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Controlled Release Floating Matrix Tablet of Captopril
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The present study was done to prepare a gastroretentive floating tablet of captopril (CAP) which is an angiotensin converting enzyme inhibitor (ACE-inhibitor) used in the treatment of hypertension and heart failure. CAP is mainly absorbed from the proximal intestine and to a lesser extent from the stomach, also CAP stability decreases as the pH raised above 1.2 and this makes it a suitable candidate for floating dosage form.Effervescent floating tablets of CAP were prepared in order to prolong the gastric residence time and increase the bioavailability of the drug. The floating tablets of CAP were prepared by direct compression and wet granulation technique, using the polymer hydroxypropylmethylcellulose (HPMC) as the primary retarding polymer together with carboxymethylcellulose(CMC) ,ethyl cellulose(EC) and pectin as a secondary release modifying polymers in different ratios of (1:1, 3:1 and 9:1). Different formulation parameters were studied such as type of diluents, amount of effervescent agent, methods of preparation and their effects on buoyancy and the in vitro drug release profile as well as their physical characteristics. The wet granulation method shows a good flow and compressibility characteristics and a better dose uniformity in comparison with direct compression technique. Pectin together with HPMC in the ratio of 1:1 was found to meet the requirement for a good matrix formation and floating characteristics and the drug release was sufficiently sustained for 12 h with floating time >24h and floating lag time of 2 min. Kinetic modeling of the release data for the selected formula showed that the mechanism of drug release pattern follows anomalous or non –fickian diffusion.

Key words: Captopril, floating, matrix tablet, pectin.

 

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Publication Date
Wed Dec 25 2024
Journal Name
Al–bahith Al–a'alami
Performance and Dialogue Skills of TV news Broadcasters
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Television is one of the best means of transmitting news, as it presents to us the events and facts in our homes in an integrated manner that depends in their formation on the two elements of sound and image, as they relate to the different emotions of each individual as long as he enjoys the blessings of hearing and sight, in addition to that the image is of great importance and is the basis of persuasion for the recipient, which is stronger An influence from the audio or readable word, at a time when the reader of the newsletter (the broadcaster) should have high performance and preventive skills and a distinguished profession in his work, and the only authority that has the right to judge this is the viewer himself. The performance an

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Publication Date
Sun Dec 07 2014
Journal Name
Baghdad Science Journal
Role of TGF-?1 in Urinary Bladder Carcinoma
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The present study aimed to evaluate sera TGF- ?1 concentration in patients with urinary bladder carcinoma (UBC). All malignant of them was transitional cell carcinoma (TCC) type , patients with urinary bladder disorders (UBD ) and healthy control , and to study the correlation between sera TGF-?1 levels and tumor stages and grades in UBC patients . A direct ELISA test was used to quantify the seraTGF-?1 concentrations in sera of 58 patients with urinary bladder carcinoma UBC of different grades (G) and stages (T) all malignant of them was transitional cell carcinoma (TCC) type , 15 from patients with UBD and 15 healthy subjects . Sera levels of TGF-?1 were elevated in patients with UBC and UBD compared to healthy (P ? 0

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Publication Date
Mon Jul 01 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Case Report and Review of Articles: Rheumatoid Vasculitis
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We describe here a case of a 70 yr old man with long-standing rheumatoid arthritis who presented with low grade fever, fatigue, loss of appetite and weight, bluish discoloration of the fingers and patches of gangrenous skin on the fingers. There was intense pain in the fingers which prevented him from sleep. Along with these symptoms he developed loss of sensation in the dorsum of left foot, then left foot drop. We give below full account of the case and review of the causes of vasculitis. We want to emphasize on the importance of identifying vasculitis as one of the complications of rheumatoid arthritis and intensive treatment of this complication, as it is a life-threatening complication.

 

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Publication Date
Tue Jan 04 2022
Journal Name
Iraqi Journal Of Science
Evaluation of Baghdad water quality using Fuzzy logic
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Fuzzy measures are considered important tools to solve many environmental problems. Water pollution is one of the environmental problems, which has negatively effect on the health of consumers. In this paper, a mathematical model is proposed to evaluate water quality in the distribution networks of Baghdad city. Fuzzy logic and fuzzy measures have been applied to evaluate water quality with respect to chemical and microbiological contaminants. Our results are evaluate water pollution of some chemical and microbiological contaminants, which are difficult to evaluation through traditional methods.

