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Preparation and Evaluation of Rebamipide Film using Casting Technique for Local Action
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Abstract

The aim of this study was to prepare rebamipide ocular inserts in order to extend its release on the ocular surface for dry eye treatment. Solubility study was applied to the drug with or without l-arginine using different solvents. Solvent casting technique was used to prepare the inserts; l-arginine was used to solubilize the drug, hydroxypropyl methylcellulose grades (E5 and K15M) and poly ethylene glycol 200 were used as excipients. The inserts were evaluated for their physical and mechanical properties, moisture loss% and absorption %, surface pH, and in-vitro drug release. The use l-arginine exhibited an enhancement of rebamipide solubility in both deionized water and phosphate buffer (pH 7.4) by approximately 250 times and 3 times, respectively. The formulations showed uniform weight and thickness except for F1, and all showed uniform drug content. The absence of plasticizer in F1 caused haziness in its appearance and brittleness of the inserts. F3 which contain hydroxypropyl methylcellulose K15M showed good physical and mechanical properties thus was selected for in vitro release and was compared to the marketed brand Mucosta® suspension eye drop; F3 showed significant enhancement in extending the release of rebamipide compared to the reference marketed brand.

Keywords: Rebamipide, L-arginine, Ocular insert, Solvent casting technique

 

 

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Publication Date
Fri Jun 09 2023
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Evaluation of the Anti-inflammatory of Leucaena leucocephala extracts in Experimental Rats.
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Thu Jul 01 2021
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Evaluation of some biomarkers in diagnosis of bacterial bloodstream infection in children
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Photodynamic therapy in the management of actinic keratosis: Retrospective evaluation of outcome
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Evaluation of nurses’ knowledge toward pain management of leukemic child under chemotherapy
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HISTOLOGICAL EVALUATION OF THE WOUND HEALING ACTIVITY OF ALLIUM AMPELOPRASUM METHANOL EXTRACT
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Sat Sep 30 2023
Journal Name
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The reflection of environmental quality costs on the evaluation of environmental performance
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Sun Dec 09 2018
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Publication Date
Wed Jan 01 2020
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Evaluation of some immunological aspects in iraqi pregnant women with toxoplasmosis
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Publication Date
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