Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
مشكلة البحث:- تواجه المجتمعات العربية في المرحلة الراهنة ,تحديات كبيرة تستهدف الشاب العربي ،والتأثير عليه في الجوانب الاجتماعية والتربوية والثقافية والاقتصادية والأمنية والسياسية ولغض تسليط الأضواء على هذه الجوانب ولاسيما الجانب الاجتماعي،من هنا تبرز مشكلة البحث الحالي في التعرف على توقعات الشباب العربي لمشكلاتهم الاجتماعية في المرحلة الراهنة .
أهمية البحث:-
... Show MoreLiterary heritage and its employment in poetry has received the attention of poets, and they have employed it in their literary texts, as this employment is one of the oldest phenomena in Arabic literature, that the inspiration of this heritage in texts through the overlap of their texts with previous texts, and no poet neglected the importance of this employment. The ancient critics determined that the poet’s special culture is represented in the necessity of taking from the ancients, and this taking is the reference from which the poet draws his material and idea, as well as to clarify the meaning and its significance
This research paper sheds light on the stages of Atmospheric forecast in Iraq. It was found that atmospheric forecast in Iraq has passed through several successive and interrelated historical stages. Each stage is characterized by special methods of prediction that are different from other stages. The oldest stages used astronomy to forecasting cases of cold , heat, flood and drought
يهدف هذا البحث الموسوم بـ (المنهج النقدي في كتاب الرجال للنجاشي(ت 450هـ )إلى تسليط الضوء على حياة النجاشي ومكانته العلمية والكشف عن منهجه النقدي في كتابه المذكور.
من المتفق عليه أن هناك طريقا واحدا لنشر الثقافة والقضاء على الجهل هو التعليم .ولعل أبرز ماشهدته مدينة بغداد من تطور هو ظهور المدر سة ومن ثم إنتشارها بشكل كبير وفق المفهوم الحديث مما أثرفي عموم الحياة اليومية ، ومن ضمنها التعليم العالي .إن الإستقرار من أهم ماتحتاجه الجامعة للقيام بواجباتها ولايأتي الإستقرار إلا بالإستقرار الذي يضمن لنا أن تكون الجامعة بعيدة عن ما قد يستجد من الأهواء و النزاعات.
The correct and sincere process of socialization is working on appropriate social climate in
which this process is the provision, and the climate is achieved in the presence of a positive
environment free of negatives and contradictions, but when there is a socialization processes
inadequate and contradictory was not based on the principles of punishment and reward nor a
balance between methods soft and intensity of treatment and interaction with small and
adolescent does not require intensive social care formulas do not create the conditions
essential items required by the successful and effective socialization, the young and the young
people who are going through in such Altanisah and educational operations will be
There are many researches deals with constructing an efficient solutions for real problem having Multi - objective confronted with each others. In this paper we construct a decision for Multi – objectives based on building a mathematical model formulating a unique objective function by combining the confronted objectives functions. Also we are presented some theories concerning this problem. Areal application problem has been presented to show the efficiency of the performance of our model and the method. Finally we obtained some results by randomly generating some problems.
- Aim of the current research is to know the impact of guided discovery strategy sports communication skills among students in first grade average in mathematics.
- , Consisted sample of (58) a student from a school Baghdad Rusafa, divided in two groups, one experimental studied according to strategy discovery The second group studied the traditional way, the researchers built search tool (test communication skills sports), and using a number of statistical methods including : -
- Test (t - test) was used to independent samples to examine the match Mediterranean experimental and control groups and tested Levin (Leven - test
السياسة في الفلسفة الاسلامية : الفكر السياسي عند الفارابي
התמצית השניות היא התורה שנזכרת כי המוצאים בלשון הערבית וכך בלשונות השמיות אינם הבטויים בעלי האותיות השלושיות , אלא בעלי שתי אותיות . לפי כך אפשר להשיב השורשים השלושיים לשורשים השניים . וכל אות שנאספה בשורש שׁניוני, יהיה לפי חוק ההתפתחות הלשונית , הוספות תחילית , תוכית , סופית , עם השארת החיבור המשמעתית בין השׁניוני והשׁלשׁי כמו היא ממושכת בין השׁלשׁי והרביעי ומה שרבה ההוספות . השרשים השניים מוצאים הם: אות וה
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