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Concentration-Dependant Antioxidant Activity of Pentoxifylline in Nitrite-induced Hemoglobin Oxidation Model
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         Free radical formation in heme proteins is recognized as a factor in mediating the toxicity of many chemicals. The present study was designed to evaluate the dose-response relationship of the free radical scavenging properties of pentoxifylline in nitrite-induced Hb oxidation. Different concentrations of pentoxifylline were added at different time intervals of Hb oxidation in erythrocytes lysate, and formation of methemoglobin (MetHb) was monitored spectrophotometrically. The results showed that in this model, pentoxifylline successfully attenuates Hb oxidation after challenge with sodium nitrite; this protective effect was found to be not related to the catalytic stage of Hb oxidation, though such effect was reported to be more prominent when the compound was at the same time of induction of Hb oxidation with nitrite. In conclusion, pentoxifylline can effectively, in concentration-dependent pattern, attenuate sodium nitrite-induced Hb oxidation in vitro.

Key words: pentoxifylline, radical scavenging, hemoglobin oxidation

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Publication Date
Sat Jun 19 2021
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Protective Effects of Safranal Against Selenite-Induced Cataract in Rats
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         Cataract, which is the opacity inside clear ocular lens of eye, result in the scattering of visible light as it passes via the lens and consequently deterioration in optical image. The aim of the present study was to investigate whether safranal, an active constituent of Crocus sativus L. stigmas, has a protective effect on the cataract in the rat's pups. The animals were randomly divided into five groups, each of which consisted of 7 rat pups. Group I served as normal control (vehicle administration). For testing cataract induction, animals of Groups II, III, and IV were administered a single subcutaneous injection of sodium selenite on postpartum day 12. After sodium selenite intoxicatio

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Publication Date
Wed Nov 01 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Protective Effect of Cafestol on Doxorubicin-induced Genotoxicity in Rats
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Doxorubicin is an efficient antineoplastic agent that has a broad antitumour spectrum; however, its genotoxic adverse effects on normal cells can be produced through oxidative damage, and this limits its clinical application. Cafestol is a naturally-occurring diterpene in unfiltered coffee with noteworthy antioxidant, antimutagenic and anti-inflammatory activities.

The present study aimed to investigate the possible protective effect of cafestol against doxorubicin-induced chromosomal and DNA damage in rat bone marrow cells. Wistar

Albino rats of both sexes were administered cafestol (5mg/kg body weight once

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Publication Date
Wed May 31 2017
Journal Name
Iraqi Journal Of Market Research And Consumer Protection
THE EFFECT OF ALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS IN ALLOXAN INDUCED DIABETIC RATS.: THE EFFECT OF ALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS IN ALLOXAN INDUCED DIABETIC RATS.
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Active compounds were extracted from Anethum gravoelens to produce safety vegetable treat for diabetic, the results showed that alcoholic extract of Anethum gravoelens contain Alkaloid, glycosides, phenols, resins, saponins, coumarins, flavonoide, terpenes, steroids and volatile oils. after that it was studied the effect of alcoholic extract at dose 50, 100 mg/kg of body weight in reduced glucose level in serum of diabetic rats induced by alloxan, after the end of experiment for period 30 days the rats fasting 12 hours to measure the level of glucose in serum, the result showed asignificant decrease in serum glucose level of rats treated with extract in comparison with positive group (alloxan), So biochemical tests showed significant dec

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Publication Date
Wed Jul 20 2022
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Measuring the Concentration of Radon Gas in Book Stores in Primary Schools in Diyala Governorate
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  In this research, the concentration of radon gas was calculated in the book store rooms of schools in Diyala Governorate, it was calculated by Solid State Nuclear Track Detectors (SSNTDS) when the detector (CR-39) was used, the detector was placed and suspended at a distance of 160 cm from the surface of the earth, and the detector was exposed for 30 days to record alpha tracks. The results of radon concentration showed that the highest concentration percentage was found in (Eishtar) school, which was equal to (84.896) Bq/m3, while the lowest value was recorded in (Habhib) school, which was equal to (11.242) Bq/m3, where the concentration rate was equal to (28.158) Bq/m3. When we compared our results w

