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Evaluation of Analgesic Activity of Newly Synthesized Phthalyl- tyrosyl-glycin Sodium

Alteration in the backbone structure of the endogenously released opioid peptides Leu5/Met5 enkephalins may result in compounds having comparable profile of pharmacological activity but with different physicochemical properties and side effects. Phthalyl amino acid and phthalyl esters are among the derivatives that have been synthesized and evaluated for their antibacterial and antifungal activities.This study was conducted to evaluate the possible analgesic activity of phthalyl-tyrosyl-glycin sodium that has been recently synthesized by our team.The study was carried out on 24 albino mice using hot plate method. The animals were allocated in to three groups; the first group received saline and represent a control group; the second group received morphine HCl as a standard drug; and the third group received phthalyl-tyrosyl-glycin sodium. The onset with which the animal lift his forearm and the number of jumps per 25 seconds were recorded for each group.

   The results of this study showed that phthalyl-tyrosyl-glycin sodium resulted in significant improvement (P<0.05) in analgesia score as well as significant delay in the onset of induced hyperalgesia in comparison to saline-treated group, and in comparison to morphine HCl, no significant difference (P>0.05) was observed in analgesia score but with significant delay in induced hyperalgesia.The results obtained in this study provide experimental evidences for the effectiveness of the prepared compound as analgesic with comparable effect to that of morphine.

Key words: Phthalyl-tyrosyl-glycin sodium, phthalyl group, analgesia

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Publication Date
Tue Feb 28 2023
Journal Name
Iraqi Journal Of Science
The Effectiveness of using the Biofilter made from Bidara (Sidr) to reduce the negative effects of Mice Cigarette Smoke

       This study aims to determine the effect of exposure to cigarette smoke with a biofilter of bidara leaf powder on the histology of the liver, lungs and blood viscosity of mice. This test was carried out for 28 days by giving cigarette smoke with a biofilter of bidara leaf powder and observing the histology of the liver, lungs and blood viscosity. The results showed that exposure to cigarette smoke with a biofilter of bidara leaf powder was very effective in reducing damage to the liver and lungs of mice, and also very effective in reducing blood viscosity as in normal mice blood viscosity. The use of Bidara leaf powder biofilter can affect the histology of the liver, lungs and blood viscosity in mice. Bidara leaf powder biofi

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Publication Date
Tue May 30 2023
Journal Name
Iraqi Journal Of Science
Ground State Structure of Helium and Phosphorus Isotopes using the Radial Wave Functions of Harmonic-Oscillator and Hulthen Potentials

     The ground state density distributions and electron scattering Coulomb form factors of Helium (4,6,8He) and Phosphorate (27,31P) isotopes are investigated in the framework of nuclear shell model. For stable (4He) and (31P) nuclei, the core and valence parts are studied through Harmonic-oscillator (HO) and Hulthen potentials. Correspondingly, for exotic (6,8He) and (27P) nuclei, the HO potential is applied to the core parts only, while the Hulthen potential is applied to valence parts. The parameters for HO and Hulthen are chosen to reproduce the available experimental size radii for all nuclei under study. Finally, the CO component of electron scattering charge fo

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Publication Date
Thu Jun 01 2023
Journal Name
Baghdad Science Journal
Design and study the effect of inner bore diameter on the magnetic and optical properties of the unipolar lens

    Many designs have been suggested for unipolar magnetic lenses based on changing the width of the inner bore and fixing the other geometrical parameters of the lens to improve the performance of unipolar magnetic lenses. The investigation of a study of each design included the calculation of its axial magnetic field the magnetization of the lens in addition to the magnetic flux density using the Finite Element Method (FEM) the Magnetic Electron Lenses Operation (MELOP) program version 1 at three different values of current density (6,4,2 A/mm2). As a result, the clearest values and behaviors were obtained at current density (2 A/mm2). it was found that the best magnetizing properties, the high

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Publication Date
Wed Oct 20 2021
Journal Name
Journal Of Engineering Research
Effect of several patterns of floating stone columns on the bearing capacity and porewater pressure in saturated soft soil

