Spectrophotometric method for the determination of Captopril in pharmaceutical formulations

Dawood H. Mohammed; Intesar A. Shehab; Hend Ahmed

doi:10.21123/bsj.2013.10.3.965-970

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Publication Date

Sun Sep 01 2013

Journal Name

Baghdad Science Journal

Volume

10

Issue Number

3

DOI

10.21123/bsj.2013.10.3.965-970

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Spectrophotometric method for the determination of Captopril in pharmaceutical formulations

Spectrophotometry

Captopril

Dichlone

2

3-dichloro 1

4- naphthoquinon

Dawood H. Mohammed

Intesar A. Shehab

Hend Ahmed

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A simple, rapid and sensitive spectrophotometric method has been developed for the determination of captopril in aqueous solution. The method is based on reaction of captopril with 2,3-dichloro 1,4- naphthoquinon(Dichlone) in neutral medium to form a stable yellow colored product which shows maximum absorption at 347 nm with molar absorptivity of 5.6 ×103 L.mole-1. cm-1. The proposed method is applied successfully for determination of captopril in commercial pharmaceutical tablets.

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Publication Date

Sun Apr 25 2021

Journal Name

Egyptian Journal Of Chemistry

Indirect spectrophotometric determination of Mebendazole using n-bromosuccinimide as an oxidant and tartarazine dye as analytical reagent

Jasim

Sumayha Muhammed

Takleef

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Publication Date

Sun Sep 30 2001

Journal Name

Iraqi Journal Of Chemical And Petroleum Engineering

Study the Characteristic Performance of Trickling Filter for Pharmaceutical Waste Treatment

Nahidh W

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Publication Date

Wed Jan 01 2025

Journal Name

Journal Of Advanced Pharmacy Education And Research

Impact of preparation techniques on formulation and characterization of captopril effervescent granules

Ishraq K.

Marwah M.

Saba Abdulhadi

Adnan Burhan

Raffah Khamis

Omar Saeb

Ahmed Abbas

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(3)

Publication Date

Sun Dec 30 2018

Journal Name

Baghdad Science Journal

Optimization and Validation of RP-HPLC-UV/VIS Method for Determination Some Antioxidants in Dry Calyces of Iraqi Hibiscus Sabdraffia Linn

antioxidants

Hibiscus Sabdraffia Linn

Sarah K.

Kareem D.

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A new (Reversed Phase- High Performance Liquid chromatography) RP-HPLC method with Ultraviolet-Visible spectrophotometry has been optimized and validated for the simultaneous extraction and determination of antioxidants present in Iraqi calyces of Hibiscus Sabdraffia Linn. The method is based on using ultrasonic bath for extracting antioxidants. Limit of detection in μg/ml of Vitamin C, Sabdaretine, Gossypetine, Hibiscetine, Anthocyanins, Dephinidin-3-glucoside were113.8294×10-6,123.0453×10-6,70.3681×10-6,59.6730×10-6,148.1710×10-6,and125.3481×10-6 respectively. The concentration of antioxidants found in dry spacemen of calyces of Iraqi Hibiscus Sabdraffia Linn. under study: Vitamin C, Sabdaretine, Gossypetine, Hibiscetine, Anthoc

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Publication Date

Fri Mar 31 2017

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

The Effect of some Variables on the Formulation of Captopril as Tablets Shaymaa Nazar Al â€“ Sammarrai

Dr. Alaa

Dr. Hikmet

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Captopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension,
congestive heart failure, and myocardial infraction.
The only dosage form available for captopril is the plain tablet in strength of 12.5,25,50 and 100mg
tablet.
This investigation is concerned with factors affecting the formulation of captopril as a plain
tablet dosage form of 50mg. Many trials were made to prepare satisfactory tablets for the drug by
using wet â€“ granulation methods with various additives. It was found that poly vinyl pyrrolidone
(P.V.P.) as binder gave the most satisfactory tablets. At the same time a shorter disintegrantion time
and slower dissolution rate were obtained with the addition of starch

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Publication Date

Mon Oct 01 2012

Journal Name

Computers & Mathematics With Applications

Boundary element formulations for the numerical solution of two-dimensional diffusion problems with variable coefficients

M.A.

L.C.

L.