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Publication Date
Thu Jan 27 2022
Journal Name
Iraqi Journal Of Science
Solvothermal Synthesis and Characterization of Indium Oxid Nanoparticles
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In this study, In2O3 was prepared by Solvothermal technique in autoclave device, which is a simple and inexpensive technique to indicate the best condition. The reaction took place between indium chloride and urea. In(OH)3 as-prepared annealing at 100°C and convert to In2O3 at annealing temperatures 300, 500, 700 °C for 90 min .The physical properties of nanoparticles were characterized by XRD, SEM, AFM, UV/Visible and FTIR spectroscopy measurements. The examination results of XRD for In2O3 powder annealed at different temperature showed the formation of a cubic phase of nanoparticles with high intensity of plane (222). The lattice constant decreases with the increase of annealing temperature (from 10.07 to 10.04 Ǻ). AFM indicated an

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Publication Date
Sun Mar 19 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Swelling Behavior of Cross-link PVA with Glutaraldehyde
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             The polymeric hydrogels composed of poly vinyl alcohol (m.wt 72000) and glutaraldehyde(5%,8% and 10%) , have been thermally prepared for the purpose of studying their swelling and drug  release behavior .      The swelling ratio was measured for all the hydrogel samples at 37°C, in three different media pH (1.2, 4.7 and 6.8) as a function of time. The results show  that the maximum swelling ratios were arranged as follows :pH =6.8 >  pH =4.7 > pH =1.2 hydrogels cross linked PVA showed a typical pH  responsive behavior such as high pH has maximum swelling while low  pH  shows minimum swelling.

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Publication Date
Wed Jun 01 2011
Journal Name
Journal Of Economics And Administrative Sciences
Cost of human resources from a behavioral perspective
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Purpose/objective:

1 - To explain the financial impact of the activities and areas of human resources management and the adoption of the methodology for estimating costs on the basis of conduct and statement of how to assess costs and benefits of human resource activities.

2 - Measuring  human capital, and its impact on the financial statements.

 

Design/methodology/approach:

 Concentrated dimensions of the research paper's lack of financial statements prepared by the organizations for information mandated human resource its components of the three (attraction - development

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Publication Date
Fri Jul 21 2023
Journal Name
Journal Of Engineering
Development A Method For Production Of Carbon Nanotubes
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In this work chemical vapor deposition method (CVD) for the production of carbon nanotubes (CNTs) have been improved by the addition of S. Steel mesh container (SSMC) inside which the catalyst (Fe/Al2O3) was placed. Scanning electron microscopy (SEM) investigation method used to study nanotubes produced, showed that high yield of two types of (CNTs) obtained, single wall carbon nanotube (SWCNTs) with diameter and length of less than 50nm and several micrometers respectively and nanocoil tubes with a diameter and length of less than 100nm and several micrometers respectively. The chemical analysis of (CNTs) reveals that the main component is carbon (94%) and a little amount of Al (0.32%), Fe (2.22%) the reminder is oxygen. It was also fou

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Publication Date
Thu Mar 01 2018
Journal Name
Journal Of Engineering
Risks of Design Stage in Iraqi Construction Project
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The management of construction projects needs to complete the basics of system management and work. Starting from the idea and how to turn it into a full study and ended at the construction project completion arriving at the purpose prepared for it, so the projects need to control on its operation and integration system in order to succeed.

It is no secret for who concerned in construction projects field that the design stage is a very important stage in construction project because it determines the final features of the project through the requirements provided by the employer for the consultant to formulate it during this phase in the form of plans, drawings, and specifications, then translated on the ground as the shape of co

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Publication Date
Thu May 28 2020
Journal Name
Iraqi Journal Of Science
Human Action Recognition Based on Bag-of-Words
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Human action recognition has gained popularity because of its wide applicability, such as in patient monitoring systems, surveillance systems, and a wide diversity of systems that contain interactions between people and electrical devices, including human computer interfaces. The proposed method includes sequential stages of object segmentation, feature extraction, action detection and then action recognition. Effective results of human actions using different features of unconstrained videos was a challenging task due to camera motion, cluttered background, occlusions, complexity of human movements, and variety of same actions performed by distinct subjects. Thus, the proposed method overcomes such problems by using the fusion of featur

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