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The Effect of TNF-Alpha Gene Polymorphisms At -376 G/A, -806 C/T, and -1031 T/C on The Likelihood of Becoming a Non-Responder to Etanercept in A Sample of Iraqi Rheumatoid Arthritis Patients
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Tumor necrosis factor-alpha (TNF-α) antagonists’ therapy are expensive and has a non-responsive rate between 30% to 40% in rheumatoid arthritis patients. Genetic variation plays a vital role in the responsiveness to this type of therapy.The aim of this study is to investigate if the presence of genetic polymorphism in the TNF-α gene promoter region at locations -376 G/A (rs1800750), -806 C/T (rs4248158), and -1031 T/C (rs1799964) affects rheumatoid arthritis patient's tendency to be a non-responder to etanercept.

Eighty RA patients on etanercept (ETN) for at least six months were recruited from the Rheumatology Unit at Baghdad Teaching Hospital. Based on The European League Against Rheumatism response (EULAR) criteria, patients were divided into two groups: responders and non-responders. After polymerase chain reaction amplification of their DNA, the amplified DNA was sequenced by Sanger method to determine the polymorphisms at the positions -376G/A, -806 C/T, and -1031T/C.

The results of this study found that equally Phi correlation and binary logistic regression analysis revealed a non-significant association for all genotypes in the three polymorphic sites with the tendency for being non-responder. Moreover, there was no significant difference in TNF-α mean level or the change in disease activity score for 28 joints (DAS28) after six months of etanercept therapy between all genotypes for each polymorphic site.

The present study concludes that there was no correlation between the polymorphisms in the TNF-α promoter region at -376G/A, -806 C/T, and -1031T/C with the tendency for being non-responder to ETN.

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Publication Date
Sun Nov 01 2020
Journal Name
Systematic Reviews In Pharmacy
Systematic Reviews in Pharmacy | open access Journals
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Systematic Reviews in Pharmacy is a monthly Peer-review open access Journal,different scientists involved in Pharmaceutical research and development

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Publication Date
Mon Jul 01 2019
Journal Name
Iop Conference Series: Materials Science And Engineering
Better Hole Cleaning In Highly Deviated Wellbores
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Abstract<p>Many drilling problems (lost circulation, hurdle in running casing, poor cement jobs, high torque and drag and the necessity of re-drilling and, mechanical stuck caused by cutting accumulation in the wellbore) can be avoided by good hole cleaning during drilling operation especially in directional wells.</p><p>In this experimental work, the cutting transport ratio (CTR) in hole inclined (60 degree) from vertical was estimated by using three values of drilling mud viscosities, three annular velocities, two types of cuttings size and two rotation speed of inner pipe (RPM). Note that the rig consisted from PVC outer casing 4 1/2 inch as OD diameter and inner dri</p> ... Show More
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Publication Date
Mon Jan 08 2024
Journal Name
Al-academy
Formal-semantic metaphor in print advertising design
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The research problem lay in the existing of this direct relation between the increasing and the big variety of the goods and the producing companies which mean the increase of the competition and the directing techniques of the commercial advertisings, which become spread everywhere and in an age characterized with the great varieties in the tests and the stances which requires the designers to seek designing accomplishments that are characterized with creativeness , seriousness and unsallity through the designer depending in constructing his / her texts and his/ her visual items on reference forms metaphors to achieve his / her designing purposes.
So the researcher through her primary flying study seek the identifying the manner of

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Aesthetic Values in Contemporary Daqi-zhou Ceramucs
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The current research deals with an analytical study of the ceramic works of one of the most important Japanese cities in the ceramics industry, which is the city (Dachi-Cho), which is characterized by a special and unique style from the rest of the other Japanese cities, as it uses special techniques for its potters and the families to which they belong, such as the technique of grafting and neriage. And printing graphics on ceramic pots. These and other techniques have spread in various countries of Asia and Europe, all the way to America, and transformations and revolutions have begun in these techniques until they have reached the point of absurdity. With all this scientific and technological development, the city (Dachi-Chu) remained

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Publication Date
Mon Jul 01 2013
Journal Name
Political Sciences Journal
Political pluralism in contemporary Islamic political thought
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The paper deals with the position of the Contemporary Islamic political thought concerning the Islamic of pluralism in party system and the role of political parties in the future Islamic state . this paper focuses on the vision of Mr. mohammad hussain Fadlulah to these topics and his opinion in the legitimacy of alliancy with secular political parties The paper , also discussed his opinion concerning the adaptation of political relations between the Islamic political parties under the rules and lows of secular political system in order to have broad positively the public good

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Publication Date
Sat Dec 30 2023
Journal Name
Al-kindy College Medical Journal
Health System in Iraq Post 2003 War
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Background: War represents a major human crisis; it destroys communities and results in ingrained consequences for public health and well-being

Objective: We set this study to shed light on the public health status in Iraq after the successive wars, sanctions, sectarian conflicts, and terrorism, in light of certain health indicators.

Design: The primary source of data for this analysis comes from the Iraqi Ministry of Health, and The World Health Organization disease surveillance.

Results: Most of the morbidity indicators are high, even those that are relatively declining recently, are still higher than those repor

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Publication Date
Fri Jan 01 2021
Journal Name
International Journal Of Agricultural And Statistical Sciences
NONPARAMETRIC ESTIMATION IN DOUBLY GEOMETRIC STOCHASTIC PROCESSES
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A stochastic process {Xk, k = 1, 2, ...} is a doubly geometric stochastic process if there exists the ratio (a > 0) and the positive function (h(k) > 0), so that {α 1 h-k }; k ak X k = 1, 2, ... is a generalization of a geometric stochastic process. This process is stochastically monotone and can be used to model a point process with multiple trends. In this paper, we use nonparametric methods to investigate statistical inference for doubly geometric stochastic processes. A graphical technique for determining whether a process is in agreement with a doubly geometric stochastic process is proposed. Further, we can estimate the parameters a, b, μ and σ2 of the doubly geometric stochastic process by using the least squares estimate for Xk a

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Publication Date
Fri Jul 01 2016
Journal Name
Journal Of Economics And Administrative Sciences
Reflections informational monitoring in Creative marketing systems
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Abstract:                                                                                                      

         The research aims to measure the impact of infor

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Publication Date
Sun Mar 01 2015
Journal Name
Craniomaxillofacial Trauma & Reconstruction
Mandibular Fractures in Iraq: An Epidemiological Study
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The purpose of this study was to evaluate the epidemiological characteristics of the mandibular fractures relating to gender, age, the etiology of injury, and the rendered treatment modalities and complications. The data of the patients who sustained mandibular fractures were retrieved and were analyzed retrospectively, and based on these data a descriptive analysis was conducted. A total of 112 patients were included in this study; the most common cause was road traffic accidents (RTAs) followed by assaults and missile injuries. The most frequently involved age group was 11 to 20 years, treatment modalities included conservative, closed reduction and indirect fixation, and open reduction and internal fixation (ORIF) in 11.6, 79.5, and 8.9%

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Publication Date
Sun Jun 01 2014
Journal Name
Baghdad Science Journal
Oogenesis in Shabout Barbus grypus Heckel , 1843
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The female Shabout were collected as samples from Dijla river in Baghdad. The oocyte developmental stages were divided in to nine stages, based on nucleus structure , cellular inclusions and ovarian follicle structure ,they are:-( Oogonia stage , Early Perinucleolar Stage , Advanced Perinucleolar Stage , Cortical Alveoli Stage , Primary Yolk Stage , Secondary Yolk Stage , Tertiary Yolk Stage , Migratory Nucleus Stage , Hydration Stage(

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