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Synthesis of 5-Fluorouracil Derivatives as Possible Mutual Prodrugs with Meloxicam and Ibuprofen for Targeting Cancer Tissues
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In the present study, five derivatives have been designed to be synthesized as possible mutual prodrugs for 5-Fluorouracil (5-FU) and non steroidal anti-inflammatory drugs (NSAIDs) to selectively deliver the drugs into the cancer cells. The synthesis of the target compounds were accomplished following multistep reaction procedures, the chemical reaction followed up and the purity of the products were checked by TLC. The structure of the final compounds and their intermediates were confirmed by their melting points, infrared spectroscopy and elemental microanalysis, the hydrolysis of compound III was studied using HPLC technique. According to the results mentioned above, compounds (I−V) can be good candidates as possible mutual prodrugs of 5-FU and NSAIDs that can selectively deliver the parent drugs into the cancer cells by the effect of enzymes that elevated in tumor tissues compared with normal tissues.

Key wards: Anticancer, 5-Fluorouracil, NSAIDs, prodrug.

 

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Publication Date
Mon Sep 30 2019
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Certain Assessment of Using MWCNT Nps in Drilling Fluid to Mitigate Stick-Slip Problem during Drilling Operation System
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   Stick- slip is the continuous stopping& release of the Bit/BHA due to the irregular down-hole rotation prompted by the existing relationship between the friction torque and the torque applied from the surface to free the bit.

   Friction coefficient between BHA and wellbore is the main player of stick slip amount, which can be mitigated by support a good lubricators as additives in drilling mud.

   Mathematical (or empirical) solves should be done through adjusting all parameters which supposed to reduce stick- slip as low as possible using different models, one of the main parameters is drilling mud. As per Nanoparticles drilling fluid is a new technology that offers high performance

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Publication Date
Sun Oct 30 2022
Journal Name
Iraqi Journal Of Science
Measurement of Absorbed Dose in Water Using Co-60 gamma source Teletherapy Units According to IAEA Dosimetry Protocols
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      Modern radiotherapy facilities like 3-Dimensional conformal radio therapy (3DCRT), Intensity Modulated Radiotherapy (IMRT), were recently suggested in Co-60 machine with Multi-leaf Collimator (MLC). In this study, two reference chambers NE-2571#1205 and NE2581#537 were used for absolute dose measurement in Equinox accelerator. A comparison of dose measurement by two different IAEA protocols TRS-277 and TRS-398 has been studied. Analyzing TRS-398, a common shaped empirical formula was developed for the four Co-60 units of four Medical Colleges in Bangladesh with fitting parameters. It was found that an average discrepancy in the determination of absorbed dose in water among the two different protocols TRS-277 and TRS-398 were 1

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Publication Date
Tue Jan 30 2024
Journal Name
Iraqi Journal Of Science
The L^P-spaces of functions from the n-dimensional real space to the N-dimensional quaternionic space
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     In this paper, we introduce new definitions of the - spaces  namely the    - spaces  Here,  and  are natural numbers that are not necessarily equal, such that . The space  refers to the n-dimensional Euclidean space,  refers to the quaternions set and  refers to the N-dimensional quaternionic space. Furthermore, we establish and prove some properties of their elements. These elements are quaternion-valued N-vector functions defined on , and the  spaces  have never been introduced in this way before.

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Publication Date
Fri Jan 25 2019
Journal Name
Journal Of Al-qadisiyah For Computer Science And Mathematics Vol
Predicate the Ability of Extracorporeal Shock Wave Lithotripsy (ESWL) to treat the Kidney Stones by used Combined Classifier
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Extracorporeal Shock Wave Lithotripsy (ESWL) is the most commonplace remedy for kidney stone. Shock waves from outside the body frame are centered at a kidney stone inflicting the stone to fragment. The success of the (ESWL) treatment is based on some variables such as age, sex, stone quantity stone period and so on. Thus, the prediction the success of remedy by this method is so important for professionals to make a decision to continue using (ESWL) or tousing another remedy technique. In this study, a prediction system for (ESWL) treatment by used three techniques of mixing classifiers, which is Product Rule (PR), Neural Network (NN) and the proposed classifier called Nested Combined Classi

