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Physiological and Hormonal Effects of Titanium Dioxide Nanoparticles on Thyroid and Kidney Functions

           Titanium dioxide nanoparticles (TiO2 NPs) are generally used in different types of applications such as the industry of plastics, paper industry, paints, toothpaste, cosmetics, sunscreens, and in various lifestyles, because of the vast range of applications and our daily exposure to these nanoparticles and a lack of information on animal and human health this study was designed to reveal dose and time-dependent effects of TiO2-NPs on the thyroid gland and kidney functions in male rats.

For this study 54, Sprague-Dawley albino adult male rats were classified into three main groups each of 18 rats treated for a particular duration (1,2, and 4) weeks respectively. Each group was subdivided into three subgroups each of six rats treated as follows; group (1) serve as normal control, group (2, and 3) intra-peritoneal treated with TiO2NPs (50,200) mg/kg respectively, rats are dissected at the end of each experiment and the weights of thyroid and kidney is measured. The result showed a highly significant decrease (p<0.01) in the thyroid gland and a highly significant increase (p<0.01) in kidney weights and TSH, blood urea, creatinine, and total protein, while a highly significant decrease (p<0.01) inT3 and T4 in all different doses (50,200) mg/kg at durations 1, 2 and 4 weeks. The outcomes of the present study illustrate a significant decrease in serum levels of T4 and T3 with exposure to TiO2 NPS which disrupts thyroid function, while TiO2 NPS raises the level of urea, total protein, and creatinine. This could be related to the high dose of TiO2-NPs and duration of the study, which caused degeneration and necrosis of kidney cells and damage to peritubules that led to the prevention of secretion which raised urea levels in the blood, also led to high levels of creatinine and total protein in serum because of the imbalance that occurred in the kidney functions.

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Publication Date
Wed Apr 15 2020
Journal Name
Journal Of The Faculty Of Medicine Baghdad
collision tumor of thyroid gland a case report

collision tumor is the presence of two histopathologically distinct tumors in the same anatomical site.  It is a rare pathology of the thyroid gland that makes diagnosis and treatment challenging.  This is a case report of a collision tumor of the thyroid gland.

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Publication Date
Wed Jan 02 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Physiological Changes In Spirometric Parameters During Pregnancy In Iraqi Women

Background: The events in pregnancy elicit one of the best examples of selective anatomical, physiological and biochemical adaptations, with profound changes in respiratory physiology. The changes in respiratory  physiology are due to increased  size of the fetus with advance  gestation which constitutes a mechanical impediment to normal process of ventilation.

.Patients and methods: This study started from the 1st of Nov.  2009 till the 30th of Oct. 2010. pregnant women aged (16-44 years) of different weight, height and different conception from 1st, 2nd, 3rd trimester and post term were included. Spirometry was performed in Baghdad teaching hospital( pulmonary fun

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Publication Date
Fri Jan 13 2023
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Kidney functions and electrolyte disturbance among Iraqi patients with bladder cancer

Background: Bladder cancer is among the most prevalent cancers worldwide, with 549,393 new cases reported in 2018. Approximately 3% of all new cancer diagnoses and 2.1% of all cancer deaths are due to urinary bladder cancer.

Objectives: This study aims to explore the efficiency of renal system functions as indicated by renal function tests and electrolyte levels among bladder cancer patients.

Methods: All patients in this case-control study were recruited from Ghazi Al-Hariri Hospital for surgical specialties in Baghdad during the period from December 2021 to June 2022. A total of 100 individuals were enrolled in this study and divided into two groups.

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Publication Date
Sun Jun 20 2021
Journal Name
Baghdad Science Journal
Hypothyroidism and Leptin in Iraqi Patients with Chronic Kidney Disease

The present study aims at assessing the effects of chronic kidney disease (CKD) on thyroid hormone and leptin by evaluating the level of: leptin hormone along with thyroid hormone in CKD patients. The study has been conducted on  70 subjects, 50 patients with an age range between 20-50 years (25  males and 25 females) who were diagnosed to have CKD stage-5, and 20 normal controls whose ages ranged between 20-48 years (10  males and 10 females), who attended  the Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April  2018  to July  2018. The study showed a highly significant (P<0.01) increase in TSH level in CKD patients in comparison with controls. While T3 and T4 levels observed highly significant decrea

