction with 3-hydroxy – 4 -methoxy benzaldehyde to yield hydrazone (A₉). The structures of the prepared compounds were established by spectral (¹H-NMR,Elemental analysis (C.H.N- ),and  FT-IR. In addition to systematic characterization of some active functional groups in these compounds, antibacterial activity (Esheriechia coli,  Bacillus subtilis ) for some of the synthesized compounds were evaluated against two types of fugal (Candida albicans ) , the synthesized compounds.