Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
Alienation, and Westernization and away, whether forcibly sense exile or voluntary in the sense of migration, it will generate nostalgia, and a sense of overwhelming homesickness spatial or alienation spiritual (emotional) and perhaps alienation resulting from exile or forced deportation by the authority
أرادة الذات بين الأستلاب والأسترداد في قصيدة البياتي
تعد رواية (غراب الطاهرة ) من الروايات المعاصرة التي ركزت على الواقع المعاصر، وهي تمثل حقلاً بكراً صالحاً لدراسة العلاقة الحميمة بين ( الواقع ) و ( الشكل البنائي ) وأثره في بنية النص الروائي، بمعنى آخر دراسة القوانين التي توجه أنماط التأليف، وحرية الأختيار في صياغة العمل الفني.إذ إن اهتمام المؤلف بالتوثيق التاريخي، وتسجيل أهم المظاهر الواقعية، ومايرتبط بها من ممارسات النظام السابق أثرت في البناء الروائي، فمن حي
... Show Moreالقواعد الفقهية، باب واسع لإنزال الحكم الشرعي على مستجدات السياسة التي تتزايد يوماً بعد يوم، ومستجدات مسائل القضاء المعقدة، شرط أن تكون القاعدة مستمدة من النصوص الشرعية لفظاً أو دلالة. والأخذ بالقواعد الفقهية في الأحكام التي تخص السياسة الشرعية، أولى بالأخذ من الأحكام الوضعية؛ لأن قواعد الفقه هي خلاصة أحكام توصل إليها فقهاء الأمة بعد الدراسة والتمحيص، وهي مؤهلة وبشكل كبير أن تغطي حاجة أصحاب الولايات الع
... Show MoreHighlights the role of taxes in being a major source of funding sources internal economic and social development, and then, any decrease in tax revenue caused by tax evasion, for example, would weaken the government's ability to finance their investments and core financing private sector investment as a result of reduced ability to increase their reserves's cash banks, as well as the weakening of the effectiveness of tax evasion taxes as a tool to guide economic activity in the framework of service for development, and to achieve justice. And the statement of the reasons for and methods of evasion mandated to pay the tax due on them, whether legitimately or illegal with the statement of the proposed methods to tackle tax evasion and elim
... Show More: The objective of this research is to demonstrate the possibility of applying the principles of corporate governance in the General Authority for taxes, as the goal to identify the basic requirements for the application of the principles of corporate governance in the GCT with an indication of the role of governance in improving the strategic performance of tax administration. The research was based in part applied to the analysis of the results form questionnaire designed to achieve the goal of the research .
لقد أثارت فكرة القانون الطبيعي اهتمام الفقهاء والفلاسفة في الشرق والغرب ، القدامى منهم والمحدثون وشيدوا نظريات وأقاموا مناقشات حول فكرة القانون الطبيعي والطبيعة والعقل الطبيعي مما جعل هذه الفكرة تبدو إحدى المعطيات الأساسية للفكر الإنساني والتي لا يمكن تجاوزها في إي وقت أو في إي مكان. يبدو إن مفهوم القانون الطبيعي وان كان يعد من اعرق المفاهيم الفلسفية إلا انه يعد واحد من تلك المفاهيم التي وان احتفظت بجوهرها
... Show MoreSomal is considered one of the unstable and restless African Arabian country in
comparison with other Arabian. It has been exposed to division and separation by
European colonization process that worked hardly on dividing this country according to
Berlin conference (1884-1885). Even after obtaining its independence during the sixties
and being led by civilian organizations which were unable to solve the problems of
Somalian society after obtaining the independence.
Somal continued its suffering even after the military rule under the leadership of
Mohammed Sayad Beree.
During Beree's rule, Somal suffered from the War with Ethiopia, as well as it
witnessed an economical Crisis. It suffered also from the tribal po