Preferred Language
Articles
/
bijps-353
Design, Synthesis and Kinetic Study of Coumarin-Based Mutual Prodrug of 5-Fluorouracil and Dichloroacetic acid
...Show More Authors

On the basis of known coumarin-based prodrug system, a novel coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid was designed, synthesized and evaluated as a promising oral chemotherapeutic agent basing on in vitro stability study in HCl buffer (pH 1.2) and in phosphate buffer (pH 7.4), as well as in vitro release study in human serum. The chemical structure of prodrug was confirmed by analyzing its FTIR, 1H NMR, 13C NMR and MS-ESI spectra. The results of in vitro kinetic study indicated that the prodrug was significantly stable in HCl and in phosphate buffers, and was hydrolyzed in human serum followed pseudo first order kinetics.

Keywords: Coumarin-based prodrug, 5-fluorouracil, Dichloroacetate, kinetics.

Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Sun Jul 02 2023
Journal Name
Iraqi Journal Of Science
Image Segmentation Using Superpixel Based Split and Merge Method
...Show More Authors

A super pixel can be defined as a group of pixels, which have similar characteristics, which can be very helpful for image segmentation. It is generally color based segmentation as well as other features like texture, statistics…etc .There are many algorithms available to segment super pixels like Simple Linear Iterative Clustering (SLIC) super pixels and Density-Based Spatial Clustering of Application with Noise (DBSCAN). SLIC algorithm essentially relay on choosing N random or regular seeds points covering the used image for segmentation. In this paper Split and Merge algorithm was used instead to overcome determination the seed point's location and numbers as well as other used parameters. The overall results were better from the SL

... Show More
View Publication Preview PDF
Publication Date
Sat Oct 01 2011
Journal Name
Journal Of Engineering
AGENT BASED MONITORING FOR INVESTIGATION PROCESS AND MAINTENANCE IMPROVEMENT
...Show More Authors

Agent technology has a widespread usage in most of computerized systems. In this paper agent technology has been applied to monitor wear test for an aluminium silicon alloy which is used in automotive parts and gears of light loads. In addition to wear test monitoring، porosity effect on
wear resistance has been investigated. To get a controlled amount of porosity, the specimens have
been made by powder metallurgy process with various pressures (100, 200 and 600) MPa. The aim of
this investigation is a proactive step to avoid the failure occurrence by the porosity.
A dry wear tests have been achieved by subjecting three reciprocated loads (1000, 1500 and 2000)g
for three periods (10, 45 and 90)min. The weight difference a

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sat Oct 01 2011
Journal Name
Journal Of Engineering
IMPROVED IMAGE COMPRESSION BASED WAVELET TRANSFORM AND THRESHOLD ENTROPY
...Show More Authors

In this paper, a method is proposed to increase the compression ratio for the color images by
dividing the image into non-overlapping blocks and applying different compression ratio for these
blocks depending on the importance information of the block. In the region that contain important
information the compression ratio is reduced to prevent loss of the information, while in the
smoothness region which has not important information, high compression ratio is used .The
proposed method shows better results when compared with classical methods(wavelet and DCT).

View Publication Preview PDF
Crossref
Publication Date
Tue Oct 18 2022
Journal Name
Ieee Access
Plain, Edge, and Texture Detection Based on Orthogonal Moment
...Show More Authors

Image pattern classification is considered a significant step for image and video processing. Although various image pattern algorithms have been proposed so far that achieved adequate classification, achieving higher accuracy while reducing the computation time remains challenging to date. A robust image pattern classification method is essential to obtain the desired accuracy. This method can be accurately classify image blocks into plain, edge, and texture (PET) using an efficient feature extraction mechanism. Moreover, to date, most of the existing studies are focused on evaluating their methods based on specific orthogonal moments, which limits the understanding of their potential application to various Discrete Orthogonal Moments (DOM

... Show More
Scopus (9)
Crossref (8)
Scopus Clarivate Crossref
Publication Date
Tue Dec 01 2009
Journal Name
J. Appl. Sci
Watermarking based Fresnel transform, wavelet transform, and chaotic sequence
...Show More Authors