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Publication Date

Sat Feb 09 2019

Journal Name

Journal Of The College Of Education For Women

Visual Modeling Language for Agent Treasury Pharmaceutical

عفاف بديع

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The researches to discover useful ways to represent the agents and agent-based
systems are continuous. Unified Modeling Language (UML) is a visual modeling language
used for software and non software modeling systems. The aim of this paper is: using UML
class diagram to design treasury pharmaceuticals agent and explain its internal action. The
diagram explains the movement of the agent among other nodes to achieve user's requests
(external) after it takes them. The paper shows that it is easy to model the practical systems by
using agent UML when they are used in a complex environment.

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Publication Date

Fri Oct 04 2024

Journal Name

Analytical And Bioanalytical Chemistry Research

Optimization and Validation of a GC-FID/QuEChERS Method for Quantitative Determination of Spiromesifen Residues in Tomato Fruits, Leaves and Soil Matrices

Hanan Abdulsalam

Mohammad K.

Mokhtar

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Pesticides serve a crucial function in contemporary farming practices, safeguarding agricultural crops against pest infestations and boosting production outputs. However, indiscriminate use has caused environmental and human health damage. This study aimed to develop and validate a gas chromatography-flame ionization detection (GC-FID) methodology for the direct and routine analysis of spiromesifen residues in soil, leaves, and tomato fruits. The proposed method prioritizes simplicity by avoiding derivatization steps, offering advantages over existing approaches that utilize lengthy multi-step extraction or derivatization prior to GC analysis. A key novelty of this work is the development of a QuEChERS extraction coupled directly to GC-FID

Publication Date

Mon Feb 14 2022

Journal Name

Proceedings Of The National Academy Of Sciences

Pharmaceutical pollution of the world’s rivers

John L.

Alistair B.A.

Dana W.

Kenneth M. Y.

Racliffe W. S.

Cristóbal

Aiko D.

Julie

Marc

Robert A.

Alejandra

Aida

Anja

Pedro

Macarena

Chris

Magdalena

Monique

Thais

Vahagn

Yekaterina

Clare S.

Christopher J.

Thilo

Tapos

Volga

Jessica

Jean L.

Francisco

Maria T. P.

Victorien

Gildas

Oumar

Jules M.

Linda E.

Michelle

Donald

Romaric

Jaime

Guang-Guo

Chang-Er

Martha

Jina

Jean-Paul

John

Suspense A.

Penelope

Silvia

Nikolina

Milena

Despo

Lida

Vladimíra

Jan

María

Bayable A.

Jeanne

Arnaud

Peter

Ilia

Sven

Gerasimos

Halldór P.

Molly

Thatikonda

Manisha

Anindrya

Adee

Nima

Ali

Omar

Salem S.

Francesco

Benny

Tom

Koffi Marcellin

Bakhyt

Raikhan

Lydia

Jemimah K.

Peter

Victor

Nathaniel T.

Sheck

Ahmad Zaharin

Ley Juen

Mahamoudane

Seydou T.

Rik

Olatayo

Muhammad

Ziad

Aaron

Jorge Manuel

María

Heidi

Ian

Fabio

Alhaji Brima

Bashiru M.

Vesna

Mitja

Melusi

Kyungho

Habyeong

John L. Celestino

Andreu

Priyanie

Anna

Gisela

Armin K.

Alex C.

Jheng-Jie

Rebecca

Madaka

Ulas

Turgut T.

Julius B.

Yuliya

Yuriy

Horacio

Andrés

Douglas B.

Maritza

David

Charles

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Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across

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(1045)

(1022)

Publication Date

Mon Mar 25 2019

Journal Name

Al-academy

The Effectiveness of Implication in New Formulations of the Contemporary Industrial Product: زياد حاتم حربي

Effectiveness of Implication

Contemporary Industrial Product

Ziad

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The current research aims at transforming the concept of implication from the rhetoric into the industrial design in order to have a new term (the design implication) in which the industrial designer takes all or part of another's design to imply his design in it and acknowledge that, and if he did not do so, it would be (design theft) parallel to the literary plagiarism.
In order to show the potentials of the industrial design in the production of new formulations of the industrial products forms, as the design is the carrier of language that addresses the recipients, it is possible to use the implication as a the tool of literature in the design and as a design strategy as it is one of the concepts that takes its course in e

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