Preferred Language
Articles
/
bijps-888
Effects of Hydrochlorothiazide on Tenofovir Disoproxil Fumarate-Induced Nephrotoxicity in Rats
...Show More Authors

Tenofovir disoproxil fumarate, a nucleotide reverse transcriptase inhibitor utilized for the treatment of hepatitis B virus and human immunodeficiency virus infections; and is now one of the most widely used antiretroviral drug. However, tenofovir disoproxil fumarate can induce nephrotoxicity, which may be attributed to the interaction between such drug and the organic anion transporters (hOAT1, and OAT3) with consequent changes in levels of some parameters that may have a role in nephrotoxicity. Thiazide diuretics have high to intermediate potency of inhibition of OAT1s and OAT3; thus, it may possess nephroprotective effects. This study was designed to investigate whether hydrochlorthiazide has nephroprotective effects on tenofovir disoproxil fumarate-induced nephrotoxicity in rats.

Twenty eight healthy adult male albino rats weighing 180-200g were utilized in this study for duration of 5weeks (35 days) treatment. Rats were randomly divided into four groups (7animals each). Group I: Negative control (orally given distilled water) by gavage tube; Group II: Rats orally received 600 mg/kg/day tenofovir disoproxil fumarate by gavage tube; Group III: Rats orally administered hydrochlorothiazide alone at a dose (10 mg/kg/day) by gavage tube, and Group IV: Rats orally administered hydrochlorothiazide at a dose (10 mg/kg/day) plus tenofovir disoproxil fumarate 600 mg/kg/day by gavage tube. On day 36 of the study, after euthanization of each animal by diethyl ether, 3-5ml of blood samples were collected from each rat by an intra-cardiac puncture, then centrifuged at 3000 rpm for 15 minutes to obtain serum, which was then transferred into suitable plain tubes and preserved at -20 °C; and it was utilized for the estimation of cystatin C and IL-10 level.

Rats administered tenofovir disoproxil fumarate for 5 weeks (group II) produced a significant -elevation (P<0.05) in serum cystatin C level and –reduction in serum IL-10 levels compared to negative control group (group I); similarly,  administration of hydrochlorothiazide alone to rats (group III) produced a significant -elevation (P<0.05) in serum cystatin C level and –reduction in serum IL-10 levels compared to negative control group (group I); also, rats administered combination of hydrochlorothiazide plus tenofovir disoproxil fumarate to rats for 5 weeks (group IV) produced significant elevation (P<0.05) in serum level of cystatin C, and a significant reduction (P<0.05) in IL-10 serum level in treated rats compared to the corresponding levels of negative control animals (group I); beside that in (group IV) rats there were significant reduction (P<0.05) in serum level of both cystatin C, and IL-10 in treated rats compared to the corresponding levels compared to TDF-treated (group II). In conclusion, treatment with hydrochlorthiazide plus tenofovir disoproxil fumarate in an attempt to prevent nephrotoxicity induced by tenofovir disoproxil fumarate is not attained.

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Mon Jul 01 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Prevalence Of Hypothyroidism In Chronic Kidney Disease Among Sample Of Iraqi Patients.
...Show More Authors

Background: Patients with chronic kidney disease have multiple alterations of thyroid hormone metabolism in the absence of concurrent thyroid disease. These may include elevated basal TSH values, which may transiently increase to greater than 10 mU/liter, blunted TSH response to TRH, diminished or absent TSH diurnal rhythm, altered TSH glycosylation, and impaired TSH and TRH clearance rates. In addition, serum total and free T3 and T4 values may be reduced, free rT3 levels are elevated while total values are normal, serum binding protein concentrations may be altered, and disease-specific inhibitors reduce serum T4 binding .
Objective:. To assess the prevalence of hypothyroidism and u/s abnormalities of t

... Show More
View Publication Preview PDF
Crossref (3)
Crossref
Publication Date
Fri May 31 2019
Journal Name
Journal Of Legal Sciences
The legal effect of Licensing contracts in the field of oil investment
...Show More Authors

Iraq is currently the third largest oil reserves in the world after Saudi Arabia and Iran, which is estimated at (115) billion barrels, in addition to the gas reserves of (119) trillion cubic meters so foreign oil companies have been competing for contracts to participate in production and technical service for years to sign the cost of operations The high productivity, which is based on the payment of the term, which leads to raising the cost of production per barrel, which comes mainly from the employment of foreign workers with high salaries and the provision of local services of high standard and purchase of commodity and consulting services worth hundreds of millions of dollars. And the presence of maneuvering and manipulation by fo

... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon Jan 10 2022
Journal Name
Iraqi Journal Of Science
Experimental Study of Pulsed Electrical Discharge in Cylindrically-Tipped of Plasma Switch
...Show More Authors

In this research pulse high voltage circuit was used including resistance,
inductance and capacitor to achieve an experiment of cylindrically-tipped of plasma
switch .The charging voltage of up to 9kV using Rogowski coil and current-shunt
resistance (CVR) used to measure pulsed electrical discharge (PED). The current in
both self-triggering and third-electrode triggering modes. The pulsed current peaks
4kA and the duration of circuit pulses were recorded between 0.1μs and 0.3μs. The
experimental results has shown clearly the inductance effect in the circuit parts in
under damped oscillation regarding the value of circuit parts in addition to the
distance of the spark gap cylindrically-tipped electrodes during th

... Show More
View Publication Preview PDF
Publication Date
Sun Dec 09 2018
Journal Name
Baghdad Science Journal
Evaluation of the Ecosystem Services of the Central Marsh in Southern Iraq
...Show More Authors

