Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
Fraud Includes acts involving the exercise of deception by multiple parties inside and outside companies in order to obtain economic benefits against the harm to those companies, as they are to commit fraud upon the availability of three factors which represented by the existence of opportunities, motivation, and rationalization. Fraud detecting require necessity of indications the possibility of its existence. Here, Benford’s law can play an important role in direct the light towards the possibility of the existence of financial fraud in the accounting records of the company, which provides the required effort and time for detect fraud and prevent it.
التجليات الاقتصادية والثقافية والاعلامية للعولمة في العالم الثالث
That is feared we frequent urgent calls from Islamic scholars and leaders of the Muslim faithful to their religion and nation to a culturally، economically، politically and militarily Muslim communities، in response to the call of the divine stones in the sit-rope of God and taking the greatest causes of strength and stamina، pride and empowerment، and did not bear fruit this repeated calls only sham gatherings and links formality not have the effect of rewarding challenges، and it was one of the greatest causes of failure that impact the absence of a proper understanding of the basis of the Islamic Alliance، and lack of consensus on the Thoroughbred clear vision of Islamic unity
The letters draw clear picture for what had happened in that time it was full of incidents .that incidents had began with the byzantine invation and persioan persecution .later on the Muslins managed to conquest Iraq and Persia .the muslims spread peace and security for the pupils of that area.
Ishuib manged to achieve peace and security to his adherence .he proved that he was one of those who were aunique persons. Because he did his beast to active and revive the general and special life to his adherence. He succeeded to organize the Christian relation ship with the muslims .
He wrote an agreement with muslims .he thought that this Islamic canquest was from allah to die done the mazdism. He said t
... Show MoreThis research discussed the freedom of Iraqi women in the thought of Dr. Nazeeha Al-Dulaimi.
Prophecy in general, and Muhammadism in particular, can not seem to go away from life, or lag behind it, because it was originally for reform. It can not succeed in achieving this reform. It has grown away from it, and its conditions have not caused it to vary and diversify. These conditions, from its origin to its tranquility, its stillness and its movements, are based on a wise divine workmanship and a strict divine planning that suits the performance of this personality
تتباين القراءة والكتابة من ناقد لآخر تبعا للموضوع الذي يتناوله، وطبيعة المادة، والمكونات المعرفية التي تؤسس فهمه، فمنهم الناقد التقليدي الذي يتبع السائد في نقده للمادة الفنية اما بالموافقة والتبني أو بالمغالطة والقدح، ومنهم الناقد المقلد الذي ينتخب اتجاها غربيا يرغب في تطبيقه على جزء من النصوص التي انتقاها، ومنهم الناقد الذي يتبع أفكاره ويدمجها مع النص ناقد مختلف يبحث في ما يذلل من قواعد، يحلل ويشرح وفقها
... Show Moreנסיון השביה בספרות המלחמה העברית יותר מביעה למרחק בסיכולוגי אצל הלוחם העברי ,
אני מעמד מול הנושא הזה , כי אני כותב בהמחקר הזה נסיון השבוי והשפעתו בציור הדמות אצל
הסופר '' יזהר סמילנסקי ) 1916 – 2006 ( " , סופר עברי יליד ישראל , נודע בכינוי תספרותי '' ס .
יזהר " מחשובי היצורים בספרות דור הפלמ''ח בפרט ובספרות העברית והכללית . חתן פרס ישראל
לספרות לשנת ) 1959 ( – כידד הגשם דמות ה '' אני '' וה '' אנחנו '' לגלה את ספל השבוי היחיד כ
LA TRANSGRESSION CHEZ RIMBAUD Lecture de I' aspect de Transgression dans Marine
По мнению ученых, исследующих современные деривационные процессы, „начиная со второй половины XX в., активизируются новые социолингвистические и коммуникативные факторы”, определяющие специфику современного словотворчества в ряде типологически близких славянских языков [Нещименко 2010: 39]. В результате возросшего влияния масс-медиа на коллективное сознание носителей языка, на существующий вербальный
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