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The Prevalence of UGT1A1*93 and ABCC5 Polymorphisms in Cancer Patients Receiving Irinotecan-Based Chemotherapy at Al-Najaf Al-Ashraf
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Irinotecan (CPT-11) is a semisynthetic derivative of the antineoplastic agent camptothecin used in a wide range as an anti-cancer agent in many solid tumors because of its cytotoxic effect through the interaction with the topoisomerase I enzyme. The major limiting factors for irinotecan treatment are its association with potentially life-threatening toxicities including neutropenia and acute or delayed-type diarrhea, results from distinct interindividual and interethnic variability due to gene polymorphism.

This is a cross sectional pharmacogentics study was conducted on 25 cancer patients to estimate the prevalence of UGT1A1*93 and ABCC5 allele single nucleotide polymorphism (SNP) in Iraqi cancer patients treated with irinotecan-based therapy at Middle Euphrates Cancer Center. Four drops of venous blood was drawn for each patient and was applied onto the FTA classic card to perform a genotyping assay for the 2 SNPs. After DNA isolation and purification, real time PCR was performed to detect the SNPs of each gene.

Results of this study showed the prevalence of one allele variant (heterozygous mutation) of UGT1A1*93 was 64% compared to 36% of patients were wild type to this SNP. No patient (0%) could be detected with homozygous polymorphism of the UGT1A1*93. For the ABCC5 polymorphism, results revealed that 32% of patients have one polymorphic allele (heterozygous), while 28% of them have two polymorphic alleles (homozygous mutation). Wild type ABCC5 gene constitutes 40% of patients.   As a conclusion, high prevalence of UGT1A1*93 and ABCC5 polymorphic alleles were detected in patients at Middle Euphrates Cancer Center which may explain the high toxicity features associated with irinotecan therapy. 

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Publication Date
Mon Jan 30 2023
Journal Name
Iraqi Journal Of Science
Assessment of Shatt Al-Arab Water Quality Using CCME/WQI Analysis in Basrah City of South Iraq
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     The Water Quality Index (WQI) is an important parameter in describing the water resources' suitability for human uses and is one of the most effective methods of describing water quality and indicative of assessing water quality and suitability for human utilization and the health of ecosystems. WQI of the Canadian Council of Ministers of the Environment (CCME) was used in the study to describe the Shatt al-Arab water quality in Basrah Southern Iraq, and its suitability for drinking use. The data for analyzing river water samples were adopted from five stations along the river every month during the years from 2014 to 2018 by the Iraqi Ministry of Environment, as it included the measurement of acidity function PH, Dissolved Oxyg

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Publication Date
Tue Dec 15 2020
Journal Name
Journal Of Baghdad College Of Dentistry
Caries risk assessment of a sample of children attending preventive specialized dental center in Al Resafa, Baghdad
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Background: Young children’s oral health maintenance and outcomes are influenced by their parent’s knowledge and beliefs, which affect oral hygiene and healthy eating habits. This study aims at assessing caries risk in children aged 6 months to 6 years attending the Specialized Center of Preventive and Pediatric Dentistry Center at Al-Resafa sector in Baghdad. Materials and Methods: A cross-sectional study was conducted from 15 May – 15 June 2018, all children attended the center (80 children) were assessed by using the standard caries risk assessment tool of the American Academy of Pediatric Dentistry (AAPD). Results: The highest percentage of children was as follows: no fluoride exposure 44(55%), did not brush 46(5

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Publication Date
Sun Jun 11 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Impact of Al-Rasheed Power Plant Effluents on Biodiversity of Benthic Fauna in Tigris River, Southern Baghdad
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  Quantitative and qualitative composition of benthic invertebrate communities was studied during the period from January to December2012 at four stations that were selected on the Tigris River at Baghdad Province. One of the stations S2 located near Al-Rasheed Power Plant (RPP) to represent the ecological features of the plant site, whereas other stations, S1 were located at  the upstream of the RPP as a control station to investigate the ecological characters of the Tigris River.  Moreover, the two other stations S3 and S4 were located down to the impact of RPP to reflect the possible effects of the plant on the ecology of the river by comparison with the control stations. The present study recorded 44 taxa belong to 4 o

