Background: Lamotrigine is a second generation Anti-epileptic drug; it is widely used for the treatment of epilepsy and bipolar disorder. Sufficient data is not available concerning its teratogenicity. Aim of the study: The study has been carried out to evaluate the effect of lamotrigine on Rat kidney development. Materials and Methods: The study was conducted on 10 pregnant Albino Rats (Rattus rattus) divided equally into two groups, control and experiment groups. Experiment group received lamotrigne 10mg/kg/day orally using naso-gastric tube from the first day of gestation until the first week after birth, while the control group received distilled water. Newborn kidneys were collected at day 7 postnatal and fixated in bouin’s solution, then embedded in the paraffin wax and left to become hard block. Strip of 5µm thickness was made using rotary microtome and blot on clean slides. The slides pass through staining technique using haematoxyllin-eosin and periodic acid Schiff stains. The slides examined under microscope and the kidneys were examined used scanning electron microscope. Results: Normal and well differentiated glomeruli and renal tubules were seen in the kidneys of the control group while a wide range of defect in the renal cortex and medulla elements were seen in the kidneys of treated group represented by enlargement, shrinkage, atrophy and fusion of glomeruli, damaging of the outer layer of bowman capsule with losing of nuclei, atubular glomeruli, extensive adhesion of glomerular tufts to bowman capsule. Expansion, disappearance and irregular capsular (bowman’s) space, cell death, detachment of cell from the basement membrane, dilatation of renal tubules, tubular atrophy, swelling of tubular cells, damaging of epithelium lining of renal tubules with nuclei losses and hemorrhage. Statistically significant differences have been shown in the diameter of renal corpuscle, glomerular tuft, proximal and distal convoluted tubules (p<0.001). There were no significant differences in the average diameter of Bowman’s space and podocyte between the control and experiment groups. Conclusion and Recommendation: The present study concludes that lamotrigine has teratogenic effects on the development of the rat’s kidney. Further research must be carried out to corroborate these findings and establish their applicability to humans
Renal transplantation is a principal treatment option for end-stage kidney failure. Bone loss and fracture are serious complication of kidney transplantation, associated with morbidity and mortality. The pathogenesis of post transplantation bone loss is multifactorial and complex
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Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's Reno protective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney diseases
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In all applications and specially in real time applications, image processing and compression plays in modern life a very important part in both storage and transmission over internet for example, but finding orthogonal matrices as a filter or transform in different sizes is very complex and importance to using in different applications like image processing and communications systems, at present, new method to find orthogonal matrices as transform filter then used for Mixed Transforms Generated by using a technique so-called Tensor Product based for Data Processing, these techniques are developed and utilized. Our aims at this paper are to evaluate and analyze this new mixed technique in Image Compression using the Discrete Wavelet Transfo
... Show MorePraise be to God, and may blessings and peace be upon our master and Prophet Muhammad and those who follow him, and may God be pleased with him
Taha is my guardian and whoever follows their path until the Day of Judgment. And after... The book (The Treasure in the Ten Recitations), written by Abu Muhammad Abdullah bin Abd al-Wasiti, who died in the year 710 AH, is considered one of the important books in recitations: because it included the universal custom that it contained in the books Al-Taysir by Al-Dani and Al-Irshad by Al-Falanisi, as the first of them was specialized.
Satisfy the second with the ten readings
May God bless my time, through His grace and generosity, to achieve this treasure and to publish it
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Correct grading of apple slices can help ensure quality and improve the marketability of the final product, which can impact the overall development of the apple slice industry post-harvest. The study intends to employ the convolutional neural network (CNN) architectures of ResNet-18 and DenseNet-201 and classical machine learning (ML) classifiers such as Wide Neural Networks (WNN), Naïve Bayes (NB), and two kernels of support vector machines (SVM) to classify apple slices into different hardness classes based on their RGB values. Our research data showed that the DenseNet-201 features classified by the SVM-Cubic kernel had the highest accuracy and lowest standard deviation (SD) among all the methods we tested, at 89.51 % 1.66 %. This
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The study was conducted on twenty dogs from variety breeds to estimate the
incidence of tumor mass and determine the risk factors of survey to cases of a year
in veterinary hospital in Baghdad. The most common clinical signs were, ulceration,
bleeding into lesions in addition to drowsiness, anorexia, fever and the others were
depended tumor's location in dog's body like lameness, lacrimation and bloody
constipation etc.
The results showed 70% of the infected dogs were working with military forces
and 30% of them were pet dogs and we found that the highest percentage of tumor
accrued in dogs aged more than 10 years and the females recorded 60% of infection.
Terrier breed had the highest percentage of infection (
Background : The dermatophytesare taxonomically related fungi causing different skin infections referred to as tineas in man or ringworm in man and animals . Objective:This study was established to investigate theof effect of yellow sap and gel of Aloe vera on skin of the rabbits which infected with T.verrucosum. Methods : Twelveskin biopsy were taken from rabbits for histopathological study to know the the effects of the T.verrucosumand treated with yellow sap and gel. Results : the results of histopathological study of effect of yellow sap and gel of Aloe vera on skin of the rabbits which infected with T.verrucosum showed the concentration of the gel of aloe vera at 75% was more effected to treat the infective area of skin with T.verrucos
... Show MoreThis research deals with the effect of gallium oxide and cerium oxide as dopants on the structural and optical characteristics of tin oxide. Gallium and cerium oxide doped tin oxide was prepared with different doping concentrations (0, 0.03, 0.05 and 0.07) wt. pure and doped tin oxide thin films were prepared by the pulsed laser deposition technique. X-ray diffraction and UV-Visible spectrophotometer were employed to investigate both oxides doping effects. Results showed that all prepared samples have poly-crystalline structure with a preferred plane of crystal growth along (110), where the crystal size grew from 40.3 nm to 64.5 nm and to 43.5 nm for Ga2O3 and CeO2 doped tin oxide thin films, res
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