Antibiotic resistance is the major growing threat facing the pharmacological treatment of bacterial infections. Therefore, bioprospecting the medicinal plants could provide potential sources for antimicrobial agents. Mimusops, the biggest and widely distributed plant genus of family Sapotaceae, is used in traditional medicines due to its promising pharmacological activities. This study was conducted to elucidate the antimicrobial effect of three unexplored Mimusops spp. (M. kummel, M. laurifolia and M. zeyheri). Furthermore, the mechanisms underlying such antibacterial activity were studied. The Mimusops leaf extracts revealed significant antibacterial activities against the five tested bacterial strains with a maximum inhibition zone diameter of 22.0 mm against B. subtilis compared with standard antibiotic ciprofloxacin. The minimal inhibitory and bactericidal concentration values against tested Gram-positive and Gram-negative bacterial strains ranged from 3.15-12.5 µg/ml. However, weak antifungal effect was recorded against Candida albicans with MIC value ˃25 µg/ml. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay showed that M. caffra was the best antioxidant (IC50=14.75±0.028 µg/ml), while M. laurifolia was the least one (IC50=34.22±0.014 µg/ml). The phenolics in plant leaves extracts were identified and quantified by high performance liquid chromatography (HPLC) which revealed the presence of seven phenolic acids and four flavonoids. The abundant phenolic compounds were rutin (5.216±0.067 mg/g dried wt.) and gallic acid (0.296±0.068 mg/g) followed by myricetin (0.317±0.091 mg/g) then kaempferol (0.113±0.049 mg/g) as flavonoids. The antibacterial mechanism of M. laurifolia extract, as a representative species, induces ultrastructural changes in the model bacterium Staphylococcus aureus with cell wall and plasma membrane lysis as revealed by transmission electron microscopy. Overall, Mimusops species (M. laurifolia, M. kummel and M. zeyheri) are promising natural alternative sources for antimicrobial agents.
The research aims to analyze the relationships of influence and influence between the soft skills of human resources and strategic performance, as the soft skills of human resources constitute the engine for all duties and operations carried out by the organization, and as a result of sharp changes in the environment, it was necessary for this organization to determine the most important financial and non-financial indicators that are required Approving it in achieving strategic performance to ensure its survival and continuity in work. The research problem was represented by a decrease in cognitive awareness of the importance of employing soft skills for human resources in achieving the indicators of strategic financial and non-
... Show Moreأهمية الدراسة والحاجة اليها:
يعد النشاط المدرسي للمعلم والطالب جهدا عقلياً وبدنياً يبذله المعلم والطالب بمساعدة المدرسة لتحقيق اهداف مرسومة وهو ممارسة تظهر في اداء الطلبة على المستوى الحركي والفعلي والنفسي والاجتماعي بفعالية داخل المدرسة وخارجها. (اللقاني،بلا، ص82).
ان الانشطة والبرامج المدرسية التي تنظم داخل الصف
... Show Moreيدور هذا البحث حول جمع الالفاظ التي تتعلق بأعضاء جسم الانسان في ديوان محمد مصطفى الماحيّ, وترتيبها في حقول دَلاليّة على وفق دراسة معجمية, تناولت فيها الالفاظ التي تتعلّق بأعضاء جسم الانسان, فكان الهدف من هذه الدراسة هو دراسة الألفاظ التي ترتبط دَلالتها بمفهوم عام يجمعها حقل دلاليّ واحد كجمع الفاظ (الرأس, والعين, والانف), تحت مفهوم (أعضاء الانسان) وبيان العلاقات الدَلاليّة بين هذه الالفاظ, كــ (الترادف والمشترك
... Show MoreThe paper deals with the contemporary American playwright, Kenneth Bernard,
and his Theatre of the Ridiculous. This theatre, which originated in the 1960s and
1970s, aims at undermining dramatic and social conventions, and political,
psychological, sexual, and cultural categories. It makes use of mass culture
entertainment in America (television, popular songs, old movies, the circus) in its
attempt to make us recognize the world as “ridiculous,” a world which is both
brutal and farcically trivial and insignificant, a world of ruthless powers, of freaks,
clowns, and victims, of hysteria and absence of truth, a world, as Bernard describes it,
“without hope, mercy, history, or any saving sociology or ideology.
يدور هذا البحث حول جمع الالفاظ التي تتعلق بعناصر الطبيعة السماويّة وظواهرها في ديوان محمد مصطفى الماحيّ, وترتيبها في حقول دَلاليّة على وفق دراسة معجمية, تناولت فيها الالفاظ التي تتعلّق بعناصر الطبيعة السماويّة وظواهرها, فكان الهدف من هذه الدراسة هو دراسة الألفاظ التي ترتبط دَلالتها بمفهوم عام يجمعها حقل دلاليّ واحد كجمع الفاظ (السماء،والقمر، والبدر، والنجم، والكوكب), تحت مفهوم (عناصر السماوية وظواهرها الطب
... Show MoreThe intensification of competition in the business environment has forced research organizations to develop marketing dynamics that help them to sense and conceptualize market opportunities and uncertainties. Then, the marketing capabilities of the organization are restructured and developed according to mechanisms such as speed, timing, and frequency of application. The problem of most organizations is their lack of interest in capabilities Marketing dynamics, which represent the most important factor in enhancing their marketing performance, so the objective of the research is to identify the most important capabilities that banks should pay attention to and evaluate their role in determining the strategic direction of th
... Show MoreColorectal cancer CRC is the third most commonly diagnosed cancer in males and the second in female, so it is a common and life-threatening disease serum of 48 males and 40 females suffering from CRC disease as group one (G1) without taking a chemotherapy dose, the same patients group tow (G2) after taking the first chemotherapy dose, while group three (G3) whose patients in (G1) and (G2) after second taking a chemotherapy dose. and group four (G4) consist of (30 males and 30 females) healthy Iraqi control. Results showed a significant increase in IL-17, IL-17RA and CEA in G1, while there was a significant decrease in vitamin D concentration in G1 than other groups, also there was positive (+ ve) significant correlation between IL-17 and CE
... Show MoreIncremental Sheet Metal Forming (ISMF) is a modern sheet metal forming technology which offers the possibility of manufacturing 3D complex parts of thin sheet metals using the CNC milling machine. The surface quality is a very important aspect in any manufacturing process. Therefore, this study focuses on the resultant residual stresses by forming parameters, namely; (tool shape, step over, feed rate, and slope angle) using Taguchi method for the products formed by single point incremental forming process (SPIF). For evaluating the surface quality, practical experiments to produce pyramid like shape have been implemented on aluminum sheets (AA1050) for thickness (0.9) mm. Three types of tool shape used in this work, the spherical tool ga
... Show MoreThe concept of intertextuality was one of the problems that occupied the attention of critics and critics in targeting the structure of textual intertextuality between texts and their overlap in the process of producing meaning. Until intertextuality became a stable term and it can be monitored in the structure of the theatrical text and determining the mechanisms of this intertextuality between texts through fields and classifications agreed upon by the most important critics who wrote and considered intertextuality. Perhaps our previous research (the approach of exposure in the epistemological hallway to intertextuality) was an attempt to interview a terminology, which the researcher intended to monitor, through the mechanisms of inter
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