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Publication Date
Tue Feb 01 2022
Journal Name
Materials Chemistry And Physics
Structural, surface electronic bonding, optical, and mechanical features of sputtering deposited CrNiN coatings with Si and Al additives
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Publication Date
Sat Nov 28 2020
Journal Name
Iraqi Journal Of Science
Survey Based Study: Classification of Patients with Alzheimer’s Disease
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 Neuroimaging is a description, whether in two-dimensions (2D) or three-dimensions (3D), of the structure and functions of the brain. Neuroimaging provides a valuable diagnostic tool, in which a limited approach is used to create images of the focal sensory system by medicine professionals. For the clinical diagnosis of patients with Alzheimer's Disease (AD) or Mild Cognitive Impairs (MCI), the accurate identification of patients from normal control persons (NCs) is critical. Recently, numerous researches have been undertaken on the identification of AD based on neuroimaging data, including images with radiographs and algorithms for master learning. In the previous decade, these techniques were also used slowly to differentiate AD a

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Publication Date
Sun Aug 13 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Fixation of Efficient Method for Separation and Analysis of Alkyl Al koxy Silan Compounds by Gas Chromatography
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       Modification of gas chromatographic technique for the separation and determination of methyl ethoy silane compounds which were synthesized by the addition of absolute ethanol to methyl chlorosilane compounds have been elaborated experimentally.  The addition of absolute dry ethanol to methyl chlorosilane compounds in the presence of a dry stream of nitrogen gas led to sweep out the liberated HCl gas. This method was found to be the suitable method for the preparation of methyl ethoxy silane compounds. The optimum parameter selected after careful and precise studies was between 20 – 30 ml \ min to carrieir gas flow rate, while applied temperatures of detector and injection part were 250 Â

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Publication Date
Tue Feb 28 2023
Journal Name
Iraqi Journal Of Science
Morphotectonic Analysis of Wadi Al-Batin Alluvial Fan, South of Iraq, Using Remote Sensing and GIS Techniques
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This research aimed to know the tectonic activity of the Wadi Al-Batin alluvial fan using hydrological and morphotectonic analyses. Wadi Al-Batin alluvial fan is deposited from Wadi Al-Rimah in Saudi Arabia, which extended to Iraqi and Kuwait international boundaries. The longitudinal and transverse faults that characterize this region were common. The Abu- Jir-Euphrates faults have a significant impact on the region. The faults zone consists of several NW- SE trending faults running from the Rutba in western Iraq to the south along the Euphrates through Kuwait and meeting the Al-Batin fault to the Jal Al-Zor fault. The Hydromorphometric analysis of the present fan shows five watersheds having asymmetry shapes, more elongated and activi

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Publication Date
Thu Apr 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Application of GIS and Remote Sensing Techniques for Hydromorphometric Analysis of Wadi Al-Mohammadi Basin, Western Iraq
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Hydromorphometric analysis as a method is considered one of the most reliable and used methods in solving hydrological problems. Where it is possible to know the volume of runoff and the rest of the elements that enter into the water balance. Geographical Information System and Remote Sensing is the technique that used the hydro-morphometric analysis of the Wadi Al-Mohammadi basin. Wadi Al-Mohammadi, located in the Western Desert, is one of the main valleys that flow into the Euphrates River. It is considered an important basin, because of its many characteristics, including its relatively large area and the amount of water drained through, which is used mainly in watering livestock and agriculture, in addition to industrial purposes suc

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Publication Date
Sun Jun 11 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The First Record of Three Monogenean Species of Gyrodactylus in Iraq from Gills of Some Fishes in Tigris River, Al-Shawwaka Region, Baghdad Province
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    Three monogenean species of the genus Gyrodactylus viz. G. cotti Roman, 1956 on gills of Planiliza abu, G. mikailovi Ergens & Ibragimov, 1976 on gills of Chondrostoma regium and G. prostae Ergens, 1963 on gills of Alburnus caeruleus were recorded from Tigris river at Al-Shawwaka region, Baghdad. The description and measurements of these parasites as well as their illustrations where given. All these parasites are recorded here for the first time in Iraq.  
 

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Publication Date
Sat Nov 10 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Prevalence of Anxiety and Depression Among the Iraqi Repatriated Prisoners of the Iran-Iraq War, 1980-1988
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Objective: To find out the prevalence of anxiety and depression among Iraqi repatriated prisoners of Iran-Iraq war
(IRPOWs), and the relationship with some variables.
Methodology: A descriptive study was carried out from Oct. 18th, 2009 through Jan. 10th, 2010. A Snowball
sampling as a non-probability sampling technique was used to recruit 92 repatriates who had visited Ministry of
Human Rights. An instrument was constructed for this purpose. The constructed instrument consisted of six
demographic characteristics, and fourteen items to measure the level of anxiety and depression in prisoners of
war (POWs). Data were collected with using the constructed instrument and the process of the interview as means
for data col

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