One of the common geotechnical problems is the construction on soft soil and the improvement of its geotechnical properties to meet the design requirements. A stone column is one of the well-known techniques used to improve the geotechnical properties of soft soils. Sometimes thick layers of soft soil imposed the designer to use floating stone columns for improvement of such soil; in this case, the designer will be lost the end bearing of the stone column. In this study, the effects of several patterns of floating stone columns distribution under footing on the bearing capacity of soil and the distribution of excess porewater pressure are investigated. The soft soil used in this study has a very low undrained shear strength (cu) of

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Publication Date
Thu Feb 16 1995
Journal Name
. مجلة العلوم الزراعية العراقية 26 (1), 84-87
Publication Date
Sat Jan 21 2023
Journal Name
Indian Journal Of Health Sciences And Biomedical Research (kleu)
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Publication Date
Sun Dec 30 2012
Journal Name
Al-kindy College Medical Journal
The Necessity of Teaching Diabetic Patients the Correct way of Insulin Administration: A Clinical Trial to Improve Glycemic Control

Background: It is important to achieve good glycemic control to avoid long-term diabetic complications. It has been largely debated about the role of correct way of insulin administration to get the desired glycemic control.
Objective: To evaluate the effect of teaching diabetic patients who are on insulin therapy the correct way of injecting insulin and its effect on glycemic control.
Methods: A non randomized clinical trial with 820 diabetic patients on insulin therapy on whom A1 c estimation was performed before and after three months of teaching them the right injection technique.
Results : Sixty seven patients (8.17%) had A1 c 6.5% before they were enrolled in the study while the majority (753 patents, 91.82%) had A1 c 6.5%

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Publication Date
Sat Dec 02 2023
Journal Name
Bulletin Of The Iraq Natural History Museum
MORPHOLOGICAL AND MOLECULAR STUDIES OF KAIS KINGFISH CYPRINION KAIS HECKEL, 1843 (PISCIES, CYPRINIFORMES, CYPRINIDAE) FROM THE MIDDLE OF IRAQ

Cyprinidae species are the most abundant and widely distributed fish species in the inland waters of Iraq. Cyprinids are complex species, and it is difficult to identify them on the basis of morphology. Thus, the morphological characteristics must be achieved and confirmed by molecular analysis. Twenty specimens of Cyprinion kais Heckel, 1843 (Piscies, Cypriniformes, Cyprinidae) were collected from two localities at Tigris River in the middle of Iraq: five specimens from Al-Tharthar Lake, Saladin Province, and 15 specimens from Al- Zubaydiyah sub-district, Wasit Province

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Publication Date
Tue Feb 28 2023
Journal Name
Iraqi Journal Of Science
The Effect of Temporal Resolution of Climatic Factors on Agriculture Degradation in Southern Baghdad by Applying Remote Sensing Data

       The climate changes had been recognized as one of the major factors responsible for land degradation, which has a significant impact on diverse aspects. The present study aims to estimate how the climate change can influence land degradation in the south areas of Baghdad province (Al-Rasheed, Al-Mahmudiyah, Al-Yusufiyah, Al-Madaen, and Al-Latifiyah). The Satellite Landsat-8 OLI and satellite Landsat-5 TM sensor imagery were used to extent land degradation for the period (2010-2019). ArcGIS V.10.4 was applied to manage and analysis the satellite image dataset, including the use of climate factors data from the European Center for Climate Forecasts (ECMWF) by reanalyzes and extraction datasets. To achieve work objectives, many

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Publication Date
Wed Nov 24 2021
Journal Name
Iraqi Journal Of Science
Geochemistry and Depositional Conditions of the Cretaceous Oceanic Red Beds (CORBs) within the Shiranish Formation in North of Iraq

Upper Cretaceous Oceanic Red Beds (CORBs) are pelagic sediment deposits that deposited in the Upper Cretaceous basin, with widespread in part of the world as well as in Iraq. This research investigates the deposition of cyclic marl and marly limestone CORBs of six selected sections at the active southern margin of the Tethys during the Late Campanian - Maastrichtian with petrography, microfacies, and depositional environment.
The measurement of carbonate content (CaCO3 %) in the rocks, 180 samples of all the geological sections were studied twice for each sample and the average readings were taken.
This examination proved the following major oxides wt. % concentrations domination SiO2, CaO, Al2 O3 and Fe2O3 with average values of 3

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