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bsj-3199
Silver Nanoparticles and their Role in Gene Expression of Motility Gene motB and Repression of AI-2-Controlled Gene
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Antibiotic resistance is the capability of the strains to resist or protect themselves from the effects of an antibiotic. Such a resistance towards the current antimicrobials leads to the search of novel antimicrobials. Nanotechnology has been promising in different field of science and among it is the use of nanoparticles as antibacterial agents. The gastrointestinal tract seems to be the primary reservoir of uropathogenic E.coli (UPEC) in humans. UPEC strains harbour the urinary tract and cause urinary tract infection. They cause serious ailments in terms of humans. They develop resistance and increase their virulence by forming biofilms. They also show a remarkable locomotory movement with the aid of autoinducer controlled genes (AI-2).

The present study is designed to investigate the expression levels of the AI-2 controlled genes and the motility genes in the presence of nanomaterials. RT PCR amplification together with the antibacterial and motility studies were done to compare the significant effect of silver nanoparticles on the pathogen. S-adenosylmethionine assay was also done to confirm the role of the treatment on the repression of the AI-2 genes.  

The results showed silver nanoparticles have significant effect on the motility studies. The relative expression and repression of motB gene was under the control of AI-2 kinase protein. This confirms the possible role of the nanoparticles towards the pathogen UPEC. There was also an inhibition on the biofilm formation under the effect of the nanoparticle treatment. The study concludes that the silver nanoparticles could be used as a novel antibacterial agent against the UPEC strains and thereby inhibits the antibacterial resistance.

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Publication Date
Sat Apr 17 2021
Journal Name
رؤوية افريقيا
المصالح الفرنسية في القارة الافريقية بعد عام 2000
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Publication Date
Fri Jan 04 2019
Journal Name
Journal Of Planner And Development
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Tue Sep 27 2022
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Arab Science Heritage Journal
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Publication Date
Tue Dec 11 2018
Journal Name
Arab Science Heritage Journal
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Publication Date
Sat Aug 10 2013
Journal Name
Journal Of Accounting And Financial Studies (jafs)
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Publication Date
Fri Jan 05 2024
Journal Name
Al-academy
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Publication Date
Sat Jan 01 2005
Journal Name
Journal Of The College Of Languages (jcl)
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Publication Date
Sun Sep 23 2018
Journal Name
مجلة آداب المستنصرية
خيوط الواقع والسرد الروائي في رواية (غراب الطاهرة)
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Publication Date
Mon Feb 02 2026
Journal Name
Journal Of Babylon Center For Humanities Studies
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Publication Date
Thu Dec 31 2015
Journal Name
مجلة كلية العلوم الاسلامية
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