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Hepatoprotective Effect of Echinops tenuisectus (Compositae) on CCl4 Induced Hepatic Damage in Rats

Flavonoids are known to play a vital role in the management of various liver disorders.They are a large family of compounds synthesized by plants; they belong to a group of natural substances with variable phenolic structures. In this study we aim to scan the types of flavonoids in a newly studied, wild Iraqi plant named Echinops tenuisectus of Compositae family. The medicinal importance of flavonoids on one hand, and the absence of any phytochemical investigation on tenuisectus species of Echinops genus on the other hand, acquired this study itۥs importance. Three flavonoids were identified in the seed,s extract of this plant (Silymarin, Rutin, Quercetin ) by two chromatographic methods, first Thin layer chromatography (TLC) using TLC ready made GF254 plates, UV detector at 254 nm, and two different solvent systems in which the Rf value of the standards (Silymarine, Rutin, Quercetin) matched with the Rf value of the Silymarin, Rutin and Quercetin found in the plant seed٫s extract. High pressure liquid chromatography (HPLC) was the other chromatographic method that used to identify the presence of these flavonoids in the plant seed. The plant seed ۥs aqueous extract was evaluated for its efficacy in rats by inducing hepatotoxicity with CCl4.Single oral dose of 250mg/kg of Seeds Extract was given to ratۥs for 7 days. Serum activities of transaminases (ALT and AST) were used as the biochemical marker of hepatotoxicity. Histopathological changes in ratُُs liver section were also examined. The results of the study indicated that, the pretreatment of rats with Echinops extract before the hepatotoxins agent (CCl4) offered a hepato- protective action.

Key words: Echinops, Flavonoids

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Publication Date
Thu Nov 08 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
An Epidemiological Approach of Hydrocephaly Parameters in Duhok Province

Objective(s): This study was conducted to deal with the importance and effect of various variables which might
have influence in hydrocephaly occurrence.
Methodology: A retrospective design was performed and continued for 4 months. It included 89 nonrandomized
consecutive samples collected from the Early Detection of Childhood Disabilities Center (E.D.C.D.C.)
Duhok. The population involved was the entire cases of both sexes that attended the centre during the period from
1
st.Jan, 1998 to 30th. Dec. 2008 with final diagnosis of hydrocephaly. Patients’ records from the centre were used to
collect data.
Results: Hydrocephaly has been recognized as a public health problem in Duhok province, Iraqi Kurdistan region,<

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Publication Date
Mon Nov 19 2018
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Study of Two Types Finite Graphs in KU-Semigroups

      In this Ë‘work, we present theË‘ notion of the Ë‘graph for a KU-semigroup  as theË‘undirected simple graphË‘ with the vertices are the elementsË‘ of  and weË‘Ë‘study the Ë‘graph ofË‘ equivalence classesË‘ofË‘  which is determinedË‘ by theË‘ definition equivalenceË‘ relation ofË‘ these verticesË‘, andË‘ then some related Ë‘properties areË‘ given. Several examples are presented and some theorems are proved. ByË‘ usingË‘ the definitionË‘ ofË‘ isomorphicË‘ graph, Ë‘we showË‘ thatË‘ the graphË‘ of equivalence Ë‘classes Ë‘and the Ë‘graphË‘of Ë‘a KU-semigroup Ë‘  areË‘ theË‘ sameË‘,

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Publication Date
Sat Jun 27 2020
Journal Name
Iraqi Journal Of Science
Application of Probit Analysis in Studying the Allelopathy Phenomenon

   Probit analysis is a type of regression used to analyze the relationship between a stimulus and the quantal response. Allelopathy refers to direct or indirect negative or positive effects of one plant on another through the release of chemical compounds into the environment. This study was carried out to apply probit analysis in investigating the allelopathic effects of the leaves aqueous extracts of apple of Sodom [Calotropis procera (Aiton) W.T.] on the inhibition of seed germination of African rattlebox (Crotalaria saltiana Andr.). A laboratory experiments were carried out at the Faculty of Agricultural Sciences, University of Gezira, Sudan in season 2014/15. Ten concentrations (2.3, 4.6

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Publication Date
Thu Jun 25 2020
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Formulation and In-vitro Evaluation of Itraconazole Floating Microparticles

Itraconazole (ITZ) is an antifungal drug (BCSII) used for the treatment of local and systemic fungal infections. Furthermore, ITZ used as an antifungal prophylaxis for immunocompromised patients.

The objective of the study is to overcome the two problems of low and pH dependent solubility of ITZ by its preparation as floating microparticles.

