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Autophagy or Apoptosis: Anticancer Molecular Mechanism of Epigallocatechin Gallate with Natural Polyphenol Effect on HepG2 Cells Viability
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Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied.  Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptosis in 70% of the treated HepG2 cells. The up-regulation was recorded in two of autophagy inhibitory genes (FOS-1, FOS-2) and apoptosis inducer gene (DDIT3). While the other ten genes expressed down-regulation after treatment. The down regulation was manifested in the genes of mitochondrial autophagy marker proteins (BNIP3, BNIP3L, and NBR1), the autophagy regulator genes (BIRC5, MAPK9), and the gene that implicated in protein biosynthesis and protein modification (ITGB1). The genes that have pro-apoptotic function in cells (CAPNS1, CFLAR, EIF4G, and RB1) were also showed down-regulation after treatment. Conclusion: Thus, the results demonstrated a potential effect of EGCG to induce apoptosis rather than autophagy in the treated HepG2 cells that could play a good target for therapy. 

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Publication Date
Thu Jun 21 2018
Journal Name
Createspace Independent Publishing Platform
Glossary of Biology Terms
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Publication Date
Sun Jan 01 2023
Journal Name
8th Engineering And 2nd International Conference For College Of Engineering – University Of Baghdad: Coec8-2021 Proceedings
Potential powers of urbanism
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Publication Date
Fri May 01 2015
Journal Name
Journal Of Physics: Conference Series
Spectrum of Secondary Submodules
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Publication Date
Sun Jun 30 2013
Journal Name
Al-kindy College Medical Journal
Huge Chondrosarcoma of Shoulder
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Background: Chondrosarcoma is the second most frequent primary malignant tumor of bone. It is considered relatively an uncommon tumor. Generally it is not common for chondrosarcoma to attend huge size; however, one type was described as mesenchymal chondrosarcoma of low grade cartilaginous cells, with female predominance which can grow to exceptionally large size. Case Presentation: We report a case of Chondrosarcoma, in 30 years old woman of 4 years duration, with a huge mass (weighted 16 Kg) and roughly measured 40x30 x20cm, around the right shoulderInvestigations: Repeated MRI of the shoulder and trunk revealed a clear plane of cleavage between the tumor mass and the chest and abdominal walls and absence of invasion of the abdomen. Ul

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Publication Date
Sun Dec 31 2000
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Preparation of Tartaric Acid
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Publication Date
Sun Apr 02 2017
Journal Name
Journal Of Educational And Psychological Researches
Philosophical origins of psychology
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Since the beginning of Philosophical thinking, philosophers had interested in matters that related to psychology. Greek philosophy had sought different psychological cases such as knowledge, thought, sense, and cognition. Plato classified cognitive processes and distinguished between intelligence, emotions, and desires. As Aristotle believed that soul is the essence of human beings that characterize it from other creatures. Regarding the European philosophy, Descartes linked the optics field to psychology that comprises theories about visual perception. Then, john Watson who interested in behaviorism, he believes that the interpretation of behavior will be materialistic. However, the evolutionary view had great effect on psychology that

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Publication Date
Wed Dec 30 2015
Journal Name
College Of Islamic Sciences
Investment of Zakat funds
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Zakat funds may be invested by the owner or his agent, because there is a delay in the investment, and such delay may harm the beneficiaries.
The scholars agreed on the permissibility of investment if it is received from those who are entitled to zakat after it is received, because if zakat reaches their hands, they become wholly owned by them, and therefore they may dispose of it as the disposition of the owners in their property, like all other permissible acts that are permissible according to shariah. What you will see in the folds of the search, God willing).

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Metaphysics of theater performance
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The research explores through its three parts, to search for the unconscious and the collective unconscious in order to identify the per-formative stimuli and motives and their motivation to produce a performance that is consistent with the metaphysics of the myth or the epic and its different characters from other human characters. The paper also explores in its second section a sort of sacred performance energy. Together, along with motivating the mind and engaging the subconscious, comes a metaphysical text and with its characters and epic events.

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Publication Date
Thu Nov 30 2023
Journal Name
المجلة العراقية للبحوث الانسانية والاجتماعية والعلمية
Issues of contemporary jurisprudence
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Islamic jurisprudence is a divine approach capable of confronting all developments that occur in human society and giving appropriate solutions to them. The research discussed opinions related to some contemporary issues according to the rule of no excess or negligence and according to the rules of removing hardship and facilitating in order to reach the appropriate legal ruling for the nature of the situation to which it may be exposed. Man is in paradise, and the research emphasizes the necessity of taking into account the aspect of precaution when deciding on issues, such as the rules of change and the removal of embarrassment

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Publication Date
Wed Apr 01 2009
Journal Name
Iraqi Journal Of Science
HOFFMAN INDEX OF MANIFOLDS
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For a connected topological space M we define the homeomorphism and period noncoincidence indices of M, each of them is topological invariant reflecting the abundance of fixed point free self homeomorphisms and periodic point free self maps defined on M respectively. We give some results for computing each of these indices and we give some examples and some results relating these indices with Hoffman index.