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Formulation and Evaluation of Bilayer Tablets Containing Immediate Release Aspirin Layer and Floating Clopidogrel Layer
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Aspirin and clopidogrel are considered the most important oral platelets aggregation inhibitors. So it is widely used for treatment and prophylaxis of cardiovascular and peripheral vascular diseases related to platelets aggregation .In this study aspirin and clopidogrel were formulated together as floating bilayer tablet system. Three different formulas of 75 mg aspirin were prepared by wet granulation method as immediate release layer; different disintegrants used to achieve rapid disintegration. Formula with crosscarmellose as disintegrant achieve rapid disintegration was selected for preparation of bilayer tablet.

Different formulas of 75 mg clopidogrel were prepared as sustained release floating layer by wet granulation (effervescent ) method ;the physical and floating properties for compressed clopidogrel matrix were studied in addition to study the effect of polymer  concentration(HPMC) ,and its combination with ethyl cellulose and carbapol ,effect of different diluents and effect of increasing sodium bicarbonate amount on the release from compressed matrix .

Formula prepared with HPMC and EC in a ratio of 1:1 was capable to retard the release of clopidogrel for 6 hours in addition to its good floating behavior and therefore selected to prepare bilayer tablets in combination with selected aspirin layer.

The prepared bilayer tablets were further subjected to evaluation of their physical, floating properties and release behavior. Finally the kinetic study reflects acceptable shelf life for aspirin and clopidogrel.

Key words: Aspirin, Clopidogrel, Bilayer tablet, Floating tablet.

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Publication Date
Fri Dec 01 2023
Journal Name
International Society For The Study Of Vernacular Settlements
Evaluation of Sustainability Using LEED Rating Scales: The Bismayah New City in Baghdad, Iraq
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Publication Date
Sat Feb 01 2014
Journal Name
Journal Of Economics And Administrative Sciences
Evaluation The Performance efficiency of the general company for lather Industries (a practical study)
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The performa of evaluation process is a process that should be carried out by all industrial management in order to stand on aspects of development or underdevelopment of the various departments and activities in its industrial project for the purpose of identifying obstacles and find out the causes and then avoid them quickly. And intended to rectify the performance evaluation of the  activities of  industrial project  or economic union by measuring the results achieved within a specific operational process and compare it to what is already targeted, and often the time for comparison of one year.

The process of performance evaluation depends upon several criteria and indicators within the

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Publication Date
Wed Feb 22 2023
Journal Name
Iraqi Journal Of Science
Evaluation the Biosorption Capacity of Water Hyacinth (Eichhornia crassipes) Root for Some Heavy Metals
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Heavy metals especially lead (Pb), cadmium (Cd), chromium (Cr) and copper (Cu) are noxious pollutants with immense health hazards on living organisms, these pollutants enter aquatic environment in Iraq mainly Tigris and Euphrates rivers via waste water came from different anthropological activities, This study investigated capacity of dried and ground root of water hyacinth (Eichhornia crassipes) in removing the heavy metals from their aqueous solutions. Effects of initial concentrations of the heavy metals and pH of their aqueous solutions were studied. Results of this study revealed excellent biosorption capacity of water hyacinth root in general, removal of Pb was the highest and Cr was lowest. The results showed that the Pb, Cu and C

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Publication Date
Fri Nov 01 2019
Journal Name
Sylwan Journal
Immunohistochemical evaluation for osteonectin on healing process of intrabony defect treated by Panax ginseng
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Background: The repair of bone defects remains a major clinical orthopaedic challenge. Bone is a highly vascularised tissue reliant on the close spatial and temporal connection between blood vessels and bone cells to maintain skeletal integrity. This study aimed to study the efficacy of Panax ginseng as a osteoinducer in tibia of rat and as a stimulator for bone healing and to study the immunohistochemical expression of osteonectin as bone formation markers in experimental and control groups during bone healing. Material and method: : In this study thirty albino male rats , weighting (200-300) gram ,aged (2-3) months ,will be used under control conditions of temperature ,drinking and food consumption. The animals will subject for an

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Publication Date
Sat Mar 26 2022
Journal Name
Neuroquantology
Efficiency Evaluation of Optical System Includes Different Stop Apertures When Using Relative Moving Factor
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In this work, optical system with different aperture shapes (circular, square, elliptical and triangle aperture) has been used for efficiency evaluation when the system involved moving factor in ideal case (aberration free). The optical system evaluate far moving object, therefore the image forming at image plane due to point spread function (image formula of incoherently illuminated point object). A mathematical treatment has been used to getting results by Gaussian numerical calculations method. The results show priority of circular aperture when optical system that submits of moving factor.

