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Preparation and Evaluation of Cefixime Nanocrystals
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Drug nanocrystals are nanoscopic crystals of the parent compound with dimensions less than 1 µm. A decrease in particle size will lead to an increase in effective surface area in the diffusion layer, which, in turn, increases the drug dissolution rate. Drug nanocrystals are one of the most important strategies to enhance the oral bioavailability of hydrophobic drugs.

Cefixime is the first member of what is generally termed the third generation orally active cephalosporins. These third generation cephalosporins are distinct from the older β-lactam antibiotics in their intensive antibacterial activity against a wide range of gram-negative bacteria.

The aim of this study is to prepare nanocrystals of cefixime as a capsules dosage form in order to increase its oral dissolution rate and bioavailability.

The cefixime nanocrystals were prepared by solvent/antisolvent precipitation method. Certain amount of drug was dissolved in water miscible solvent (methanol used in this study), then this solution was injected (at certain speed) into water containing stabilizer. Upon injection, precipitation of cefixime nanocrystal will occur immediately; this precipitate is sonicated at 37 ËšC for 30 min. then lyophilized. Powder of nanocrystal was obtained and filled into capsules. The physicochemical interaction between drug and addatives was studied using FTIR, DSC,

Results show that the best formula of cefixime nanocrystals prepared by dissolving 20mg/ml of cefixime in methanol, then 5ml was injected at 60ml/hr rate to a 50ml PVP solution as stabilizer in concentration 0.05%, then lyophilized to obtain the cefixime nanocrystal powder. The resulted mean particle size was 9-11 nm and the dissolution rate was significantly higher than that of the raw cefixime powder (p>0.05).

Keywords:  Cefixime trihydrate, Nanocrystals, Anti-solvent precipitation, PVP, HPMC, Poloxamer 188.

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Publication Date
Sun Mar 08 2026
Journal Name
Journal Of Baghdad College Of Dentistry
Incidence of Cleft Lip and Palate in Al-Ramadi City (Descriptive Epidemiological Study)
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Background Birth defects are one of the causes of pediatric disability and mortality in all around the world. Data on birth defects from population-based studies originating from developing countries are lacking. Cleft lip (CL), cleft lip and palate (CLP), and isolated cleft palate (CP), collectively termed oral clefts, occur in all races, both sexes, and all socioeconomic groups and vary internationally (1). The main aim of this research is to establish the frequency of cleft lip and/or palate in the population of the Al-Ramadi City, and to characterize the demographic features of affected individuals and find possible risk factors. Materials and methods We conducted a survey of the Educational Maternal and Pediatric Hospital in Al-Ramadi

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Publication Date
Sat Mar 30 2024
Journal Name
Journal Of Kufa For Mathematics And Computer
Approximate Solution of Linear and Nonlinear Partial Differential Equations Using Picard’s Iterative Method
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Publication Date
Wed Feb 22 2023
Journal Name
Iraqi Journal Of Agricultural Sciences
RESPONSE SEEDS PRODUCTION OF BROAD BEAN TO FOLIAR SPRAY WITH MAGNESIUM AND BORON
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Publication Date
Fri Sep 26 2025
Journal Name
Pubmedia Jurnal Pendidikan Olahraga
Psychological Expenditure and its Relationship to the Serving Skills of Specialized Volleyball Players
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The importance of this research lies in developing a psychological expenditure scale and its relationship to the passing skills of specialized volleyball players. The research problem focused on psychological expenditure as one of the problems and challenges faced by specialized players and its negative impact, such as poor skill performance, which is reflected in the performance of the player and the team. This weakens the player's self-confidence and concentration and affects the team's performance in tournaments as well as their performance in training. The research aims to develop a psychological expenditure scale, and the researcher used the descriptive approach as it is appropriate for the nature of the research problem. The f

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Publication Date
Thu Dec 06 2018
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Effects of Vitamin E and Q10 Supplementation against Doxorubicin-Induced Neurotoxicity in Rats
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Publication Date
Wed Jul 31 2024
Journal Name
Cureus
Neuro-Ophthalmic Manifestations of Carotid Cavernous Fistulas: A Systematic Review and Meta-Analysis
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Publication Date
Wed Sep 30 2009
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Prediction of Effective Bed Thermal Conductivity and Heat Transfer Coefficient in Fluidized Beds
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Experimental study of heat transfer coefficients in air-liquid-solid fluidized beds were carried out by measuring the heat rate and the overall temperature differences across the heater at different operating conditions. The experiments were carried out in Q.V.F. glass column of 0.22 m inside diameter and 2.25 m height with an axially mounted cylindrical heater of 0.0367 m diameter and 0.5 m height. The fluidizing media were water as a continuous phase and air as a dispersed phase. Low density (Ploymethyl-methacrylate, 3.17 mm size) and high density (Glass beads, 2.31 mm size) particles were used as solid phase. The bed temperature profiles were measured axially and radially in the bed for different positions. Thermocouples were connecte

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Publication Date
Fri Jul 28 2017
Journal Name
Iraqi Journal Of Science
Morphological and Optical Properties of CdS Quantum Dots Synthesized with different pH values
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Publication Date
Fri Dec 01 2023
Journal Name
Advances In Science And Technology Research Journal
Experimental Investigation and Fuzzy Based Prediction of Titanium Alloy Performance During Drilling Process
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Publication Date
Sun Jun 05 2011
Journal Name
Baghdad Science Journal
Synthesis, spectroscopic and biological studies of some metal complexes with orthoamino hydrazo benzene
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Ortho amino hydrazobenzene (L) has been prepared from the reaction of ortho amino phenyl thiol with phenyl hyrazan in mole ratio(1:1). It has been characterized by elemental analysis (C, H, N), IR, UV–Vis. The complexes of the bivalent ions (Co, Ni, Cu, Zn, Pd, Cd, Hg and Pb) and the trivalent (Cr) have been prepared and characterized too. The structural have been established by elemental analysis(C,H,N), IR , UV – Vis spectra , conductivity measurements , atomic absorption and magnetic susceptibility . The complexes showed characteristic behaviour of octahedral geometry around the metal ion and the( N,N) ligand coordinated in bidentate modeexcept with pd showed square planer. ? ,kf , ?max for the complexes were estimated too .

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