Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
Abstract The Kenyan policy towards Somalia was influenced by a set of interrelated factors between the two countries and stemmed from the internal environment and most prominent: the geographical factor, ethnic, cultural, religious, political, economic and security, has been dominated by this policy since independence from the British colonial administration in the sixties of the last century and so far the nature of instability and tension, As the two countries are geographically contiguous and as security risks escalate, Kenya in 2011 rushed military action against Somalia, the first military action by Kenya outside its borders since independence.
يعد الأمن البيئي موضوعاً حيوياً لا سيما في العصر الحديث، حيث بدأت تحديات التغير المناخي تتدهور وبسرعة متزايدة. وتزداد أهمية هذا الموضوع مع تصاعد تلك التحديات، أذ يتعين على الجميع لا سيما النساء منهم المشاركة في الحفاظ على البيئة لضمان استدامتها للأجيال الحالية والمستقبلية. ويُعد الحفاظ على البيئة والموارد الطبيعية أمراً ضرورياً لضمان استدامة الكوكب ومستقبل الأجيال القادمة. وفي هذا السياق، يأتي دور المرأة
... Show Moreتم ت داول مصطلح الأزمة ا دلولية في السياسية ا دلولية خال القرن التاسع عش ر لتحدي دا ملدة الانتقالية بين السلم والحرب سواء أ دت الأزمة إلى نشوب صراع مسلح أم مت ت ت سويتها بالطرق السلمية، وتع دالأزمة ا دلولية مرحلة مت هيدية ل لحرب وهي ا رملحلة التي يسعى فيها أ طرا فالأزمة إلى إبعاد احتمالية نشوء أ و اندلاع الحرب، فالأزمة ه ي مدة حرجة ومرحلة خطيرة بين وقتي السلم والحرب، إن العلاقات ا دلولية تكاد ت عيشأ زمات متلاحقة ع
... Show MoreDo’a and Zikr al-Mā’thur (authentic supplications and remembrance of ALLAH ‘Azza wa Jalla) can be suggested to Muslims to help them deal with challenges or issues in life. Counselling cases affect a person’s feelings. Do’a and Zikr al-Mā’thur are often applied as a counselling intervention. Unfortunately, the authentic Do’a and Zikr al-Mā’thur are dispersed in many resources not visible to users, and the fact that not all online resources offer access to accurate Do’a and Zikr al-Mā’thur to users and the dubious Do’a and Zikr al-Mā’thur frequently credited to the Prophet (pbuh). The goal of this research is to develop an ontology
... Show MoreOf good reasoning (the art of unique moral turn him poets of Andalusia in
poetry verse emitter myself, and to achieve a very technical. Either the emitter is
related to the nature of the environment and the composition of personal Andalusia
of appetite for life and interaction with the legibility beautiful, and it was (wit)
feature in them even said they are charming as Bagdad ions , and either art, it made
them this color to show their ability intellectual in the search for bugs, and
stimulate their imaginations in a contract equations in the interpretation and find
justifications for the ideas and meanings Exaggeratedly times, and especially in the
purpose of praise, and novelty in many cases, as in the spinning
The povety in a subjct of one of the most important problems that
accompanied the development process in iraq and is now pointing in the
depth of institutional struetues and threaten the sociol fabric and cohesion
mechamisms .
The study included of the most importana social problems that
accompamied thecrises and occupation in iraq as aproblem of unemployment
aworce, forced displacement and disintegration of family and juvenile
delinguency and the problems of drug addiction .
The study relied on sample slected from the city of Baghdad ,showed
the most important results of that two-thirds of the asssets of an urban sample
compared to one third of them from rural aelcyrounds and that there is
arelationship
البنية الاقتصادية الاجتماعية للادارة الجديدة في الولايات المتحدة الامريكية
مثل الوعي الطبقي اعلى مراحله لدى الفكر الماركسي الحديث عند كل من ماركس وانجلز ولينين ليس مجرد انعكاس للواقع وانما يكون بصورة جدلية من خلال انعكاس الوعي على الواقع واعادة انتاجه فبعد ان كان الوعي هو نتاج تطور الواقع اصبح اداة في تطوير الواقع، أي تأثير البنى الفوقية على البنى التحتية( المادية التاريخية) بعكس ما دعى اليه ماركس، اذ أعطى لينين للوعي دوراً كبيرا في التطور التاريخي، وعد الوعي الطبقي هو الاداة التي
... Show Moreتكمن مشكلة البحث بان المؤسسات عامةـ والتعليمية منها خاصةفي الوقت الحاضرتواجه ظروف بيئيةتفرض عليها حتمية التغيير ، وذلك بسبب التحولاتالتي تحدثفي عالمناالحالي سواءًكان على المستوىالمحلي أو العالمي أو على المستوىالمؤسسة نفسها مما يجعلمؤسساتنا التربويةبحاجةملحةلمواجهة هذا التغيير القادم وذلك من خلال معالجةالمشكلاتالتي قد تظهر بطرق مبتكرة وابداعية مغايرةللطرقالتقليدية ،وذلك من خلال تهيئة المناخ الت
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