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Study of the Protective Effects of Benfotiamine Against CCl4-Induced Hepatotoxicity in Rats
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Liver is considered as the first target for the toxic effects of toxins and other xenobiotics, and this can be attributed to its role as a site which receive all absorbed xenobiotics from the gastrointestinal tract and its role as a major site for biotransformation of xenobiotics. The present study was designed to evaluate the possible hepatoprotective effect of benfotiamine against CCl4-induced hepatotoxicity in rats. The study was conducted on 48 male albino rats; the animals were allocated into 8 groups (6 rats in each group) and treated as follow: 4 groups treated with oral doses of either normal saline, benfotiamine (100 mg/kg), thiamine (100 mg/kg), N-acetylcystein (400 mg/kg) only without induction of hepatic damage. The other 4 groups were treated as indicated previously with induction of hepatic damage with CCl4; at the end of treatment period, rats were scarified, blood samples obtained and livers excised for the assessment of the oxidative stress parameters (MDA and GSH), cholesterol and triglycerides levels. Additionally, serum levels of total bilirubin, albumin, total protein and the activities of ALT, AST and ALP enzymes were evaluated before and after treatment with benfotiamine. Tissue sections were prepared for evaluation of histopathological changes. The results indicated that benfotiamine has the ability to protect hepatic tissue against the toxicity induced by CCl4, revealed through reduction of serum levels of TSB and liver enzymes, decrease in the hepatic tissue MDA levels and elevation of GSH there. Histological evaluation of tissue sections prepared for this purpose confirmed the previous finding. In conclusion, benfotiamine is capable to protect liver tissue against CCl4-induced toxicity in rats more than thiamine.

Key words: Benfotiamine, CCl4, Hepatotoxicity

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Publication Date
Mon Jul 01 2013
Journal Name
Biochemical And Biophysical Research Communications
Suppression of T cell-induced osteoclast formation
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Inhibition of T cell derived cytokine production could help suppress osteoclast differentiation in inflammatory skeletal disorders. Bisphosphonates are typically prescribed to prevent inflammatory bone loss but are not tolerated by all patients and are associated with an increased risk of osteonecrosis of the jaw. In light of this other anti-resorptives such as phytoestrogens are being considered. However the effect of phytoestrogens on T cell-induced osteoclast formation is unclear. The effect of genistein and coumestrol on activated T cell-induced osteoclastogenesis and cytokine production was therefore examined. Concentrations of genistein and coumestrol (10−7 M) previously shown to directly inhibit osteoclast formation also suppressed

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Publication Date
Fri Oct 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Spectroscopic Diagnostic of Laser-Induced Zn Plasma
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The sample's physical characteristics and laser parameters impact the generation and characterization of Laser-Induced Plasma (LIP), which is a relevant phenomenon in many applications. We investigated the effect of laser energy on laser-induced Zn plasma characterization in this study. A Zn plasma with a repeating frequency of 6 Hz, a first wavelength of 1064 nm, a pulse duration of 10 ns, and a laser energy range of 300 mJ to 500 mJ was created using a Q-switched ND: YAG laser. The basic plasma properties, such as electron temperature and density, were estimated using optical emission spectroscopy (OES). The electrons' temperature was measured by the Boltzmann plot method, and the value of the electrons' temperature ranged from 1.6 eV

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Publication Date
Sun Apr 02 2006
Journal Name
Journal Of The Faculty Of Medicine Baghdad
exercise induced growth hormone and the effect of age and oxidative stress parameters in Iraqi subjects
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Background:

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Anti-bacterial Properties of Melatonin against Mycobacterium Tuberculosis in Vitro
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         57 isolates of Mycobacterium tuberculosis and Mycobacterium bovis were identified; they were isolated from different clinical sources which included sputum, bronchial wash, abscess, pleural fluid, gastric fluid, eye fluid, and CSF, also urine and ear swab. This investigation was carried out on 198 patient attended National Reference Laboratory for T.B during September 2009. Also the study declared that the ratio of separation of this bacterium from male was (67.6%) and it’s higher than the ratio of separation this bacterium from females which was (32.3%). The susceptibility of Mycobacterium tuberculosis to melatonin was evaluated. Many concentrati