Ecosystems provide humans with services that include benefits from food, fresh water, climate regulation, and socio-economic assets. The Mesopotamian marshlands are among the largest wetlands in the Middle East and they provide various benefits. However, ecosystem services of the Marshlands are consistently undervalued in national economic analysis and decision making. This study focusses on the Central Marshes, the first National Park in Iraq, and is the first attempt at valuing a series of ecosystem services from a valuable natural ecosystem in Iraq. We adopted the Toolkit for Ecosystem Services Site-Based Assessment (TESSA) for the determination of biophysical and economic values of services at the site level. Data on key ecosystem se

... Show More
View Publication Preview PDF
Scopus (5)
Crossref (1)
Scopus Clarivate Crossref
Publication Date
Tue Sep 30 2008
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
COMPUTATIONAL ANALYSIS OF THE MIXING ZONE IN THE COMBUSTION CHAMBER OF RAMJET
...Show More Authors

A theoretical analysis of mixing in the secondary combustion chamber of ramjet is presented. Theoretical investigations were initiated to insight into the flow field of the mixing zone of the ramjet combustor and a computer program to calculate axisymmetric, reacting and inert flow was developed. The mathematical model of the mixing zone of ramjet comprises differential equations for: continuity, momentum, stagnation enthalpy, concentration, turbulence energy and its dissipation rate. The simultaneous solution of these equations by means of a finite-difference solution algorithm yields the values of the variable at all internal grid nodes.
The results showed that increasing air mass flow (0.32 to 0.64 kg/s) increases the development o

... Show More
View Publication Preview PDF
Publication Date
Mon Mar 08 2021
Journal Name
Baghdad Science Journal
Gender differences in achievements among students of the Iraqi college of medicine
...Show More Authors

This study was conducted to test the hypothesis that the duration of time spent by the student inside the examination rooms answering the all kinds of written ex-amination questions has some kind of a positive effect on the final score he will get from that exam. And if there arc gender differences in this respect. Students and methods: Data on the final examinations of the autumn quarter was gathered on 892 examina-tions conducted at the end of this quarter , this included male participants of 566 and females of 326. Examinations were on twenty different subjects , including all of the first five years of the undergraduate students of Iraqi College of Medicine for the academic year 2002 — 2003 . The scheduled time of the examinations was

... Show More
View Publication Preview PDF
Publication Date
Sat Mar 01 2008
Journal Name
Al-khwarizmi Engineering Journal
Corrosion of Carbon Steel Pipeline in Flow System of water Sweetening Plant
...Show More Authors

The electrochemical behavior of carbon steel in water sweetening station in Libya has been studied in the range of ( 293–333 oC) using weight loss technique. Measurements were carried out over a range of Reynolds number (5000 – 25000).An apparatus was designed for studying the corrosion process in the turbulent regime, which is of industrial significance. It was found that The corrosion rate of carbon steel in water sweetening station is under diffusion control and increases with increasing Reynolds number. On the other hand the variation of corrosion rate with temperature in the range of (293–333 oC) was found to follow Arrhenius equation and the activation energy approximately the same except at low Reynolds

... Show More
View Publication Preview PDF
Publication Date
Thu Nov 08 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Impact of social phobia upon self-esteem of nursing collegians' in Iraq
...Show More Authors

Objective(s): The aim of this study is to assess the impact of social phobia upon self-esteem of nursing
collegians.
Methodology: A Cross-sectional study is carried out at University of Baghdad, Karkuk, Thi-Qar, and Kufa,
colleges of nursing from Feb 8
th
, 2011 to Sep. 25th, 2011. A sample of all first class nursing collegians (N=330)
were selected from a probability sample of nursing colleges by dividing Iraq to three geographical areas (South,
North, and Middle Euphrates) in addition to Baghdad. The data were collected through the use of selfadministered
technique as a mean for data collection, by using a questionnaire that consists of three parts:
First part was the socio-demographic data form; the second o

... Show More
View Publication Preview PDF
Publication Date
Mon Jul 29 2019
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Ultrasound Findings of MammographicallyDense Breasts in a Sample of Iraqi Female PatientsDOI:https
...Show More Authors
Background: Breast problems including breast cancer have been increasing in Iraq during the recent years. Yet, early detection and screening programs using mammography mainly with complementary ultrasound had dramatically decreased the mortality rates from this emerging disease.
Objective: To assess the dense breast detected by mammography for the presence of any hidden
suspicious lesion by using ultrasound.
 Patients and methods:  this is a cross - sectional study on 53 female patients who came for breast cancer
screening or attended the Breast Clinic in the Oncology Teaching Hospital of the M
... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon Nov 29 2021
Journal Name
Iraqi Journal Of Science
Assessment of water Quality Index of Gr oundwater in Al-Khadhimiya city
...Show More Authors

The present study deals with the assessment of water Quality Index to theAl-
Khadhimiya Groundwater city, by collection groundwater from 13wells during four
seasons, subjecting the samples to a comprehensive physicochemical analysis. The
13 parameters have been considered: pH, total hardness, calcium, magnesium,
turbidity, nitrate, electrical conductivity, total dissolved solid, Sulfate, Chloride,
zinc, manganic, and iron, that are used for calculating the WQI. From the result
shown, the most groundwater quality lies in Unfit for human drinking purpose. The
wells (1 and 11) and wells (3 and 10) were a bad water quality for drinking purpose
since they lie in poor and in very poor respectively according to the WQI.

... Show More
View Publication Preview PDF
Crossref (1)
Crossref