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CYP2D6 Genotype in Relation to Liver Toxicity Due to Tetrabenazine in Iraqi Patients with Hyperkinetic Movement Disorders
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Abstract

The  common types of movement disorders are ; dystonia which is a syndrome  of  repetitive muscle contractions. While , Huntington disease is autosomal dominant progressive neurodegenerative disorder, which is characterized by involuntary movements (“chorea”).

Tetrabenazine therapy has been shown to effectively control this movements compared with placebo.

Design the proper dosing approach for patients treated with tetrabenazine with genotype polymorphisms and their hepatic effect on patients.

A prospective case controlled study was carried on 50 patients whom    divided into 2 groups :first group involved 25 patients who had chorea, and group 2 included  patients with dystonia, whom treated with (tetrabenazine) for three months. In addition to control group involved 25 healthy subjects . Blood samples were collected at the beginning and after three months  to assess  liver function  in relation to genetic polymorphism of CYP 450 2D6 enzyme for both groups and measuring the plasma concentration of tetrabenazine , alpha and beta  dyhdrotetrabenazine.

The results show a significant CYP 450 2D6 enzyme polymorphism. And elevations of liver enzymes in the patient indicate hepatotoxicity of tetrabenazine and its metabolites,

Determination a genotype of the CYP 450 2D6  genes in Iraqi patients, in relation  to the safety and efficacy of tetrabenazine  .

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Publication Date
Sat Apr 01 2023
Journal Name
Full Text Book Of Minar Congress8
REGULARITY VIA PRE- GENERALIZED OPEN SETS
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By use the notions pre-g-closedness and pre-g-openness we have generalized a class of separation axioms in topological spaces. In particular, we presented in this paper new types of regulαrities, which we named ρg­regulαrity and Sρg­regulαrity. Many results and properties of both types have been investigated and have illustrated by examples.

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Publication Date
Mon May 11 2020
Journal Name
Baghdad Science Journal
New Concepts of Fuzzy Local Function: Types of fuzzy local function
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The main idea of this paper is to define other types of a fuzzy local function and study the advantages and differences between them in addition to discussing some definitions of finding new fuzzy topologies. Also in this research, a new type of fuzzy closure has been defined, where the relation between the new type and different types of fuzzy local function has been studied

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Publication Date
Sun Jul 31 2022
Journal Name
Iraqi Journal Of Science
Solving the Created Equations from Power Function Distribution
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      In this paper, a new class of ordinary differential equations is designed for some functions such as probability density function, cumulative distribution function, survival function and hazard function of power function distribution, these functions are used of the class under the study. The benefit of our work is that the equations ,which are generated from some probability distributions, are used to model and find  the  solutions  of problems in our lives, and that the solutions of these equations are a solution to these problems, as the solutions of the equations under the study are the closest and the most reliable to reality. The existence and uniqueness of solutions the obtained equations in the current study are dis

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Publication Date
Fri Nov 24 2023
Journal Name
Iraqi Journal Of Science
كفاءة الهستخمص الزيتي لنبات الدارسين Cinnamomum zeylanicum عمى بعض الجوانب الفسمجية والنسجية في الفئ ا رن الهخهجة بالأكياس الهائية العذرية لمهشوكة الحبيبية Echinococcus granulosus
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هدٌفت الد ا رسة إل هعرفة تأثير الهستخمص الزيتي لىبات الدارسين

Cinnamomum zeylanicum عم بعض الجكاىب الفسمجية كالىس جية في الفئ ا رف الهخهجة بالأكياس العذرية أك الطكر اليرقي لمهشككة
الحبيبية Echinococcus granulosus .كتقيي كفاءة الهستخمص الزيتي لىبات الدارسيف ضد الإصابة
التجريبية بالأكياس الهائية العذرية. استخد 40 فأ ا ر قسهت إل أربع هجاهيع هتساكية .حقىت الفئ ا رف في
الهجكعة الأكل كالثاىية كالثالثة ب 2000 رؤيس أكلي / فأر ،

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Publication Date
Thu Apr 28 2022
Journal Name
Iraqi Journal Of Science
ON SN-SPACES
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The aim of this paper is to introduce and study the concept of SN-spaces via the notation of simply-open sets as well as to investigate their relationship to other topological spaces and give some of its properties.

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Publication Date
Wed Mar 01 2023
Journal Name
Baghdad Science Journal
New Structures of Continuous Functions
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         Continuous functions are novel concepts in topology. Many topologists contributed to the theory of continuous functions in topology. The present authors continued the study on continuous functions by utilizing the concept of gpα-closed sets in topology and introduced the concepts of weakly, subweakly and almost continuous functions. Further, the properties of these functions are established.

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Publication Date
Sun May 26 2019
Journal Name
Iraqi Journal Of Science
Isolation and identification of phosphate solubilizing bacteria and evaluate its effect on of Mung bean (Vigna radita [L.] R.Wilczek) growth
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Sixteen soil samples were collected from wheat, barley and yellow corn rhizosphere in Abu-Ghraib, Aqraqof, Latifieh,Tarmiah, Jadriya and  of Agriculture in Baghdad university/ Baghdad city. The results found nine phosphate solubilizing bacteria (PSB) isolates (Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9), formed clear zones on National Botanical Research Institute's (NBRIP) agar. The solubility index (SI) of PSB isolates ranged from 2.00 to 3.66. Y4 have the highest SI (3.66) followed by Y3 and Y6 (3.33). Phosphate solubilization abilities varying from (20.10-39.00 μg.ml-1), Y4 was the highest (39.00 μg.ml-1) followed by Y3 (37.00μg.ml-1). The results of hydrolytic enzymes production showed that almo

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Publication Date
Fri Dec 30 2022
Journal Name
Iraqi Journal Of Science
Revised Manuscript On New Sandwich Results of Univalent Functions Defined by a Linear Operator
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     In this research paper, we explain the use of  the convexity and the starlikness properties of  a given function  to generate  special properties of differential subordination and superordination functions in the classes of analytic functions that have  the form   in the unit disk. We also show the significant of  these properties to derive sandwich results when the Srivastava- Attiya operator   is used.

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Publication Date
Sun Oct 02 2022
Journal Name
Al-manhaj
Mathematical Statistics - Second Edition
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This Book is the second edition that intended to be textbook studied for undergraduate/ postgraduate course in mathematical statistics. In order to achieve the goals of the book, it is divided into the following chapters. Chapter One introduces events and probability review. Chapter Two devotes to random variables in their two types: discrete and continuous with definitions of probability mass function, probability density function and cumulative distribution function as well. Chapter Three discusses mathematical expectation with its special types such as: moments, moment generating function and other related topics. Chapter Four deals with some special discrete distributions: (Discrete Uniform, Bernoulli, Binomial, Poisson, Geometric, Neg

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Publication Date
Sun Apr 30 2023
Journal Name
Iraqi Journal Of Science
Doubly Type II Censoring of Two Stress-Strength System Reliability Estimation for Generalized Exponential-Poisson Distribution
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 In this paper, a Bayesian analysis is made to estimate the Reliability of two stress-strength model systems. First: the reliability  of a one component strengths X under stress Y. Second, reliability  of one component strength under three stresses. Where X and Y are independent generalized exponential-Poison random variables with parameters (α,λ,θ) and (β,λ,θ) . The analysis is concerned with and based on doubly type II censored samples using gamma prior under four different loss functions, namely   quadratic loss function, weighted loss functions,  linear and non-linear exponential loss function. The estimators are compared by mean squared error criteria due to a simulation study. We also find that the mean square error is

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