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Protective Effects of Citronellol Against Rhabdomyolysis-Induced Acute Kidney Injury in Mice by Inhibiting NF-κB and IL-1β
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Objectives: acute kidney injury (AKI) is a serious pathophysiology side effect of rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene alcohol (3,7-Dimethyl-6-often-1-ol) found in aromatic plant species' essential oils. In this study, we explored the protective effects of Citronellol on glycerol-induced AKI.

Methods: Four groups of eight mice each (n=8) were formed by randomly dividing the animals into the groups, glycerol-induced AKI model group, low-dose CT-treated group (50mg/kg), high-dose CT-treated group (100mg/kg), and control group. The renal functions of mice from all groups were evaluated using serum urea and creatinine. Creatine kinase (CK) level was used to detect rhabdomyolysis. Inflammatory response was determined using Nf-kB and iL-1B levels.

Results: Citronellol in both doses 50&100 mg/kg significantly decreased serum urea, creatinine and CK as Compared to the glycerol group, as well as treatment with citronellol resulted in a lower expression of both NF-κB and IL-1β in the renal tissue, indicating that citronellol may have an anti-inflammatory effect in AKI.

Conclusion: prophylaxis with low and high doses of citronellol improved inflammatory responses and renal function. It's possible that by inhibiting Nf-kB and iL-1B, these positive effects were achieved, inhibiting the development of inflammatory cytokines as a result. These discoveries reveal fresh details regarding a potential treatment option for kidney injury caused by rhabdomyolysis.

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Publication Date
Fri Dec 29 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Efficacy of Some Insect Growth Regulators (IGR) Against Jasmine White Fly Alearoclava Jasimini ( Homoptera: Aleyrodidae) on Citrus Tree
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The efficacy of five insect growth regulators has been tested against white fly larva Alearoclava jasimini on citrus tree orchards. Data from field tl'ia ls con finned that percent mortalities were 43.7, 33.9, 23.7, 20.8 and     12.3  for  Admiral ( I miL)  pyriproxefen, Nomol t  1 5 SC  (!milL) Teflubenzuren , Match 050 EC (  I milL ) Lufenuren , cascade I 0 F.C (

0.9mi/L) flufenoxaron, and Dimiline 10 EC ( I milL)  Difluben- zuron. The result indicated that Admiral and Nomolt have a continuous  effect for one month , so the treatment needs to be repeated for each four weeks. Also, Admiral and Nomolt effect against eggs hatching by 41. 3 % and

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    Publication Date
    Sat Mar 02 2019
    Journal Name
    World Heart Journal
    The Effects of Chronic Cigarette Smoking on the Right Ventricular Functions in Healthy Young Male Subjects: A Speckle Tracking Echocardiographic Study
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    Background: Chronic cigarette smoking is one of the major risk factors for coronary artery disease. However, it has additional cardiac adverse effects independent of coronary atherosclerosis. Patient and Methods: After informed consent and perm- ission from the review board of the hospital, 80 healthy subjects who were classified as smokers or non-smokers were included in the study. They were examined by standard echocardiography protocol which was followed by two-dimensional speckle tracking to assess the functions of the right ventricle. Results: The tricuspid annular plane systolic excursion (TAPSE) was significantly reduced in smokers as compared to non-smokers (P < 0.05). The tricuspid flow peak late diastolic velocity (A wave) was sig

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    Publication Date
    Fri Dec 01 2023
    Journal Name
    Political Sciences Journal
    Exploring the Effects of European Union Conditionality Language on European Mediterranean Human Rights Dialogue
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    Since more than a decade, human rights dialogue in the European Mediterranean Region has been marked by a number of tensions. Although a number of factors contribute to such disputes, the effect of human rights conditionality, which ties EU economic cooperation progression with partner countries human rights advancement, on the dialogue has not been studied. Understanding the aspects, impacts, and effects of conditionality on Euro-Med relations is crucial for furthering dialogue. Yet this variable has been almost entirely neglected in academic and policy research. The research concludes several direct and indirect impacts of conditionality on human rights dialogue using a mixed methodology approach. Direct effects are reflected in the wi

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    Publication Date
    Thu Dec 01 2016
    Journal Name
    Journal Of Engineering
    Experimental Investigation of Natural Convection into a Horizontal Annular Tube with Porous Medium Effects
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    In this work, an experimental investigation has been done for heat transfer by natural-convection through a horizontal concentric annulus with porous media effects. The porous structure in gap spacing consists of a glass balls and replaced by plastic (PVC) balls with different sizes. The outer surface of outer tube is isothermally cooled while the outer surface of inner tube is heated with constant heat flux condition. The inner tube is heated with different supplied electrical power levels. Four different radius ratios of annulus are used. The effects of porous media material, particles size and annulus radius ratio on heat dissipation in terms of average Nusselt number have been analyzed.