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Publication Date
Thu Jan 20 2022
Journal Name
Iraqi Journal Of Science
Enhance the delineation of masked structures in southern Iraq by applying the Biharmonic operator to their gravity field.
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The gravity field of southern Iraq shows steep gradient of regional trend. The gravity contours over the anticline structures in this area do not show the closure characteristic of these structures. The effect of lateral density variation for Hormuz Salt complicates the case in the area. Higher derivatives are one of the means that have been used to remove the effect of such regional gravity variations, which can easily mask significant structures. Biharmonic Operator is used to delineate these distort structures, follow their extent and at the same time distinguish new features. The Biharmonic operator manipulation has ability to suppress the effect of regional and enhance the local anomalies. The problem with higher derivatives operati

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Publication Date
Fri Dec 29 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Efficacy of Some Insect Growth Regulators (IGR) Against Jasmine White Fly Alearoclava Jasimini ( Homoptera: Aleyrodidae) on Citrus Tree
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The efficacy of five insect growth regulators has been tested against white fly larva Alearoclava jasimini on citrus tree orchards. Data from field tl'ia ls con finned that percent mortalities were 43.7, 33.9, 23.7, 20.8 and     12.3  for  Admiral ( I miL)  pyriproxefen, Nomol t  1 5 SC  (!milL) Teflubenzuren , Match 050 EC (  I milL ) Lufenuren , cascade I 0 F.C (

0.9mi/L) flufenoxaron, and Dimiline 10 EC ( I milL)  Difluben- zuron. The result indicated that Admiral and Nomolt have a continuous  effect for one month , so the treatment needs to be repeated for each four weeks. Also, Admiral and Nomolt effect against eggs hatching by 41. 3 % and

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    Publication Date
    Tue Sep 01 2020
    Journal Name
    Ain Shams Engineering Journal
    Estimating server utilization rate in single server queuing models using an approximate solution of stiff fluid flow model
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    Publication Date
    Sat May 01 2021
    Journal Name
    Key Engineering Materials
    Effect of Cold Plasma on the Levels Mineral Blood Components <i>In Vivo</i>
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    This study illustrates effect of cold plasma CAP on the mineral blood components in vivo. the mineral blood component (Ca, Na, Cl, K and Fe) are used. Floating Electrode-Dielectric Barrier Discharge (FE-DBD) system of probe diameter 4cm is used for this purpose, and variable voltage (0-20) kV and variable frequency (0-30) kHz, the output power was ranged from (10 - 70) W. the effect of cold atmospheric plasma on mineral blood is studied with different exposure durations (30,45,60) sec. As the plasma exposure duration increases, the calcium, potassium and iron components in the blood increased, while The sodium and chlorine elements decreased. These results give an indication of the cold plasma receptor to be used to treat many disea

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    Publication Date
    Mon Jun 01 2020
    Journal Name
    Iraqi Journal Of Physics
    Effect depositions parameters on the characteristics of Ni0.5Co0.5Fe2O4 nanocomposite films prepared by DC reactive magnetron Co-Sputtering technique
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    In this work, spinel ferrites (NiCoFe2O4) were prepared as thin films by dc reactive dual-magnetron co-sputtering technique. Effects of some operation parameters, such as inter-electrode distance, and preparation conditions such as mixing ratio of argon and oxygen in the gas mixture, on the structural and spectroscopic characteristics of the prepared samples were studied. For samples prepared at inter-electrode distance of 5 cm, only one functional group of OH- was observed in the FTIR spectra as all bands belonging to the metal-oxygen vibration were observed. Similarly, the XRD results showed that decreasing the pressure of oxygen in the gas mixture lead to grow more crystal planes in the samples prepare

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    Publication Date
    Tue Jun 15 2021
    Journal Name
    Al-academy
    Political Discourse in the Drawings of Faisal Laibi (Analytical Study): حيدر غضبان عبيد عليوي - سلام ادور يعقوب اللوس
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    The research aimed to study the political discourse in the drawings of Faisal Laibi, where it shed light on the discourse in the plastic field - concepts and applications, as well as the representations of discourse in the modern and contemporary plastic field, and to study the experience of Faisal Laibi and the uniqueness of his style in artistic performance. The site has collected more than (210 works) whose sources varied between the artist's website himself on the social network, the Internet, and the published paper publications. The researcher conducted an analysis of some of the drawings to achieve the research objectives. Among the most important results he reached:
    1. The political discourse of Faisal Laibi is to direct these

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