Liquisolid compact is the most promising technique for increasing dissolution rate and bioavailability of poorly soluble drugs.Clopidogrel bisulfate is an oral antiplatelets used for treatment and prophylaxis of cardiovacular and peripheral vascular diseases related to platelets aggreagation.Clopidogrel has low solubility at high pH media of intestine and low bioavailability of a bout 50% after oral doses.The purpose of this work was to enhance dissolution pattern of clopidogrel through its formulation into liquisolid tablets.A mathematical model was used to calculate the optimum quantities of tween 80 , carrier (Avicel PH 102) and coating material (Aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures.The liq

Recently, dental implants have experienced increasing demand as one of the most effective, permanent and stable ways for replacing missing teeth. However, peri-implant diseases that are multispecies plaque-based infections may ultimately lead to implant failure (i.e., late peri-implantitis). Therefore, the present study aims to detect the microbial diversity of subgingival plaque in peri-implantitis cases (N = 30) by comparing with healthy implants (N = 34) using culture-based identification methods, including VITEK 2 system. An increase in microbial diversity (29 species along with 1 and 7 isolates, which were classified as a genus and unidentified species, respectively) were observed in subgingival sites of diseased implants dominated by

       In terms of the core nucleus plus valence nucleon, shell-model calculations using two model spaces and interactions, the relationship between a nucleus' proton skin, and the difference in proton radii of mirror pairs of nuclei with the same mass number are investigated. In this work, two pairs of mirror nuclei will be studied: 17Ne-17N and 23Al-23Ne. For 17Ne-17N nuclei, p-shell and mixing of psd orbits are adopted with Cohen-Kurath (ckii) and psdsu3 interactions. While for 23Al-23Ne, the sd-shell and sdpf shell are adopted with the universal shell model (USD) and sdpfwa interactions. Also, the ground state density distributions, elastic form factors, and root mean square radii of these pairs' nuclei are studied and com

The concept of entransy dissipation was determined for new type of heat exchanger (shell and double concentric tubes heat exchanger). Three parameters, hot oil flow rate, temperature of inlet hot oil and pressure drop of system were investigated with this concept (entransy dissipation). The results showed that the value of entransy dissipation of oil and of system which represents the summation of entransy dissipation of both oil and water increased with increasing the flow rate of hot oil and these values were larger when cold water flow rate was doubled. Also they were increased with increasing the hot oil inlet temperature at a certain flow rate of hot oil. Furthermore, the pressure drops for hot oil in both shell side and inner tubes

Taliban has returned to the forefront since regaining control of Afghanistan in mid-August 2021, prompting the international community and researchers to speculate whether it has adopted a different political vision and ideology from its previous rule (1996-2001). The previous rule presented a distorted version of governance that lacked clear political and ideological foundations, characterized by impulsive and chaotic decisions, and the absence of a comprehensive theoretical and intellectual framework for governance.

Once again, Taliban returned to power on August 15, 2021, and took control of the country. This raised many questions about Taliban's return, the extent of its flexibility and adaptability that allowed the movement t