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Publication Date
Sun Dec 30 2018
Journal Name
Journal Of Engineering
Synthesis and Characterization of Titanium Dioxide Nanoparticles under Different pH Conditions

Ethanol as a solvent, a precursor of titanium isopropoxide and a stabilizer of either hydrochloric acid or ammonium hydroxide was used to prepare a titanium dioxide aqueous solution. The aqueous solutions with different values of pH and the morphology of the resultant reaction of the nanoparticles of titanium dioxide were investigated. The X-ray diffraction showed that at low temperatures and with acidic solutions, rutile structures are more favorable to grow on titanium dioxide synthesized, while at low and average temperatures and with base solutions, anatase phase is more pronounced. The crystalline form and the re-confirmation of the crystallite size growth were observed by the scanning electron microscopy. The atomi

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Publication Date
Sun Oct 01 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Pre-operative serum TSH level estimation for predicting malignant nodular thyroid disease

Background: the aim of this study was to assess the value of serum thyroid–stimulating hormone (TSH) levels in predicting malignancy in patients with nodular thyroid disease (NTD). Objective: The aim was to examine the relationship between preoperative TSH and differentiated thyroid cancer (DTC).
Patients and Method: all patients with NTD who were admitted in the first surgical unit of Baghdad teaching hospital and assessed for preoperative TSH level before subjecting them for thyroidectomy from first of April 2014 to 31 of January 2016, were included in the study. A preoperative database sheets including Age, gender, nodule size, and pathology were evaluated. Logistic regression analysis was used t

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Publication Date
Sun Nov 08 2020
Journal Name
Journal Of The Faculty Of Medicine Baghdad
the The Role of Ultrasound in the Diagnosis of Malignant Thyroid Nodules

Background: Thyroid nodules are very common in clinical practice. Although most of thyroid nodules are benign, it is crucial to checkout which nodules are more likely to be malignant. Ultrasound is a major diagnostic tool for screening and evaluating thyroid diseases because it is safe, non-invasive, non-radioactive and effective.
Objective: The aim is to identify the role of ultrasound in assessing thyroid nodules and to review various ultrasound criteria predicting malignancy.
Patients and methods: A case series study conducted during the period from January 2015 to February 2016 at the First Surgical Unit, Department of Surgery, Baghdad Teaching Hospital by a team of surgeons. One hundred eighty Patients who underwent surgical i

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Publication Date
Mon Dec 20 2021
Journal Name
Baghdad Science Journal
Temperature Stress on Physiological and Morphological Traits in Rhizophora apiculata

Global warming has had considerable effects on vital ecosystems, which has also been caused by increased temperatures and CO2 that follow changes in different abiotic factors, which poses threats to mangrove forests environment. This research was conducted to examine the physiological and morphological characteristics of the Rhizophora apiculata mangrove regarding higher air temperature for the variety of tree species that respond to climate change. Seedlings were cultivated for three months in regulated growth chambers with three varying temperatures of 38°C, 21°C under CO2 at 450 ppm, and ambient CO2 concentration i.e., 450 ± 20 ppm under average temperature at 28°C as the control condition

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Publication Date
Fri Dec 12 2003
Journal Name
Iraqi Journal Of Laser
Carbon Dioxide Laser Treatment of Viral Warts: A New Approach

Verrucae vulgares are commonly encountered. The present work is designed in an attempt to build a systematic procedure for treating warts by carbon dioxide laser regarding dose parameters, application parameters and laser safety.
Patients and Methods: The study done in the department of dermatology in Al-Najaf Teaching Hospital in Najaf, Iraq. Forty-two patients completed the study and follow up period for 3 months. Recalcitrant and extensive warts were selected to enter the study. Carbon dioxide laser in a continuous mode, in non-contact application, with 1 mm spot size was used. The patients were divided into two groups. The first group of patients consisted of 60 lesions divided to 6 equal groups, in whom we use different outputs a

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Publication Date
Tue Jul 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Effect of thyroid dysfunction on hemoglobin A1c in polycystic ovary patients during ovulation induction trials.

Background: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders leading to infertility. Majority of women with PCOS have insulin resistance and elevated hemoglobin A1c.The presence of thyroid dysfunction may affect the levels of HbA1c and the results of ovulation induction programs.                                                                    &nbsp

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