Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
The Abbasid Caliphate generally paid attention to the financial aspect through the collection of resources , And also in terms of spending these resources
The main target of this research is to follow the stages of the emergence of
the idea of republican form of government from its very beginning , yet there
were many elements from different estates thinker , educated , few of heads of
clans . This first opportunity for the mobilization of politically-minded people
with fundamental activity like najei shokat . hussain al-rahal notable poet maruf
al-rasafi those who formed what so called the political elite who believed in
constitutional , democratic parliamentary republic , one of them was al-rahal who
called for a constitutional republic even before the emergence of the
constitutional movement in Iran and ottoman empire (1908).
The holy najaf become cultural cen
In this research I like to shed light on the mind because of its importance because it is what distinguishes Human from all other animals and that the question and status comes from his role in the formulation of knowledge and science where the machers agreed that the word of mind in its general sense is the source of thought and thought and the instrument of faith and philosophy , Then to the statement of the various stages pass
... Show Moreيتناول البحث الحماية المدنية للمستهلك في المرحلة السابقة على التعاقد الالكتروني
הריאליזם הספרותי במשמעו הכללי מצייג אשר כל מה מציינת בה הספרות מציורים מדוייקים לסביבה ולכן
אדם. ויש להתחשב בפרטים המשותפים לחיים היומיומית.
האסכולה הריאליזטית מצטיינת בזיאנרים אין זוכים בם איזו אסכולה ספרותית אחרת . האסכולה הזאת
הופיעה בספרות העברית החדשה כתוצאה להשפעתה של הספרות העברית בספרות העולמית האחרת ,
והמספרים העבריים בתנוטה הספרותית החדשה השתדלו במאמצים גדולים למען להתפתח את התנועה הזאת
Psychological Counseling Services occupies a high position in the developed countries and that for its psychologist services for different sectors of the community members, and has been popularized until recently the wrong concept of the effect, that the psychological service is provided only to the owners of behavior is normal only, Vantage him neglect to provide psychological services a large segment of the community members who are in dire need of these services.
The counseling service is part of a global social movement seeking to emphasize the quality of life of the human and the emphasis on the value and dignity and the need to live a quiet lif
... Show MoreThe insects like other creatures in the wide world, and there are more than a million class and type of these objects, some of which human haunted since the old to the present day.
In this study highlight the insect bee addressing her life and behavior, and the novelty of her and wonders what mystified by the minds of men that her world is full of mysteries and surprises drew the attention of workers in the natural history of the study and scrutiny of methods and different characteristics of scientists as she gives more than it takes. It appeared that the Islamic heritage has singled out these insects with something of interest and precise detail, but that God Almighty made suras from the Koran carrying insect name two Sura
... Show More