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Publication Date
Tue Mar 26 2019
Journal Name
Iraqi Journal Of Science
Evaluation of the Activity of the Diatom Navicula Incerta Cultivated in Different Environments Against Several Species of Pathogenic Bacteria
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Diatoms are considered a potentially new and valuable source of biologically active compounds including those with antimicrobial properties; so, this study was conducted to evaluate the antibacterial activity of Navicula incerta. The diatom was isolated from the salt water of Sawa Lake, southern of Iraq, it was cultivated in salt water then was adapted and cultivated in freshwater environment; the harvested and dried biomass was extracted, and the antibacterial activity of each extract was evaluated against several species of pathogenic bacteria. The chemical constituents of the extracts were also analyzed using Gas chromatography/Mass spectrometry technique. Generally, the result showed that fresh water extract of N. incert

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Publication Date
Tue Apr 01 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Retinal effects of Sildenafil in diabetic patients
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Background
Sildenafil has been used in the treatment of erectile dysfunction (ED). However it has the disadvantage of many visual disturbances. The aim of this work is to study the effect
of sildenafil on diabetic patients which might have ocular problems due to diabetes mellitus.
Materials and Methods:
A total of 30 subjects were enrolled in the study, they were divided into two groups. The control group consisted of 10 healthy subjects but complaining of ED only and the
other (20 patients) had diabetes mellitus and ED as well. All subjects had ocular tests done before and after sildenafil intake. It was obvious that sildenafil changed visual tests from totally normal for controls, before tre

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Publication Date
Sat Jun 08 2024
Journal Name
Obstetrics And Gynaecology Forum
Biochemical and Immunological responses to use dexamethasone in rats
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This study was conducted to determine the side effects of dexamethasone n some physiological and immunological criteria, which included, Measuring sugar level, liver (ALT, AST , LDH, Total protein) and kidney function (urea, createnine), total and differential count of W.B.C,CRP, TNF-α ,IL6,IL10. thirty rats were divided into two groups (15\ rat). G1: This group was considered negative control injection with normal saline, G2: This group was injected with 2 mg\kg dexamethasone. The results showed a significant increase in the level of enzymesALT, AST and sugar levels and decreased level of total protein in the group treated with the drug, also showed, a significant decrease in the total number of W.B.C an

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Publication Date
Wed May 24 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Effects of the Zinc on Activity of Immune System in Male Albino Mice
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   Effect of zinc chloride on the immune  functions was studied in male albino mice aged 6-7 weeks. It was administrated orally (1ml) in three concentrations (0.5ppm, 1ppm, 2ppm) for 9 days.         The results showed that the first concentration was not effective comparing with control while the second concentration increased the enhancement of immune system and the cell third one killed the mice 6 hours post administration, so we can conclude that the high dose of ZnCl2 could be harmful for all metabolism.

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Publication Date
Sun Jan 26 2020
Journal Name
Iraqi Journal Of Science
Evaluation of the Toxicological Effects of Zinc Oxide Nanoparticles in Albino Male Mice
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The acute and sub chronic toxicity effects of 25.16 nm intraperitoneally- injected zinc oxide nanoparticles (ZnO NPs) were evaluated. Albino male mice were exposed to three different doses (25, 50 ,and 100 mg/kg ), depending on the value of calculated LD50, for 2 and 4 weeks . Considerable changes in organ indexes were shown with a good relevance to the illustrated histopathological effects which ranged from multiple hemorrhagic foci in liver, mild swelling and dilatation in kidney tubules, thickening of intestinal villi, moderate interstitial pneumonia, especially with the high dose , and sever necrosis of seminiferous tubules in testes of all studied groups. Significant changes in both hematological and biochemical parameters as well a

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Publication Date
Fri Feb 08 2019
Journal Name
Journal Of The College Of Education For Women
The changes in the thickness of 1000 – 500 MB and it effects the climate of Iraq
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This research paper is about synoptic climate specifically with in the upper air layers
using upper air layers maps analysis which are maps of thickness for the level 1000 – 500
MB, that their high average ranges between 100 – 5600 M above surface. This research paper
focuses on studying special and temporal variations of the atmosphere thickness above Iraqaccording
to this study, it is concluded that atmosphere thickness above Iraq increases
towards south with an average of 100 M as compared with north of Iraq. Regarding the
temporal variations, it is concluded that atmosphere thickness during hot months. In July, for
example, the atmosphere thickness becomes thicker than in January with an average of
(250)M

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