Firstly, pH-dependent floating microparticles were prepared using oil in water solvent evaporation method, from which the best one (F7) selected as a best pH-dependent formula with composition of   ITZ (200mg),EC (800mg), HPMC 15cps (200mg) and safflower oil (2ml) .Then, F7 was compared with the selected Relatively pH-independent ITZ floating microparticles formula  wit

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Publication Date
Tue Dec 29 2020
Journal Name
Iraqi Journal Of Science
Biomarker Significance of Interleukin-18 in Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) represents a group of multifactorial autoinflammatory arthritis diseases. A dysregulated production of pro-inflammatory cytokines is proposed to have a role in the pathogenesis of the disease. Interleukin-18 (IL-18) is one of these pro-inflammatory cytokines. Therefore, this study aimed to define the role of IL-18 in the pathogenesis of JIA. Accordingly, the serum level of IL-18 was determined in 59 Iraqi JIA patients and 58 matched controls. The results revealed a significantly increased median of IL-18 in the patients as compared to the control. A similar increased level was observed in subgroups of patients characterized according to gender, seropositivity for C-reactive protein and rheumatoid facto

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Publication Date
Fri Aug 28 2020
Journal Name
Iraqi Journal Of Science
The hydrochemistry of Tigris River in Baghdad city, Iraq

The primary objective of this study was to investigate the current status of water-quality conditions and assessment it in the Tigris River, Baghdad, Iraq, and to determine how those conditions are changing over time of pollution if any. A series of Hydrochemical tests were carried out to ascertain the influence of major Cations and Anions, Total Dissolved Solids (TDS), Electrical Conductivity (EC) and Potential of hydrogen (pH) on the quality of water. To assess the environmental pollution of the study area: 34 water samples were collected along Tigris River from north to south Baghdad City; 17 on January 2019 and 17 on April 2019. Result of the test were compared with the World Health Organization standards, and showed that all the

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Aesthetic discourse in the significance of commercial advertisement designs

The current research is concerned with the study of (aesthetic discourse in the significance of commercial advertisement designs), according to a knowledge structure defined by function and creativity, and the main goal is to interpret the reality of forms, their various sources, their essence, meanings, formal relationships, and design ideas in order to achieve the visual goal as a typographic achievement. It arises through the designer’s internal mental intuition to produce shapes based on subjective feelings that refer his preconceptions about those shapes with his feelings to creative formations. Aesthetic discourse is produced from the mind depending on the various symbolic, psychological and social functions, production methods,

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Publication Date
Fri Sep 02 2022
Journal Name
Journal Of Legal Sciences
The criterion of dependency in civil law : Comparative Study

The dependency means the existence of a subordinate to whom a dependant is attached and extends his judgment to him, being and nothing, Dependency has elements that must be available to achieve the dependency relationship, which is the existence of dependent and master with a link join the first to the second, and dependency may be between two obligations, between two rights, or between two things, And we suggested the nature of the obligation as a criterion for verifying the existence of dependency , Which requires the subordinate's attachment to the master with a permanent fateful bond so that one of them does not separate from the other, for the existence of the follower is associated with the existence of the master and it does not e

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Publication Date
Mon Jan 28 2019
Journal Name
Journal Of The College Of Education For Women
Parity of Human Values in the Islamic Thought Research

Human values are the most important concepts that the interest of society has to relay on these conceptual values. Any society will not be stabilized unless adheres to the right principles and values, all nations need such principles and values to stabilize. If any society doesn’t implement the human values that monotheistic religions urges equality between human, the far the society from the religious principles, the less there would be valence between human. The valence is urgent necessity in the current time. The far people get away from values and principles, the more they lose their freedom and dignity, therefore individual has to live with dignity and respect through the adherence to these values and principles. Apparently, equal

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Publication Date
Wed Feb 01 2023
Journal Name
Journal Of Engineering
Procurement Management of Power Plants Construction Projects in Iraq

The government of Iraq states that despite the massive amounts invested in the power generating sector, the country has been plagued by power outages for more than three decades; One of the most common sources of the problem and significant impact on the waste of public funds in contractual processes. The Ministry of Planning issued the sectorial
specialized standard bidding documents (SSBD) of Design, Supply, and Installation of the Electromechanical Works (DSIoEW), which is primarily designed to support the Ministry of Electricity (MoE) by developing economic projects to improve the contractual process that led to raisings Iraqi electricity generation field. The research evaluates the impact of
applying the SSBD-DSIoEW for

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