Preferred Language
Articles
/
bijps-2494
Protective Effect of Cafestol on Doxorubicin-induced Genotoxicity in Rats
Doxorubicin is an efficient antineoplastic agent that has a broad antitumour spectrum; however, its genotoxic adverse effects on normal cells can be produced through oxidative damage, and this limits its clinical application. Cafestol is a naturally-occurring diterpene in unfiltered coffee with noteworthy antioxidant, antimutagenic and anti-inflammatory activities.

The present study aimed to investigate the possible protective effect of cafestol against doxorubicin-induced chromosomal and DNA damage in rat bone marrow cells. Wistar

Albino rats of both sexes were administered cafestol (5mg/kg body weight once daily for 14 consecutive days) by oral gavage alone or with doxorubicin which was injected as a single dose (90 mg/kg intraperitoneally at day 14) to induce toxicity. The bone marrow was harvested 24 hours after doxorubicin’s injection in all groups for the assessment of structural chromosomal aberration, micronucleus, and comet assays. The result showed that rats in the doxorubicin-only group exhibited a significant decrease (P<0.05) in mitotic index with a significant elevation (P<0.05) in the % DNA in Tail, micronucleus appearance and total structural chromosomal aberrations compared to those of the negative control group; while oral administration of cafestol 14 days prior to doxorubicin, significantly-reduced the % DNA in Tail, micronucleus appearance, and the total number of chromosomal aberrations (P<0.05), and improved the mitotic index compared to rats intraperitoneally-injected with doxorubicin alone.

This study revealed that cafestol has protective effects against the genotoxicity induced by doxorubicin.

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Thu Dec 09 2021
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients

Background Several studies have addressed the prevalence of Toxoplasma gondii (T. gondii), among Parkinson’s disease (PD) patients in different countries, and the potential association between the infection and PD; the results of these studies were conflicting. The study aims to investigate the prevalence of Toxoplasma infection among sample of Iraqi PD patients. Also, to examine the potential association of age, PD duration, gender, smoking habit, zone of residence and family history of PD, with the prevalence of Toxoplasma infection in PD patients.

Patients and Methods Seventy-four PD patients attaining Dr. Saad Al-Witry Neuroscience Hospital in Baghdad/ Ir

... Show More
Scopus (2)
Scopus Crossref
View Publication Preview PDF
Publication Date
Thu Sep 12 2019
Journal Name
Al-kindy College Medical Journal
The Role of Metformin in patients with Primary Hypothyroidism

Background: Insulin resistance is present in 50% or more of patients with primary hypothyroidism. Metformin can decrease TSH levels in these patients by a complex matter, this can be of great help in clinical practice.

Objective: This study was designed to evaluate the effect of metformin in reducing TSH levels in patients with primary hypothyroidism.

Methods: Hundred patients with primary hypothyroidism, 82 females, 18 males were included in this study, everyone was followed up for two months after adding metformin 850 mg twice daily in addition to thyroxin.

Results: 36 patients (36%) have a normal baseline TSH and no change after 2 months, 64 pa

... Show More
Crossref
View Publication Preview PDF
Publication Date
Wed Oct 28 2020
Journal Name
Iraqi Journal Of Science
Hydrogeological System of Injana Formation in Salahaddin Governorate/ Iraq

Injana Formation is the most extended geological formation in Salahaddin Governorate/ Iraq. About 10% of the studied area is covered by the outcrops of the formation as a recharge area. The formation is a subsurface within the unsaturated zone in 5% of the total studied area, while it exists within the saturated zone in about 85%; it is a major confined groundwater aquifer. Therefore, the hydrogeological system of the layers needs to be re-evaluated to describe the successions of aquifers and confining layers and their relation with each other.