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Publication Date
Wed May 01 2019
Journal Name
Iraqi Journal Of Science
Evaluation of Heavy Metal Accumulation in Sawa Lake Sediments, Southern Iraq using Magnetic Study
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Heavy metal contamination comprises a great concern in the environment. A magnetic study combined with heavy metal analyses was performed in the Sawa Lake in Al-Muthanna governorate (southern Iraq). Concentrations of selected heavy metals (Cr, Fe, Ni, As and Pb) have been measured and magnetic susceptibility (χ) of sediment samples collected from the lake bottom was calculated.

The results confirmed that a cement plant, which is located less than two kilometers away from the lake has no contamination levels on the lake’s sediments. No enhancement in the magnetic susceptibility was observed. X-ray florescence (XRF) was performed for heavy metal analyses.

Spatial variations of χ with the mean value of 4.58 x

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Publication Date
Thu Jan 23 2025
Journal Name
Journal Of Baghdad College Of Dentistry
Evaluation of en-masse retraction using microimplant versus conventional techniques: An in vitro study
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Background: The study aimed to investigate the effect of different techniques of en masse retraction on the vertical and sagittal position, axial inclination, rate of space closure, and type of movement of maxillary central incisor. Materials and methods: A typodont simulation system was used (CL II division 2 malocclusion). Three groups were used group 1(N=10, T-loop), group 2(N=10, Time-Saving loop), and group 3(N=10, Microimplant). Photographs were taken before and after retraction and measurements were made using Autodesk AutoCAD© software 2010. Kruskal-Wallis one-way analyses of variance and Mann-Whitney U test (p?0.05) were used. Results: The rate of space closure showed no significant difference among the three groups (p?0.05), whi

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Publication Date
Fri Jul 21 2023
Journal Name
Journal Of Engineering
Quality Evaluation of Al-Rasheed Ready Concrete Mixture Plant By Using Six Sigma Approach
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The objective of this research work is to evaluate the quality of central concrete plant of Al-Rasheed Company by using Six Sigma approach which is a measure of quality that strives for near elimination of defects using the statistical methods to improve outputs that are critical to customers. The fundamental objective of Six Sigma methodology is the implementation of a measurement-based strategy that focuses on process improvement and variation reduction to reach delighting customers, and then suggesting an improvement system to improve the production of concrete in Al-Rasheed State Contracting Construction Company.
A field survey includes two parts (open and close questionnaire) that aimed to get the data and information required f

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Publication Date
Tue Jan 30 2018
Journal Name
Iraqi Journal Of Science
Evaluation of Orbital Maneuvers for Transition from Low Earth Orbit to Geostationary Earth Orbit
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The transition from low Earth orbit 200-1500 (km) to geostationary Earth orbit 42162 (km) was studied in this work by many methods of transfer. The delta-v requirement (Δv), the time of flight (Δt), the mass ratio of propellant consume (Δm/m) and total mass was calculated for many values altitude in the same plane also when the plane is change. The results from work show that (Δv) that required for transfer when the plane of orbit change is large than (Δv) required when the transfer in coplanar maneuvers while the bi-elliptical transfer method need time of transfer longer than a Hohmann transfer method. The most energy efficiency was determined when the transfer in coaxial between elliptical orbits

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Publication Date
Mon Jan 31 2022
Journal Name
Iraqi Journal Of Science
Evaluation of Water Quality for Greater Zab River by Principal Component Analysis/ Factor Analysis
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This study was conducted to determining the variable effects on water quality of Greater Zab River in Erbil province, Iraq, using multivariate statistical analysis. Seventeen variables were monitored in four sampling sites during one year (from May 2012 to April 2013). The dataset were treated using principal component analysis (PCA)/ factor analysis (FA), cluster analysis (CA) to the most important factors affecting water quality, sources of pollution and suitability of water for drinking consumption and irrigation. Six factors were identified as responsible for the data structure explaining 73.5% of the total variance in the dataset and are conditionally named, hydrochemical from weathering, mineral salts and domestic wastes. CA showed

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