Scopus (2)
Scopus
Publication Date
Tue Aug 31 2021
Journal Name
Iraqi Journal Of Science
Image Watermarking Based on IWT and Parity Bit Checking
...Show More Authors

     Various document types play an influential role in a lot of our lives activities today; hence preserving their integrity is an important matter. Such documents have various forms, including texts, videos, sounds, and images.  The latter types' authentication will be our concern here in this paper. Images can be handled spatially by doing the proper modification directly on their pixel values or spectrally through conducting some adjustments to some of the addressed coefficients. Due to spectral (frequency) domain flexibility in handling data, the domain coefficients are utilized for the watermark embedding purpose. The integer wavelet transform (IWT), which is a wavelet transform based on the lifting scheme,

... Show More
View Publication Preview PDF
Scopus (1)
Scopus Crossref
Publication Date
Mon Jan 20 2020
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Image Steganography Based on Wavelet Transform and Histogram Modification
...Show More Authors

      Recently, digital communication has become a critical necessity and so the Internet has become the most used medium and most efficient for digital communication. At the same time, data transmitted through the Internet are becoming more vulnerable. Therefore, the issue of maintaining secrecy of data is very important, especially if the data is personal or confidential. Steganography has provided a reliable method for solving such problems. Steganography is an effective technique in secret communication in digital worlds where data sharing and transfer is increasing through the Internet, emails and other ways. The main challenges of steganography methods are the undetectability and the imperceptibility of con

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sun Dec 29 2019
Journal Name
Iraqi Journal Of Science
Genetic Polymorphisms rs643627 in Serotonin Receptor Gene (5-HTR2A) with Schizophrenia
...Show More Authors

Schizophrenia(SCZ) is oneof the most destructive and complicated chronic diseases of the human nervous system. Serotonin receptors have been involved in the pathophysiology of psychiatric disorders including schizophrenia. Fortyschizophrenia subjects (14females and 26 males) with an age range of 23– 57 years were enrolled, in addition to twenty healthy control subjects (10female and 10 male) with an age range of 19-44 years.

This study aimed to evaluate the frequency of one single nucleotide polymorphism (SNP), namelyrs643627 in HTR2Agene,inIraqi patients with schizophrenia in comparison with controls, along with the association between this SNP and the incidence of schizophrenia.

The genetic variantrs6436

... Show More
View Publication Preview PDF
Scopus (3)
Scopus Crossref
Publication Date
Sat Apr 01 2023
Journal Name
Baghdad Science Journal
COVID-19 Diagnosis Using Spectral and Statistical Analysis of Cough Recordings Based on the Combination of SVD and DWT
...Show More Authors

Healthcare professionals routinely use audio signals, generated by the human body, to help diagnose disease or assess its progression. With new technologies, it is now possible to collect human-generated sounds, such as coughing. Audio-based machine learning technologies can be adopted for automatic analysis of collected data. Valuable and rich information can be obtained from the cough signal and extracting effective characteristics from a finite duration time interval that changes as a function of time. This article presents a proposed approach to the detection and diagnosis of COVID-19 through the processing of cough collected from patients suffering from the most common symptoms of this pandemic. The proposed method is based on adopt

... Show More
View Publication Preview PDF
Scopus (1)
Scopus Crossref
Publication Date
Fri Jan 01 2016
Journal Name
Baghdad Science Journal
Synthesis and Characterization of Some New Metals Complexes of [N-(4-Nitrobenzoyl Amino)-Thioxomethyl] Phenylalanine
...Show More Authors

A new ligand [N-(4-nitrobenzoylamino)-thioxomethyl] phenylalanine is synthesized by reaction of 4-nitrobenzoyl isothiocyanate with phenylalanine (1:1). It is characterized by micro elemental analysis (C.H.N.S.), FT-IR, (UV-Vis) and 1H and 13CNMR spectra. Some metals ions complexes of this ligand were prepared and characterized by FT-IR, UV-Visible spectra, conductivity measurements, magnetic susceptibility and atomic absorption. From results obtained, the following formula [M(NBA)2] where M2+ = Mn, Co, Ni, Cu, Zn, Pd, Cd and Hg, the proposed molecular structure for these complexes as tetrahedral geometry, except copper and palladium complexes are have square planer geometry.