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    Publication Date
    Sat Mar 29 2014
    Journal Name
    International Journal Of Academic Research In Progressive Education And Development
    The Effects of Problem-Based Learning on Self-Directed Learning Skills among Physics Undergraduates
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    The aim of this study is to compare the effects of three methods: problem-based learning (PBL), PBL with lecture method, and conventional teaching on self-directed learning skills among physics undergraduates. The actual sample size comprises of 122 students, who were selected randomly from the Physics Department, College of Education in Iraq. In this study, the pre- and post-test were done and the instruments were administered to the students for data collection. The data was analyzed and statistical results rejected null hypothesis of this study. This study revealed that there are no signifigant differences between PBL and PBL with lecture method, thus the PBL without or with lecture method enhances the self-directed learning skills bette

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    Publication Date
    Sun Mar 03 2013
    Journal Name
    Baghdad Science Journal
    Study the effects of bromothymol blue material on the optical properties for polystyrene (PS).
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    Films of pure polystyrene (ps) and doped by bromothymol blue material with percentages(4%) prepared by using casting technique in room temperature , the absorption and transmission spectra has been recorded in the wavelength rang (200-900)nm and calculated refractive index , reflectivity, real and imaginary parts of dielectric constant and extinction coefficient . this study has been done by recording the absorption and transmission spectra by using spectrophotometer .

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    Publication Date
    Thu Nov 08 2018
    Journal Name
    Iraqi National Journal Of Nursing Specialties
    Effects of Hypothermia on Renal Functions for Patients undergo Coronary Artery Bypass Graft Surgery
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    Objective: To determine the effectiveness of hypothermia on renal functions for patients undergoing
    coronary artery bypass graft CABG surgery.
    Methodology: A purposive (non-probability) sample of (50) patients undergoing Isolated coronary artery
    bypass graft surgery consecutively admitted to the surgical ward, and they were followed up in the
    intraoperative, Intensive Care Unit (ICU) and in the postoperative (surgical ward). Post-operative renal function
    test (glumeruler filteration rate (GFR) by using the Crockroft-Gault formula and serum creatinine level) was
    determined first week post operative and post operative renal function was classified on the base of peak of
    the serum creatinine level and decline of glomeru

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    Publication Date
    Tue May 04 2021
    Journal Name
    Journal Of Tribology
    Hardened Edges Effects on Wear Characteristics of Cultivator Sweeps Using Circular Soil Bin Test
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    Abstract<p>Tillage tools are subject to friction and low-stress abrasive wear processes with the potential deterioration of the desired soil quality, loss of mechanical weed efficacy, and downtime for replacing worn tools. Limited experimental methods exist to quantify investigate the effect of wear-resistant coatings on shape parameters of soil-engaging tools. ASTM standard sand/rubber wheel abrasion and pin-on-disk tests are not able to simulate wear characteristics of the complex shape of the tillage tools. Even though the tribology of tillage tools can be realistic from field tests, tillage wear tests under field conditions are expensive and often challenging to generate repeatable engineeri</p> ... Show More
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    Publication Date
    Sun Jan 01 2023
    Journal Name
    International Journal Of Economics And Finance Studies
    THE EFFECTS OF INFORMATION TECHNOLOGY ADOPTION ON THE FINANCIAL REPORTING: MODERATING ROLE OF AUDIT RISK
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    Publication Date
    Tue Aug 31 2021
    Journal Name
    Al-kindy College Medical Journal
    Assessment of the Effects of SARS-Cov-2 Infection on Multiple Organs Using Laboratory Indices
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    Background: Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is still a severe threaft for human health currently, and the researches about it is a focus topic worldwide.

    Aim of the study: In this study, we will collect some laboratory results of the patients with coronavirus disease (COVID-19) to assess the function of liver, heart, kidney and even pancreas. 

    Subjects and Methods: Laboratory results of the patients with COVID-19 are collected. The biochemical indices are classified and used to assess the according function of liver, heart, kidney; meantime, and blood glucose is also observed and taken as an index to roughly evaluate pancreas.

    Results: There were some in

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