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G Protein-Coupled Receptors: Undervalued Targets for Cancer Therapy
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Despite the G protein-coupled receptors (GPCRs) being the largest family of signalling proteins at the surface of cells, their potential to be targeted in cancer therapy is still under-utilised. This review highlights the contribution of these receptors to the process of oncogenesis and points to some likely challenges that might be encountered in targeting them. GPCR-signalling pathways are often complex and can be tissue-specific. Cancer cells hijack these communication networks to their proliferative advantage. The role of selected GPCRs in the different hallmarks of cancer is examined to highlight the complexity of targeting these receptors for therapeutic benefit. Our increasing knowledge of the mechanisms governing the molecular functions of GPCRs may help to identify new targets to treat specific types of cancers.

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Publication Date
Thu Dec 01 2011
Journal Name
Iraqi Journal Of Physics
Multilayer Perceptron for analyzing satellite data
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Different ANN architectures of MLP have been trained by BP and used to analyze Landsat TM images. Two different approaches have been applied for training: an ordinary approach (for one hidden layer M-H1-L & two hidden layers M-H1-H2-L) and one-against-all strategy (for one hidden layer (M-H1-1)xL, & two hidden layers (M-H1-H2-1)xL). Classification accuracy up to 90% has been achieved using one-against-all strategy with two hidden layers architecture. The performance of one-against-all approach is slightly better than the ordinary approach

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Publication Date
Sat Apr 21 2012
Journal Name
Arabian Journal For Science And Engineering
A Procedure for Analysing Reinforced Embankments
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Publication Date
Sun Mar 01 2020
Journal Name
Iop Conference Series: Materials Science And Engineering
Gliding arc discharge for water treatment
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Abstract<p>The significant shortage of usable water resources necessitated the creation of safe and non-polluting ways to sterilize water and rehabilitate it for use. The aim of the present study was to examine the ability of using a gliding arc discharge to inactivate bacteria in water. Three types of Bacteria satisfactory were used to pollute water which are Escherichia coli (Gram-negative), Staphylococcus aurous (Gram-positive) and salmonella (Gram-negative). A DC power supply 12V at 100 Hz frequency was employed to produce plasma. pH of water is measured gradually during the plasma treatment process. Contaminated water treated by gliding arc discharge at steadying the gas flow rate (1.5 l/mi</p> ... Show More
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Publication Date
Tue Mar 07 2017
Journal Name
Journal Of Pharmacy And Pharmacology
Personalised dosing of medicines for children
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Abstract<sec><title>Objectives

Doses for most drugs are determined from population-level information, resulting in a standard ?one-size-fits-all’ dose range for all individuals. This review explores how doses can be personalised through the use of the individuals’ pharmacokinetic (PK)-pharmacodynamic (PD) profile, its particular application in children, and therapy areas where such approaches have made inroads.

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The Bayesian forecasting approach, based on population PK/PD models that account for variability in exposure and response, is a potent method for personalising drug therapy. Its potential utility is eve

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Publication Date
Fri Jan 01 2016
Journal Name
International Journal Of Chemical Engineering
Microbubble Distillation for Ethanol-Water Separation
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In the current study, a novel approach for separating ethanol-water mixture by microbubble distillation technology was investigated. Traditional distillation processes require large amounts of energy to raise the liquid to its boiling point to effect removal of volatile components. The concept of microbubble distillation by comparison is to heat the gas phase rather than the liquid phase to achieve separation. The removal of ethanol from the thermally sensitive fermentation broths was taken as a case of study. Consequently the results were then compared with those which could be obtained under equilibrium conditions expected in an “ideal” distillation unit. Microbubble distillation has achieved vapour compositions higher than th

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Publication Date
Thu Oct 08 2026
Journal Name
Al–bahith Al–a'alami
Cultural and educational values for children
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Programs directed to children through the media in general and in television in particular are among the main factors that help in forming the cultural and educational values of this important segment of society, and in light of this the study problem was identified in answering a major question: What are the cultural and educational values that Ajyal channel seeks Space planted in children through my program, Iftah Ya Simsim (in its new season) and Friends of Ajyal? , While the objectives of the study were evident in identifying the most prominent cultural and educational values that the Ajyal satellite channel worked to instill in children, and identifying the nature of the techniques used by Ajyal channel in providing the value conten

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Publication Date
Sun Feb 01 2026
Journal Name
Softwarex
A toolbox for real orthogonal polynomials
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Publication Date
Sun Feb 01 2026
Journal Name
Softwarex
A toolbox for real orthogonal polynomials
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Publication Date
Tue Sep 08 2020
Journal Name
Baghdad Science Journal
Convergence Analysis for the Homotopy Perturbation Method for a Linear System of Mixed Volterra-Fredholm Integral Equations
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           In this paper, the homotopy perturbation method (HPM) is presented for treating a linear system of second-kind mixed Volterra-Fredholm integral equations. The method is based on constructing the series whose summation is the solution of the considered system. Convergence of constructed series is discussed and its proof is given; also, the error estimation is obtained. Algorithm is suggested and applied on several examples and the results are computed by using MATLAB (R2015a). To show the accuracy of the results and the effectiveness of the method, the approximate solutions of some examples are compared with the exact solution by computing the absolute errors.

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Publication Date
Mon Nov 07 2016
Journal Name
Abu Dhabi International Petroleum Exhibition & Conference
Developed Material Balance Approach for Estimating Gas Initially in Place and Ultimate Recovery for Tight Gas Reservoirs
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Abstract<p>The gas material balance equation (MBE) has been widely used as a practical as well as a simple tool to estimate gas initially in place (GIIP), and the ultimate recovery (UR) factor of a gas reservoir. The classical form of the gas material balance equation is developed by considering the reservoir as a simple tank model, in which the relationship between the pressure/gas compressibility factor (p/z) and cumulative gas production (Gp) is generally appeared to be linear. This linear plot is usually extrapolated to estimate GIIP at zero pressure, and UR factor for a given abandonment pressure. While this assumption is reasonable to some extent for conventional reservoirs, this may incur</p> ... Show More
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