The lithology, depths, water table, saturated thickness, hydraulic characteristics of the aquifers, and the lateral and vertical variations of these characteristics were adopted to classif

... Show More
Scopus (1)
Scopus Crossref
View Publication Preview PDF
Publication Date
Sun Jul 03 2011
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Role of Resistin in Patients with Primary Fibromyalgia

Background: Fibromyalgia syndrome (FMS) is a common rheumatologic syndrome with multiple manifestations and associated with many diseases, it characterized by chronic wide
spread muscular pain and tenderness. Resistin is an adipokine discovered in 2001 and considered as a link between obesity and type 2 diabetes by antagonizing and resisting the
action of insulin as it name encompass ;resistin (resist insulin) . It is secreted mainly from adipose tissue in mice and from white blood cells besides the adipose tissue in humans.
Research reviled that resistin has a role in some inflammatory diseases like Rheumatoid Arthritis (RA).
Objective: The objective of this study is to measure Resistin concentration and

... Show More
Crossref
View Publication Preview PDF
Publication Date
Mon Jul 20 2020
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Anatomical features of Fraxinus ornus L. growing in Iraq

Fraxinus ornus L. is considered as a special species that is frequently planted as a decorative tree in most of the country. The cross-sections of the root and stem are circular in shape and in the secondary growth stage, the vascular tissue in the root and stem consists of secondary xylem in radial rows and the type of vessels in the xylem are ring pours wood. Epidermal cells of leaves undulate on the upper and lower side, hairs are uniseriate and unicellular and the stomata appeared in the abaxial surface only is anomocytic type. The vertical-section of blade leaf includes upper epidermis and lower epidermis followed by the palisade layer and spongy layers. The cross-section of petiole horseshoe shape and the vascular bundles are cover

... Show More
Crossref (2)
Crossref
View Publication Preview PDF
Publication Date
Fri Oct 11 2019
Journal Name
Journal Of The College Of Education For Women
The Mythical Reference in the Poetry of Nabil Yassin

The Mythical Reference in the Poetry of Nabil Yassin

View Publication Preview PDF
Publication Date
Wed Jan 10 2024
Journal Name
The American Journal Of Interdisciplinary Innovation And Research
Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
Some Immunologic Evaluations of Toxoplasmosis in Iraqi Aborted Females

Forty-eight aborted women (Iraqi Arab Muslims) at the first trimester with a serological evidence of toxoplasmosis were investigated. Two age- and ethnic-matched control groups were included: 40 aborted women due to accidental events (Control I), and 40 unmarried (virgin) women (Control II). The subjects were evaluated for the following parameters: HLA-class I antigens (A, B and Cw), blood groups, total and differential counts of leukocytes, lymphocyte subpopulations (CD3+, CD4+ and CD20+ cells), phagocytosis of heat-killed yeast (phagocytic index and NBT index), and total serum levels of immunoglobulins (IgA, IgG and IgM) and complement components (C3 and C4). The HLA-A2 and -Cw8 antigens were significantly increased in the patien

... Show More
Crossref
View Publication Preview PDF
Publication Date
Fri Jul 01 2016
Journal Name
Journal Of Engineering
The Role of Informational Environment in Building Smart City

The research addresses smart city concept as it is the latest urban design trends, by the investment of the capabilities of human, and artificial intelligence for the sake of the advancement of the city. The concept of a smart city is described as one of the most important manifestations of the information revolution, with the end of the twentieth, and the beginning of twenty – first century, The research attributes the emergence of the concept to: deficiencies of means, and traditional methods in building and development of cities, as well as The significant increase in the number of city and global metropolises dwellers. So, smart city approach has been adopted, along with innovative principles and methods which cons

... Show More
View Publication Preview PDF
Publication Date
Thu Dec 01 2011
Journal Name
Journal Of Engineering
PERFORMANCE CHARACTERISTICS OF METHANOL-DIESEL BLENDS IN CI ENGINES

Owing to the energy crisis and pollution problems of today, investigations have concentrated on
decreasing fuel consumption and on lowering the concentration of toxic components in combustion
products by using non-petroleum, renewable, sustainable and non-polluting fuels. While conventional energy sources such as natural gas, oil and coal are non-renewable, alcohol can be coupled to renewable and sustainable energy sources.
In this study, the combustion characteristics of diesel fuel and methanol blends were compared.
The tests were performed at steady state conditions in a four-cylinder DI diesel engine at full load at
1500-rpm engine speed. The experimental results showed that diesel methanol blends provided
12.7% inc

... Show More
Crossref
View Publication Preview PDF