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Publication Date
Thu Jul 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Cr (III), Fe (III), Co (II) and Cu(II)Metal ions complexes with azo compound derived from 2-hydroxy quinolin synthesis, characterization, thermal study and antioxidant activity
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Azo-ligand-(HL)([4-((2-hydroxyquinolin-3-yl)diazenyl)-N-(5-methylisoxazol-3-yl)benzenesulfonamide] ) ,  (2- hydroxy quinolin  derivative),reacts with the next metal ions (Cr (III), Fe (III),Co (II) and Cu(II))  forming stable complexes with unique geometries such as(tetrahedral for bothCo (II) and  Cu (II), octahedral for both Cr (III) and Fe (III)). The creation of such complexes was detected by employing spectroscopic means involving ultraviolet-visible which proved the obtained geometries, Fourier transfer proved the involvement of coordinated water molecule in all complexes besides the pyrolysis (TGA & DSC) studies proved the coordination of water residues with metal ions inside the coordination sphere as well as chlorine ato

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Publication Date
Sun Sep 30 2007
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Concentration of Hydrogen Peroxide by Batch Distillation Column
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An investigation was conducted to study the concentration of hydrogen peroxide by vacuum distillation. The effect of the process variables (such as vacuum pressure, reflux ratio, time of distillation, and packing height of the column used in the distillation process) on the concentration of hydrogen peroxide were investigated. During the third stage of distillation (95 wt.%) concentration was obtained.

Box-Wilson central composite rotatable design is used to design the experimental work for the mentioned variables. It was found that the concentration of hydrogen peroxide increases with Increasing vacuum pressure, decreasing reflux ratio, increasing the time of distillation and increasing the packing height.

The second ord

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Publication Date
Sat Jun 30 2001
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Kinetics of Sodium Tungstate Catalyzed Oxidation of Maleic Acid by Hydrogen Peroxide
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Publication Date
Mon Sep 16 2024
Journal Name
Plant Protection
In vitro investigation of phytochemical, antioxidant and antimicrobial activities of Harpagophytum procumbens seeds extracts
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Medicinal plants contain bioactive substances that are highly bioavailable in extracts or pure molecules, making them promising for therapeutic applications and precursors for chemo-pharmaceutical semi-synthesis. Harpagophytum procumbens (Devil’s Claw) is widely recognized as one of the most potent therapeutic herbs. This study aimed to extract seeds from H. procumbens using two types of solvents and to assess both qualitative and quantitative aspects of the extracts. The two extracts were evaluated for antibacterial and anti-biofilm activities using agar well diffusion assays against four bacterial isolates and two yeast isolates. Qualitative analysis identified the presence of alkaloids, flavonoids, tannins, saponins, and terpen

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Publication Date
Mon Sep 16 2024
Journal Name
Plant Protection
In vitro investigation of phytochemical, antioxidant and antimicrobial activities of Harpagophytum procumbens seeds extracts
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Medicinal plants contain bioactive substances that are highly bioavailable in extracts or pure molecules, making them promising for therapeutic applications and precursors for chemo-pharmaceutical semi-synthesis. Harpagophytum procumbens (Devil’s Claw) is widely recognized as one of the most potent therapeutic herbs. This study aimed to extract seeds from H. procumbens using two types of solvents and to assess both qualitative and quantitative aspects of the extracts. The two extracts were evaluated for antibacterial and anti-biofilm activities using agar well diffusion assays against four bacterial isolates and two yeast isolates. Qualitative analysis identified the presence of alkaloids, flavonoids, tannins, saponins, and terpen

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Publication Date
Sun Feb 10 2019
Journal Name
Iraqi Journal Of Physics
Radon concentration measurements in sludge of oil fields in North Oil Company (N.O.C.) of Iraq
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In this study the assessment radon concentration in sludge of Oil
Fields in North Oil Company (N.O.C.) of Iraq have been studied
using CR-39 solid–state nuclear track detector technique. A total of
34 samples selected from 12 oil stations in the company have been
placed in the dosimeters. The average radon concentration was found
to be 162.29 Bq/m3 which is fortunately lower than the standard
international limit. The potential alpha energy concentration and
annual effective dose have been calculated. A proportional
relationship between the annual effective dose and radon
concentration within the studied region has been certified.

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