Preferred Language
Articles
/
bijps-1376
G Protein-Coupled Receptors: Undervalued Targets for Cancer Therapy
...Show More Authors

Despite the G protein-coupled receptors (GPCRs) being the largest family of signalling proteins at the surface of cells, their potential to be targeted in cancer therapy is still under-utilised. This review highlights the contribution of these receptors to the process of oncogenesis and points to some likely challenges that might be encountered in targeting them. GPCR-signalling pathways are often complex and can be tissue-specific. Cancer cells hijack these communication networks to their proliferative advantage. The role of selected GPCRs in the different hallmarks of cancer is examined to highlight the complexity of targeting these receptors for therapeutic benefit. Our increasing knowledge of the mechanisms governing the molecular functions of GPCRs may help to identify new targets to treat specific types of cancers.

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Sun Jul 31 2022
Journal Name
Iraqi Geological Journal
A Review of Historical Studies for Water Saturation Determination Techniques
...Show More Authors

Water saturation is the most significant characteristic for reservoir characterization in order to assess oil reserves; this paper reviewed the concepts and applications of both classic and new approaches to determine water saturation. so, this work guides the reader to realize and distinguish between various strategies to obtain an appropriate water saturation value from electrical logging in both resistivity and dielectric has been studied, and the most well-known models in clean and shaly formation have been demonstrated. The Nuclear Magnetic Resonance in conventional and nonconventional reservoirs has been reviewed and understood as the major feature of this approach to estimate Water Saturation based on T2 distribution. Artific

... Show More
View Publication Preview PDF
Scopus (2)
Scopus Crossref
Publication Date
Fri May 17 2019
Journal Name
Lecture Notes In Networks And Systems
Features Selection for Intrusion Detection System Based on DNA Encoding
...Show More Authors

Intrusion detection systems detect attacks inside computers and networks, where the detection of the attacks must be in fast time and high rate. Various methods proposed achieved high detection rate, this was done either by improving the algorithm or hybridizing with another algorithm. However, they are suffering from the time, especially after the improvement of the algorithm and dealing with large traffic data. On the other hand, past researches have been successfully applied to the DNA sequences detection approaches for intrusion detection system; the achieved detection rate results were very low, on other hand, the processing time was fast. Also, feature selection used to reduce the computation and complexity lead to speed up the system

... Show More
Scopus (3)
Scopus
Publication Date
Sat Jul 01 2017
Journal Name
Energy Procedia
Epoxy/Silicone Rubber Blends for Voltage Insulators and Capacitors Applications
...Show More Authors

View Publication
Scopus (19)
Crossref (11)
Scopus Clarivate Crossref
Publication Date
Sun Jan 01 2023
Journal Name
Computers, Materials & Continua
Hybrid Deep Learning Enabled Load Prediction for Energy Storage Systems
...Show More Authors

View Publication
Scopus (16)
Crossref (13)
Scopus Clarivate Crossref
Publication Date
Fri May 13 2022
Journal Name
Electronics
Fuzzy Luenberger Observer Design for Nonlinear Flexible Joint Robot Manipulator
...Show More Authors

The process of controlling a Flexible Joint Robot Manipulator (FJRM) requires additional sensors for measuring the state variables of flexible joints. Therefore, taking the elasticity into account adds a lot of complexity as all the additional sensors must be taken into account during the control process. This paper proposes a nonlinear observer that controls FJRM, without requiring equipment sensors for measuring the states. The nonlinear state equations are derived in detail for the FJRM where nonlinearity, of order three, is considered. The Takagi–Sugeno Fuzzy Model (T-SFM) technique is applied to linearize the FJRM system. The Luenberger observer is designed to estimate the unmeasured states using error correction. The develop

... Show More
View Publication
Scopus (8)
Crossref (7)
Scopus Clarivate Crossref
Publication Date
Mon Jul 01 2019
Journal Name
2019 International Joint Conference On Neural Networks (ijcnn)
A Fast Feature Extraction Algorithm for Image and Video Processing
...Show More Authors

View Publication
Scopus (38)
Crossref (35)
Scopus Clarivate Crossref
Publication Date
Sat May 01 2021
Journal Name
Journal Of Physics: Conference Series
Equivalence of Some Iterations for Class of Quasi Contractive Mappings
...Show More Authors
Abstract<p>In this article, we recalled different types of iterations as Mann, Ishikawa, Noor, CR-iteration and, Modified SP_iteration of quasi δ-contraction mappings, and we proved that all these iterations equivalent to approximate fixed points of δ-contraction mappings in Banach spaces.</p>
View Publication
Scopus (6)
Crossref (4)
Scopus Crossref
Publication Date
Sat Oct 01 2022
Journal Name
The Egyptian Journal Of Hospital Medicine
Developing Gold-Resveratrol Nanoconjugates for Management of Rheumatoid Arthritis (RA)
...Show More Authors

View Publication
Scopus (2)
Crossref (1)
Scopus Crossref
Publication Date
Sat Aug 27 2022
Journal Name
Egyptian Journal Of Chemistry
Evaluation of Zinc Chelation Ability for Non-Hydroxamic Organic Moieties
...Show More Authors

View Publication
Scopus (6)
Scopus Clarivate Crossref
Publication Date
Fri Jul 12 2024
Journal Name
Aaps Pharmscitech
Nanosuspension-Based Repaglinide Fast-Dissolving Buccal Film for Dissolution Enhancement
...Show More Authors

Drug solubility and dissolution remain a significant challenge in pharmaceutical formulations. This study aimed to formulate and evaluate repanglinide (RPG) nanosuspension-based buccal fast-dissolving films (BDFs) for dissolution enhancement. RPG nanosuspension was prepared by the antisolvent-precipitation method using multiple hydrophilic polymers, including soluplus®, polyvinyl alcohol, polyvinyl pyrrolidine, poloxamers, and hydroxyl propyl methyl cellulose. The nanosuspension was then directly loaded into BDFs using the solvent casting technique. Twelve formulas were prepared with a particle size range of 81.6-1389 nm and PDI 0.002-1 for the different polymers. Nanosuspensions prepared with soluplus showed a favored mean particle size o

... Show More
View Publication
Scopus (2)
Crossref (2)
Scopus Clarivate Crossref